In bicarbonate-infused rats, oxytocin given with aldosterone increased the Na+ excretion rate, while aldosterone alone reduced it.
In plain wordsIn bicarbonate-infused rats, oxytocin plus aldosterone raised sodium loss in urine, while aldosterone alone lowered it.
- Peptide
- Oxytocin
- Outcome
- IncreaseNa+ excretion rate in bicarbonate-infused rats
- Study
ratn = 8
Inactin-anaesthetized male Sprague-Dawley rats- Comparator
- Aldosterone alone
- Outcome group
- Kidney function · Kidney and urinary
- Studied dose
- 0.04 pmol/min · intravenous · 2 hAs given in this study (rat).
Measurements
- Peak Na+ excretion rate, pretreatment
- 9 mumol/min
- NaHCO3-infused rats
- Peak Na+ excretion rate, treatment
- 13.5 mumol/min
- NaHCO3-infused rats
Source sentences
In bicarbonate-infused rats (n = 8) Na+ excretion rose within 20 min of the start of treatment from a pretreatment peak of 9.0 +/- 0.8 mumol/min to a peak value of 13.5 +/- 0.8 mumol/min in response to combined hormone administration.
3 context sentences(design, population, supporting numbers)
Aldosterone alone significantly (P < 0.01) reduced Na+ excretion from pretreatment peak value of 5.0 +/- 1.0 to 1.5 +/- 0.4 mumol/min in Adx animals (n = 8) and 9.2 +/- 1.2 to 5.2 +/- 1.2 mumol/min in NaHCO3-infused rats (n = 8) by 2 h after the start of administration.
The possibility of an interaction between oxytocin and aldosterone to influence renal Na+ excretion was investigated in Inactin-anaesthetized male Sprague-Dawley rats.
The effects of 2 h intravenous administration of oxytocin (0.04 pmol/min) and/or aldosterone (42 pmol/min) on renal Na+ handling were studied in 0.077 M NaCl-infused adrenalectomized (Adx) rats and groups of intact animals that were infused with 0.077 M NaHCO3.