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Study · Not a test of the peptide alone · 1995

3 results

Growth hormone (GH) responses to the combined administration of GH-releasing hormone plus GH-releasing peptide 6 in adults with GH deficiency.

Leal-Cerro A, Garcia E, Astorga R, Casanueva FF, Dieguez C

European journal of endocrinology1 Jun 1995Cited by 32 (Europe PMC)

PMID7788011 (opens in a new tab)DOI10.1530/eje.0.1320712 (opens in a new tab)PepBankPUB-07788011
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    In 13 of 21 adults with long-standing GH deficiency, GHRH plus GHRP‑6 gave a markedly reduced peak GH response.

    In plain wordsIn 13 of 21 adults with growth hormone deficiency, GHRH with GHRP‑6 gave only a small growth hormone peak.

    Peptide
    GHRP-6
    Outcome
    DecreaseProportion with markedly reduced peak GH response to GHRH plus GHRP-6
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Peak GH response
    < 10 mU/l
    13 subjects, GHRH plus GHRP-6

    Source sentences

    Summary
    In 13 subjects GH responses to GHRH plus GHRP-6 were markedly reduced (peak GH response < 10 mU/l)
    2 context sentences
    Summary · context
    In this study, we assessed GH secretion after the combined administration of GH-releasing hormone (GHRH) (1 microgram/kg iv) and GH-releasing peptide 6 (GHRP-6, 1 microgram/kg iv) in adult patients diagnosed with GHD by conventional GH testing, and correlate this response with insulin-like growth factor I levels.
    Summary · context
    Twenty-one subjects (13 male, 8 female) with long-standing diagnosis of GHD aged 21-54 years were studied.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    In 8 of 21 adults with long-standing GH deficiency, GHRH plus GHRP‑6 gave a greater peak GH response.

    In plain wordsIn 8 of 21 adults with growth hormone deficiency, GHRH with GHRP‑6 gave a larger growth hormone peak.

    Peptide
    GHRP-6
    Outcome
    IncreaseProportion with higher peak GH response to GHRH plus GHRP-6
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Peak GH response
    11 to 100 mU/l
    8 subjects, GHRH plus GHRP-6

    Source sentences

    Summary
    whereas in the remaining eight the response was greater (range 11-100 mU/l).
    2 context sentences
    Summary · context
    In this study, we assessed GH secretion after the combined administration of GH-releasing hormone (GHRH) (1 microgram/kg iv) and GH-releasing peptide 6 (GHRP-6, 1 microgram/kg iv) in adult patients diagnosed with GHD by conventional GH testing, and correlate this response with insulin-like growth factor I levels.
    Summary · context
    Twenty-one subjects (13 male, 8 female) with long-standing diagnosis of GHD aged 21-54 years were studied.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome

    In about 40% of adults diagnosed with GH deficiency by conventional testing, GHRH plus GHRP‑6 elicited a significant increase in plasma GH.

    In plain wordsIn about 40% of adults with growth hormone deficiency, GHRH with GHRP‑6 raised growth hormone levels in the blood.

    Peptide
    GHRP-6
    Outcome
    IncreasePlasma GH increase after GHRH plus GHRP-6
    Study

    n = 21

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Patients with significant GH increase
    ≈ 40%
    GHRH plus GHRP-6

    Source sentences

    Summary
    In conclusion, our data show that combined administration of GHRH plus GHRP-6 elicited a significant increase in plasma GH levels in about 40% of patients diagnosed with GHD by conventional GH testing.
    2 context sentences
    Summary · context
    In this study, we assessed GH secretion after the combined administration of GH-releasing hormone (GHRH) (1 microgram/kg iv) and GH-releasing peptide 6 (GHRP-6, 1 microgram/kg iv) in adult patients diagnosed with GHD by conventional GH testing, and correlate this response with insulin-like growth factor I levels.
    Summary · context
    Twenty-one subjects (13 male, 8 female) with long-standing diagnosis of GHD aged 21-54 years were studied.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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