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Study · Animal study (in vivo) · rat · 1995

5 results

[Proteolytic processes in the rat brain and serum in hypokinesia and the adaptive effect of delta-sleep inducing peptide].

Mendzheritskiĭ AM, Lysenko AV, Uskova NI

Biokhimiia (Moscow, Russia)1 Apr 1995

PMID7779981 (opens in a new tab)PepBankPUB-07779981
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, a single DSIP injection caused a long-term alteration of proteolytic enzyme activity over a broad pH range.

    In plain wordsIn rats, one injection of DSIP changed the activity of protein-cutting enzymes for a long time.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedProteolytic enzyme activity after a single injection
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It has been demonstrated for the first time that a single injection of the delta-sleep inducing peptide (DSIP) results in long-term alteration of proteolytic enzyme activity within a broad range of pH.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, DSIP activated limited proteolysis by Ca(2+)-independent neutral endopeptidases of brain synaptosomes and by serum kallikrein.

    In plain wordsIn rats, DSIP increased the limited cutting of proteins by enzymes in brain and blood serum.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLimited proteolysis by neutral endopeptidases and serum kallikrein
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using Ca(2+)-independent neutral endopeptidases from the synaptosomal fraction of rat brain and blood serum kallikrein as an example, it has been shown that DSIP activates limited proteolysis.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, DSIP redistributed activity between Ca(2+)-dependent and Ca(2+)-independent synaptosomal neutral endopeptidases, particularly under hypokinesia.

    In plain wordsIn rats, DSIP shifted activity between two groups of brain enzymes, mainly under hypokinesia (restricted movement).

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedActivity distribution between Ca(2+)-dependent and Ca(2+)-independent neutral endopeptidases under hypokinesia
    Study

    ratn: not reported in source

    hypokinesia
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP also causes the redistribution of activity between Ca(2+)-dependent and Ca(2+)-independent neutral endopeptidases associated with synaptosomal membranes, particularly under hypokinetic conditions.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, DSIP was linked to a significant decrease of Ca(2+)-activated neutral proteinase I activity.

    In plain wordsIn rats, DSIP was linked to a clear fall in the activity of one brain enzyme.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseCa(2+)-activated neutral proteinase I activity
    Study

    ratn: not reported in source

    stress
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The significant decrease of the Ca(2+)-activated neutral proteinase I activity may be one of the mechanisms whereby the modulating effect of DSIP manifested as regulation of the number of glutamate receptors and limitation of effect of this excitatory neuromediator is realized under stress.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, preliminary DSIP injection prevented disturbances in lysosomal membrane permeability during 24 hours of hypokinesia.

    In plain wordsIn rats, DSIP given beforehand prevented changes in cell membrane leakiness caused by 24 hours of restricted movement.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLysosomal membrane permeability disturbance under 24-hour hypokinesia
    Study

    ratn: not reported in source

    hypokinesia
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preliminary injection of DSIP prevents disturbances in the permeability of lysosomal membranes under long-term (24 hours) hypokinesia.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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