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Study · Non-randomized trial · n = 9 · 1994

11 results

The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults.

Weaver JU, Thaventhiran L, Noonan K, Burrin JM, Taylor NF, Norman MR, Monson JP

Clinical endocrinology1 Nov 1994Cited by 80 (Europe PMC)

PMID7828353 (opens in a new tab)DOI10.1111/j.1365-2265.1994.tb01830.x (opens in a new tab)PepBankPUB-07828353
Publisher pagePubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

  1. 01HumanNon-randomized trialMechanism

    In hypopituitary adults on hydrocortisone, GH decreased urinary cortisol metabolites by 21% (P < 0.01), with an increase after washout.

    In plain wordsIn hypopituitary adults on hydrocortisone, urinary cortisol metabolites decreased during GH treatment and increased after treatment stopped.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseUrinary cortisol metabolites at 6 months
    Study

    n = 9

    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Measurements

    Mean decrement
    21%
    cortisol metabolites

    Source sentences

    Summary
    After 6 months of GH, in patients on hydrocortisone (n = 9), there were significant decreases in CoM (mean decrement 21%, P < 0.01), F/E (mean decreased from 1.27 to 1.0, P = 0.04; reference range 0.33-1.29) and 5 alpha/5 beta tetrahydrocortisol (mean decreased from 0.67 to 0.48, P = 0.01) and a sub…
    1 context sentence
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)
  2. 02HumanNon-randomized trialMechanism

    In hypopituitary adults on hydrocortisone, GH reduced F/E from 1.27 to 1.0 (P = 0.04), with an increase after washout.

    In plain wordsIn hypopituitary adults on hydrocortisone, a cortisol metabolite ratio decreased during GH treatment and increased after treatment stopped.

    Peptide
    HGH (somatotropin)
    Outcome
    Decrease11-hydroxy/11-oxo cortisol metabolite ratio
    Study

    n = 9

    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Measurements

    F/E
    1.27 ratio
    before GH
    F/E
    1 ratio
    after GH

    Source sentences

    Summary
    After 6 months of GH, in patients on hydrocortisone (n = 9), there were significant decreases in CoM (mean decrement 21%, P < 0.01), F/E (mean decreased from 1.27 to 1.0, P = 0.04; reference range 0.33-1.29) and 5 alpha/5 beta tetrahydrocortisol (mean decreased from 0.67 to 0.48, P = 0.01) and a sub…
    1 context sentence
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)
  3. 03HumanNon-randomized trialMechanism

    In hypopituitary adults on hydrocortisone, GH reduced the tetrahydrocortisol ratio from 0.67 to 0.48 (P = 0.01), followed by reversal.

    In plain wordsIn hypopituitary adults on hydrocortisone, another cortisol metabolite ratio decreased during GH treatment and increased after treatment stopped.

    Peptide
    HGH (somatotropin)
    Outcome
    Decrease5 alpha/5 beta tetrahydrocortisol ratio
    Study

    n = 9

    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Measurements

    Tetrahydrocortisol ratio
    0.67 ratio
    before GH
    Tetrahydrocortisol ratio
    0.48 ratio
    after GH

    Source sentences

    Summary
    After 6 months of GH, in patients on hydrocortisone (n = 9), there were significant decreases in CoM (mean decrement 21%, P < 0.01), F/E (mean decreased from 1.27 to 1.0, P = 0.04; reference range 0.33-1.29) and 5 alpha/5 beta tetrahydrocortisol (mean decreased from 0.67 to 0.48, P = 0.01) and a sub…
    1 context sentence
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)
  4. 04HumanNon-randomized trialMechanism

    In hypopituitary adults, lymphocyte glucocorticoid sensitivity tended to be lower during GH therapy than after washout (P = 0.052).

    In plain wordsIn hypopituitary adults, cell tests suggested lower steroid sensitivity during GH therapy than after treatment stopped, without statistical significance.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeGlucocorticoid sensitivity during treatment versus washout
    Study

    n = 8

    Comparator
    After GH washout
    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In-vitro studies demonstrated a trend to reduced glucocorticoid sensitivity on GH therapy; the maximum inhibition of phytohaemagglutinin by dexamethasone tended to be less on GH therapy (P = 0.052) and was also lower than in 29 normal volunteers (P < 0.05).
    2 context sentences
    Summary · context
    Glucocorticoid sensitivity was determined in lymphocyte preparations from 8 patients, during GH therapy and after washout, using an in-vitro technique dependent on dexamethasone suppression of phytohaemagglutinin-stimulated thymidine incorporation into DNA.
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)
  5. 05HumanNon-randomized trialMechanism

    In hypopituitary adults on hydrocortisone, cortisol metabolites showed a downward trend during GH therapy (P = 0.09), reversing after washout (P = 0.04).

    In plain wordsIn hypopituitary adults on hydrocortisone, cortisol metabolites tended to decrease during GH therapy and increased after treatment stopped.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeCortisol metabolites at 12 months
    Study

    n = 7

    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Source sentences

    Summary
    During 12 months of GH therapy, patients on hydrocortisone (n = 7) demonstrated a further trend to decrement in CoM (P = 0.09) which reversed after washout (P = 0.04).
    1 context sentence
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)
  6. 06HumanNon-randomized trialMechanism

    In hypopituitary adults not taking hydrocortisone, F/E fell by 25% during GH therapy.

    In plain wordsIn hypopituitary adults without hydrocortisone treatment, a cortisol metabolite ratio fell by 25% during GH therapy.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseF/E without hydrocortisone
    Study

    n = 2

    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    F/E reduction
    25%
    without hydrocortisone

    Source sentences

    Summary
    Patients not on hydrocortisone (n = 2) demonstrated a normal basal F/E falling by 25% on GH therapy but no change in CoM.
    1 context sentence
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)
  7. 07HumanNon-randomized trialMechanism

    In hypopituitary adults not taking hydrocortisone, GH therapy did not change cortisol metabolites.

    In plain wordsIn hypopituitary adults without hydrocortisone treatment, GH therapy did not change cortisol metabolites.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeCortisol metabolites without hydrocortisone
    Study

    n = 2

    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Patients not on hydrocortisone (n = 2) demonstrated a normal basal F/E falling by 25% on GH therapy but no change in CoM.
    1 context sentence
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)
  8. 08HumanNon-randomized trialMechanism

    In hypopituitary adults, urine free cortisol tended to fall during GH therapy and increased significantly after washout (P < 0.02).

    In plain wordsIn hypopituitary adults, urine free cortisol tended to fall during GH therapy and increased after treatment stopped.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseUrine free cortisol
    Study

    n: not reported in source

    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Source sentences

    Summary
    Urine free cortisol tended to fall during GH therapy and increased significantly following washout after 12 months treatment (P < 0.02).
    1 context sentence
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)
  9. 09HumanNon-randomized trialMechanism

    In hypopituitary adults, cortisol binding globulin decreased by 20% during GH treatment (P < 0.05), remaining within the reference range.

    In plain wordsIn hypopituitary adults, a cortisol-binding protein decreased by 20% during GH treatment but remained within its reference range.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseCortisol binding globulin
    Study

    n: not reported in source

    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    Cortisol binding globulin reduction
    20%
    during treatment

    Source sentences

    Summary
    Serum cortisol binding globulin decreased by 20% (P < 0.05) during 12 months GH treatment but remained within the reference range.
    1 context sentence
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)
  10. 10HumanNon-randomized trialMechanism

    In hypopituitary adults, plasma renin did not change significantly during GH therapy.

    In plain wordsIn hypopituitary adults, plasma renin did not change significantly during GH therapy.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changePlasma renin
    Study

    n: not reported in source

    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were no significant changes in plasma renin but there was a small increment in aldosterone in recumbent patients (P = 0.04) during the open phase of GH therapy in the placebo arm.
    1 context sentence
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)
  11. 11HumanNon-randomized trialMechanism

    In hypopituitary adults originally assigned placebo, aldosterone increased slightly during open-phase GH therapy while recumbent (P = 0.04).

    In plain wordsIn hypopituitary adults originally assigned placebo, aldosterone increased slightly during later GH therapy while lying down.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseAldosterone in recumbent patients
    Study

    n: not reported in source

    Outcome group
    Cortisol metabolism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were no significant changes in plasma renin but there was a small increment in aldosterone in recumbent patients (P = 0.04) during the open phase of GH therapy in the placebo arm.
    1 context sentence
    Summary · context
    We studied 19 adult hypopituitary patients (18 adult onset, M:F, 6:13)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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