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Study · Ex vivo tissue · rat · 1994

5 results

Dermorphin-induced hyperexcitability in hippocampal CA3 and CA1 in vitro.

Jones LS, Grooms SY, Salvadori S, Lazarus LH

European journal of pharmacology1 Oct 1994Cited by 8 (Europe PMC)

PMID7828641 (opens in a new tab)DOI10.1016/0014-2999(94)90633-5 (opens in a new tab)PepBankPUB-07828641
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat hippocampal slices, dermorphin markedly enhanced CA3 threshold responses to Schaffer collateral and mossy fiber stimulation.

    In plain wordsIn lab tests, dermorphin increased rat hippocampal CA3 responses to threshold stimulation.

    Peptide
    Dermorphin
    Outcome
    IncreaseCA3 threshold population responses
    Study

    ratn: not reported in source

    Hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50-100 nMAs given in this study (rat).

    Source sentences

    Summary
    Population responses in CA3 to threshold levels of stimulation from both the Schaffer collaterals and mossy fibers were markedly enhanced in the presence of 50-100 nM dermorphin, while CA1 responses to threshold Schaffer collateral stimulation were less effected.
    1 context sentence
    Summary · context
    Dermorphin, a specific mu 1-opioid receptor agonist, has been studied for its effects on the physiology of the rat hippocampal slice.
  2. 02LabEx vivo tissueActivity measurement

    In rat hippocampal slices, dermorphin affected CA1 threshold Schaffer collateral responses less than CA3 responses.

    In plain wordsIn lab tests, dermorphin affected rat hippocampal CA1 threshold responses less than CA3 responses.

    Peptide
    Dermorphin
    Outcome
    Direction not reportedCA1 threshold responses
    Study

    ratn: not reported in source

    Hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    50-100 nMAs given in this study (rat).

    Source sentences

    Summary
    Population responses in CA3 to threshold levels of stimulation from both the Schaffer collaterals and mossy fibers were markedly enhanced in the presence of 50-100 nM dermorphin, while CA1 responses to threshold Schaffer collateral stimulation were less effected.
    1 context sentence
    Summary · context
    Dermorphin, a specific mu 1-opioid receptor agonist, has been studied for its effects on the physiology of the rat hippocampal slice.
  3. 03LabEx vivo tissueActivity measurement

    In rat hippocampal slices, responses above threshold stimulation responded negligibly to dermorphin.

    In plain wordsIn lab tests, rat hippocampal responses above threshold stimulation changed negligibly with dermorphin.

    Peptide
    Dermorphin
    Outcome
    Direction not reportedResponses above threshold stimulation
    Study

    ratn: not reported in source

    Hippocampal slices
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Responses at higher stimulus levels than threshold were negligibly responsive to dermorphin,
    1 context sentence
    Summary · context
    Dermorphin, a specific mu 1-opioid receptor agonist, has been studied for its effects on the physiology of the rat hippocampal slice.
  4. 04LabEx vivo tissueSafety outcome

    In rat hippocampal slices, all responses became epileptiform with dermorphin at 500 nM.

    In plain wordsIn lab tests, all rat hippocampal responses became seizure-like with dermorphin at 500 nM.

    Peptide
    Dermorphin
    Outcome
    IncreaseEpileptiform responses
    Study

    ratn: not reported in source

    Hippocampal slices
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    500 nMAs given in this study (rat).

    Source sentences

    Summary
    Responses at higher stimulus levels than threshold were negligibly responsive to dermorphin, although at 500 nM dermorphin all responses became epileptiform and in some slices spontaneous bursting erupted.
    1 context sentence
    Summary · context
    Dermorphin, a specific mu 1-opioid receptor agonist, has been studied for its effects on the physiology of the rat hippocampal slice.
  5. 05LabEx vivo tissueSafety outcome

    In rat hippocampal slices, dermorphin at 500 nM evoked spontaneous bursting in some slices.

    In plain wordsIn lab tests, dermorphin at 500 nM triggered spontaneous electrical bursts in some rat hippocampal slices.

    Peptide
    Dermorphin
    Outcome
    IncreaseSpontaneous bursting
    Study

    ratn: not reported in source

    Hippocampal slices
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    500 nMAs given in this study (rat).

    Source sentences

    Summary
    Responses at higher stimulus levels than threshold were negligibly responsive to dermorphin, although at 500 nM dermorphin all responses became epileptiform and in some slices spontaneous bursting erupted.
    1 context sentence
    Summary · context
    Dermorphin, a specific mu 1-opioid receptor agonist, has been studied for its effects on the physiology of the rat hippocampal slice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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