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Study · Animal study (in vivo) · rat · 1994

10 results

Treatment with IGF-I peptides improves function of the remnant gut following small bowel resection in rats.

Lemmey AB, Ballard FJ, Martin AA, Tomas FM, Howarth GS, Read LC

Growth factors (Chur, Switzerland)1 Jan 1994Cited by 37 (Europe PMC)

PMID7803042 (opens in a new tab)DOI10.3109/08977199409010990 (opens in a new tab)PepBankPUB-07803042
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In growing rats after 70% jejuno-ileal resection, 278 micrograms/day LR3IGF-I significantly attenuated fat malabsorption.

    In plain wordsIn rats with much of the small bowel removed, the LR3 IGF-I analogue reduced fat malabsorption.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseFat malabsorption after 70% resection
    Study

    ratn: not reported in source

    growing rats after 70 or 80% jejuno-ileal resection
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    278 micrograms/day · subcutaneous infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of 278 micrograms/day IGF-I, LR3IGF-I or des(1-3)IGF-I following 70% jejuno-ileal resection significantly attenuated malabsorption of fat and nitrogen.
    1 context sentence
    Summary · context
    The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In growing rats after 70% jejuno-ileal resection, 278 micrograms/day LR3IGF-I significantly attenuated nitrogen malabsorption.

    In plain wordsIn rats with much of the small bowel removed, the LR3 IGF-I analogue reduced nitrogen malabsorption.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseNitrogen malabsorption after 70% resection
    Study

    ratn: not reported in source

    growing rats after 70 or 80% jejuno-ileal resection
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    278 micrograms/day · subcutaneous infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of 278 micrograms/day IGF-I, LR3IGF-I or des(1-3)IGF-I following 70% jejuno-ileal resection significantly attenuated malabsorption of fat and nitrogen.
    1 context sentence
    Summary · context
    The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after 80% jejuno-ileal resection, LR3IGF-I produced a dose-responsive reduction in malabsorption, with responses less substantial than after 70% resection.

    In plain wordsIn rats with most of the small bowel removed, higher doses of the LR3 IGF-I analogue reduced malabsorption more, but the effect was smaller.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseMalabsorption after 80% resection
    Study

    ratn: not reported in source

    growing rats after 70 or 80% jejuno-ileal resection
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    Dose not stated · subcutaneous infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Responses in rats with 80% resection were less substantial, but a dose-responsive reduction in malabsorption was apparent with LR3IGF-I.
    1 context sentence
    Summary · context
    The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats after 80% jejuno-ileal resection, LR3IGF-I increased body weight gain in a dose-dependent manner.

    In plain wordsIn rats with most of the small bowel removed, the LR3 IGF-I analogue increased weight gain, more so at higher doses.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseBody weight gain after 80% resection
    Study

    ratn: not reported in source

    growing rats after 70 or 80% jejuno-ileal resection
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · subcutaneous infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Both IGF-I and LR3IGF-I were shown to increase body weight gain and food conversion efficiency in a dose-dependent manner following 80% jejuno-ileal resection.
    1 context sentence
    Summary · context
    The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats after 80% jejuno-ileal resection, LR3IGF-I increased food conversion efficiency in a dose-dependent manner.

    In plain wordsIn rats with most of the small bowel removed, the LR3 IGF-I analogue improved how well food turned into weight, more so at higher doses.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseFood conversion efficiency after 80% resection
    Study

    ratn: not reported in source

    growing rats after 70 or 80% jejuno-ileal resection
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · subcutaneous infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Both IGF-I and LR3IGF-I were shown to increase body weight gain and food conversion efficiency in a dose-dependent manner following 80% jejuno-ileal resection.
    1 context sentence
    Summary · context
    The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats after jejuno-ileal resection, LR3IGF-I was more potent than IGF-I at stimulating body weight gain and food conversion efficiency.

    In plain wordsIn rats with part of the small bowel removed, the LR3 IGF-I analogue raised weight gain and feed efficiency more than IGF-I did.

    Peptide
    IGF-1 LR3
    Outcome
    IncreasePotency versus IGF-I on body weight gain and food conversion efficiency
    Study

    ratn: not reported in source

    growing rats after 70 or 80% jejuno-ileal resection
    Comparator
    IGF-I
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · subcutaneous infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    LR3IGF-I was more potent than IGF-I at stimulating body weight gain and food conversion efficiency
    1 context sentence
    Summary · context
    The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats after jejuno-ileal resection, the potency advantage of LR3IGF-I over IGF-I on gut absorptive function and small intestinal re-growth was less marked.

    In plain wordsIn rats with part of the small bowel removed, the LR3 IGF-I analogue had a smaller advantage over IGF-I for gut absorption and regrowth.

    Peptide
    IGF-1 LR3
    Outcome
    Not applicablePotency versus IGF-I on gut absorptive function and small intestinal re-growth
    Study

    ratn: not reported in source

    growing rats after 70 or 80% jejuno-ileal resection
    Comparator
    IGF-I
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    Dose not stated · subcutaneous infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    but its potency advantage on gut absorptive function and small intestinal re-growth was less marked.
    1 context sentence
    Summary · context
    The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats after jejuno-ileal resection, des(1‑3)IGF-I significantly attenuated fat malabsorption.

    In plain wordsIn rats after bowel resection, des(1‑3)IGF-I reduced fat malabsorption.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseFat malabsorption
    Study

    ratn: not reported in source

    70% jejuno-ileal resection
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    278 micrograms/day · subcutaneous infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of 278 micrograms/day IGF-I, LR3IGF-I or des(1-3)IGF-I following 70% jejuno-ileal resection significantly attenuated malabsorption of fat and nitrogen.
    1 context sentence
    Summary · context
    The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats after jejuno-ileal resection, des(1‑3)IGF-I significantly attenuated nitrogen malabsorption.

    In plain wordsIn rats after bowel resection, des(1‑3)IGF-I reduced nitrogen malabsorption.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseNitrogen malabsorption
    Study

    ratn: not reported in source

    70% jejuno-ileal resection
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    278 micrograms/day · subcutaneous infusion · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of 278 micrograms/day IGF-I, LR3IGF-I or des(1-3)IGF-I following 70% jejuno-ileal resection significantly attenuated malabsorption of fat and nitrogen.
    1 context sentence
    Summary · context
    The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins.

Studies that did not test the peptide alone1

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

  1. 10AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome

    In rats after jejuno-ileal resection, treatment with IGF-I peptides increased total gut weight by up to 21%, mainly in the stomach and proximal small bowel.

    In plain wordsIn rats with part of the small bowel removed, IGF-I peptide treatment increased total gut weight, mostly in the stomach and upper small bowel.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseTotal gut weight
    Study

    ratn: not reported in source

    growing rats after 70 or 80% jejuno-ileal resection
    Outcome group
    Intestinal growth and absorption · Gastrointestinal

    Measurements

    total gut weight increase
    ≤ 21%
    IGF-I peptides

    Source sentences

    Summary
    Total gut weight was increased by up to 21%, due predominantly to increased weight of the stomach and proximal small bowel, with the latter effect attributable at least in part to an increased bowel length.
    1 context sentence
    Summary · context
    The effects of 7 days' s.c. infusion of 111-700 micrograms/day IGF-I on gut growth and absorptive function were examined in growing rats following removal of 70 or 80% of the jejuno-ileum, and compared with the responses to the analogues, LR3IGF-I and des(1-3)IGF-I, which bind poorly to IGF binding proteins.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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