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Study · Not a test of the peptide alone · 1995

3 results

Effect of the level of oestradiol on oxytocin-induced prostaglandin F2 alpha release in the cow.

Mann GE, Lamming GE

The Journal of endocrinology1 Apr 1995Cited by 13 (Europe PMC)

PMID7798024 (opens in a new tab)DOI10.1677/joe.0.1450175 (opens in a new tab)PepBankPUB-07798024
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In ovariectomised cows with normal oestradiol, an intravenous oxytocin challenge on days 12 to 16 raised plasma PGFM, a marker of PGF2 alpha release.

    In plain wordsIn cows with normal oestradiol, an oxytocin challenge raised blood levels of a marker of prostaglandin release.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma PGFM rise after oxytocin in the normal oestradiol group
    Study

    cown = 4

    steroid-treated ovariectomised cow
    Comparator
    Pre-injection concentrations
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In the normal group significant rises in plasma PGFM were seen following oxytocin on days 12, 13 and 14 (P < 0.05) as well as days 15 and 16 (P < 0.01).
    2 context sentences
    Summary · context
    Basal and oxytocin-stimulated PGF2 alpha secretion was monitored by measuring concentrations of the principal metabolite of PGF2 alpha, 13,14-dihydro-15-keto PGF2 alpha (PGFM), in plasma samples collected before and after daily i.v. injection of 50 IU oxytocin from days 12-16
    Summary · context
    Long-term ovariectomised cows were pre-treated with progesterone for 14 days followed by oestradiol-17 beta for 2 days to induce oestrus (day 0), and were then treated for a further 16 days with physiological doses of progesterone and oestradiol-17 beta to simulate a luteal phase.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In ovariectomised cows, basal PGFM was unaffected by the level of oestradiol treatment.

    In plain wordsIn cows, the level of oestradiol did not change baseline PGFM, a marker of prostaglandin release.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal PGFM by oestradiol level
    Study

    cown: not reported in source

    steroid-treated ovariectomised cow
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Basal PGFM was unaffected by the level of oestradiol treatment.
    1 context sentence
    Summary · context
    Long-term ovariectomised cows were pre-treated with progesterone for 14 days followed by oestradiol-17 beta for 2 days to induce oestrus (day 0), and were then treated for a further 16 days with physiological doses of progesterone and oestradiol-17 beta to simulate a luteal phase.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In ovariectomised cows, the PGFM rise after an oxytocin challenge was smaller and later in the low oestradiol group than in the normal group.

    In plain wordsIn cows given less oestradiol, the prostaglandin marker rose less after an oxytocin challenge than in cows with normal oestradiol.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-induced PGFM rise in the low oestradiol group versus the normal group
    Study

    cown: not reported in source

    steroid-treated ovariectomised cow
    Comparator
    Normal oestradiol group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In the low group significant elevations in PGFM were only seen on days 15 and 16 (P<0.05), and were smaller (P<0.05) than those seen in the normal group
    1 context sentence
    Summary · context
    Long-term ovariectomised cows were pre-treated with progesterone for 14 days followed by oestradiol-17 beta for 2 days to induce oestrus (day 0), and were then treated for a further 16 days with physiological doses of progesterone and oestradiol-17 beta to simulate a luteal phase.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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