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Study · Ex vivo tissue · rat · 1994

6 results

Des (1-3) IGF-I potently enhances differentiated cell growth in olfactory bulb organ culture.

Russo VC, Werther GA

Growth factors (Chur, Switzerland)1 Jan 1994Cited by 21 (Europe PMC)

PMID7779409 (opens in a new tab)DOI10.3109/08977199409011003 (opens in a new tab)PepBankPUB-07779409
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat olfactory bulb cultures, des (1-3) IGF-I was 3-5 fold more potent than IGF-I for amino acid uptake.

    In plain wordsIn lab tests with rat tissue, des (1-3) IGF-I increased amino acid uptake more potently than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseAmino acid uptake potency
    Study

    ratn: not reported in source

    Newborn rat olfactory bulb organ culture
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Relative potency
    3 to 5 fold
    versus IGF-I
    Half maximal response
    20 ng/ml
    des (1-3) IGF-I, about

    Source sentences

    Summary
    Dose dependent responses of 14C amino acid uptake showed des (1-3) IGF-I to be 3-5 fold more potent than IGF-I with a half maximal response at about 20 ng/ml in comparison to 100 ng/ml of IGF-I.
    2 context sentences
    Summary · context
    We proposed in this study to examine the effects of des (1-3) IGF-I on cell function, morphology and on neuronal and glial cell differentiation in our cultured OB model, using cell-specific immunostains for neurons (150 kDa neurofilament) and glial cells (glial fibrillary associated protein--GFAP).
    Summary · context
    OB were cultured in Iscove's serum-free medium containing IGF-I or des (1-3) IGF-I both alone or in combination with bFGF.
  2. 02LabEx vivo tissueActivity measurement

    In rat olfactory bulb cultures, des (1-3) IGF-I supported marked neuronal expression in contrast to IGF-I.

    In plain wordsIn lab tests with rat tissue, des (1-3) IGF-I supported greater neuronal expression than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseNeuronal expression
    Study

    ratn: not reported in source

    Newborn rat olfactory bulb organ culture
    Comparator
    IGF-I 150 ng/ml
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    However, in contrast to IGF-I (150 ng/ml), des (1-3) IGF-I (50 ng/ml) supported marked neuronal expression.
    2 context sentences
    Summary · context
    We proposed in this study to examine the effects of des (1-3) IGF-I on cell function, morphology and on neuronal and glial cell differentiation in our cultured OB model, using cell-specific immunostains for neurons (150 kDa neurofilament) and glial cells (glial fibrillary associated protein--GFAP).
    Summary · context
    OB were cultured in Iscove's serum-free medium containing IGF-I or des (1-3) IGF-I both alone or in combination with bFGF.

Studies that did not test the peptide alone4

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 03LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneEx vivo tissueEfficacy outcome

    In rat olfactory bulb cultures, des (1-3) IGF-I plus bFGF improved morphology compared with IGF-I plus bFGF.

    In plain wordsIn lab tests with rat tissue, des (1-3) IGF-I plus bFGF improved morphology more than IGF-I plus bFGF.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseOrgan morphology with bFGF
    Study

    ratn: not reported in source

    Newborn rat olfactory bulb organ culture
    Comparator
    IGF-I plus bFGF
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    While morphology was close to fresh 6 day OB following culture with IGF-I (150 ng/ml) and bFGF (25 ng/ml), the substitution of des (1-3) IGF-I at 50 ng/ml markedly improved morphology.
    2 context sentences
    Summary · context
    We proposed in this study to examine the effects of des (1-3) IGF-I on cell function, morphology and on neuronal and glial cell differentiation in our cultured OB model, using cell-specific immunostains for neurons (150 kDa neurofilament) and glial cells (glial fibrillary associated protein--GFAP).
    Summary · context
    OB were cultured in Iscove's serum-free medium containing IGF-I or des (1-3) IGF-I both alone or in combination with bFGF.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  2. 04LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneEx vivo tissueActivity measurement

    In rat olfactory bulb cultures, des (1-3) IGF-I plus bFGF produced a neuronal expression pattern close to fresh tissue.

    In plain wordsIn lab tests with rat tissue, des (1-3) IGF-I plus bFGF produced neuronal patterns close to fresh tissue.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Not applicableNeuronal expression pattern with bFGF
    Study

    ratn: not reported in source

    Newborn rat olfactory bulb organ culture
    Comparator
    Fresh olfactory bulb
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Furthermore, when des (1-3) IGF-I (50 ng/ml) was substituted for IGF-I, in combination with bFGF, the pattern of enhanced neuronal expression in the mitral layer was very close to that seen in the fresh 6 day bulb, with dendrites projecting to the glomerular layer.
    2 context sentences
    Summary · context
    We proposed in this study to examine the effects of des (1-3) IGF-I on cell function, morphology and on neuronal and glial cell differentiation in our cultured OB model, using cell-specific immunostains for neurons (150 kDa neurofilament) and glial cells (glial fibrillary associated protein--GFAP).
    Summary · context
    OB were cultured in Iscove's serum-free medium containing IGF-I or des (1-3) IGF-I both alone or in combination with bFGF.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  3. 05LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneEx vivo tissueActivity measurement

    In rat olfactory bulb cultures, widespread poorly organized glial expression occurred with des (1-3) IGF-I alone and other conditions.

    In plain wordsIn lab tests with rat tissue, glial expression was widespread and poorly organized with des (1-3) IGF-I alone.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Not applicableGlial expression with peptide alone
    Study

    ratn: not reported in source

    Newborn rat olfactory bulb organ culture
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In OBs treated with no growth factors, or either IGF-I, des (1-3) IGF-I or bFGF alone, glial expression was widespread and poorly organised, suggesting an injury response.
    2 context sentences
    Summary · context
    We proposed in this study to examine the effects of des (1-3) IGF-I on cell function, morphology and on neuronal and glial cell differentiation in our cultured OB model, using cell-specific immunostains for neurons (150 kDa neurofilament) and glial cells (glial fibrillary associated protein--GFAP).
    Summary · context
    OB were cultured in Iscove's serum-free medium containing IGF-I or des (1-3) IGF-I both alone or in combination with bFGF.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  4. 06LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneEx vivo tissueActivity measurement

    In rat olfactory bulb cultures, des (1-3) IGF-I plus bFGF produced a more ordered enhanced glial response than single-factor conditions.

    In plain wordsIn lab tests with rat tissue, des (1-3) IGF-I plus bFGF produced more organized glial responses than single factors.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseGlial organization with bFGF
    Study

    ratn: not reported in source

    Newborn rat olfactory bulb organ culture
    Comparator
    Single growth factors or no growth factors
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In contrast, following treatment with combinations of bFGF with IGF-I or des (1-3) IGF-I, a more ordered, though enhanced glial response was seen in glomerular and granule cell layers.(ABSTRACT TRUNCATED AT 400 WORDS)
    3 context sentences
    Summary · context
    In OBs treated with no growth factors, or either IGF-I, des (1-3) IGF-I or bFGF alone, glial expression was widespread and poorly organised, suggesting an injury response.
    Summary · context
    We proposed in this study to examine the effects of des (1-3) IGF-I on cell function, morphology and on neuronal and glial cell differentiation in our cultured OB model, using cell-specific immunostains for neurons (150 kDa neurofilament) and glial cells (glial fibrillary associated protein--GFAP).
    Summary · context
    OB were cultured in Iscove's serum-free medium containing IGF-I or des (1-3) IGF-I both alone or in combination with bFGF.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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