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Study · Animal study (in vivo) · rat · 1995

6 results

[Effect of newly developed analogue of growth hormone releasing peptide [D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102)] on growth hormone secretion in adult male rats].

Sawada H

Nihon Ika Daigaku zasshi1 Apr 1995Cited by 4 (Europe PMC)

PMID7775651 (opens in a new tab)DOI10.1272/jnms1923.62.142 (opens in a new tab)PepBankPUB-07775651
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious adult male rats, KP-102 at 0.5 micrograms/kg BW induced a large plasma GH response, which varied with the phase of GH secretion.

    In plain wordsIn rats, KP-102 caused a large rise in growth hormone, depending on the phase of the animals' own GH rhythm.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH response to KP-102 in conscious rats
    Study

    ratn: not reported in source

    Adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.5 micrograms/kg BWAs given in this study (rat).

    Source sentences

    Summary
    KP-102 induced a large plasma GH response at a dose of 0.5 micrograms/kg BW in conscious rats, although GH-releasing abilities of KP-102 varied markedly depending on the phase of GH secretion.
    1 context sentence
    Summary · context
    The effect of a newly developed hexapeptide; D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion was studied in adult male rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In urethan-anesthetized rats, KP-102 alone exerted only a small influence on GH secretion.

    In plain wordsIn anesthetized rats, KP-102 alone had only a small effect on growth hormone release.

    Peptide
    GHRP-2
    Outcome
    Direction not reportedPlasma GH response to KP-102 alone in anesthetized rats
    Study

    ratn: not reported in source

    Adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Among urethan-anesthetized rats, KP-102 alone exerted a small influence on GH secretion
    1 context sentence
    Summary · context
    The effect of a newly developed hexapeptide; D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion was studied in adult male rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In urethan-anesthetized rats given intermittent GRF, somatotropes became refractory to a large GRF bolus, but KP-102 induced a marked increase of plasma GH.

    In plain wordsIn anesthetized rats whose GH cells no longer responded to GRF, KP-102 still caused a marked rise in growth hormone.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH response to KP-102 during intermittent GRF administration
    Study

    ratn: not reported in source

    Adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    During intermittent administration of GRF, the somatotropes became refractory to a large bolus dose of GRF, but KP-102 induced a marked increase of plasma GH.
    1 context sentence
    Summary · context
    The effect of a newly developed hexapeptide; D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion was studied in adult male rats.

Studies that did not test the peptide alone3

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 04AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome

    In urethan-anesthetized rats, KP-102 produced a large plasma GH response in the presence of exogenous GRF.

    In plain wordsIn anesthetized rats, KP-102 given with GRF produced a large growth hormone response.

    Peptide
    GHRP-2
    Outcome
    IncreasePlasma GH response to KP-102 plus GRF
    Study

    ratn: not reported in source

    Adult male rats
    Comparator
    KP-102 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    but it produced a large plasma GH response in the presence of exogenous GH-releasing factor (GRF).
    1 context sentence
    Summary · context
    The effect of a newly developed hexapeptide; D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion was studied in adult male rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 05AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome

    In rats, the GH response to KP-102 alone or with GRF was significantly augmented by prior cysteamine HCl.

    In plain wordsIn rats, cysteamine given beforehand made the growth hormone response to KP-102 larger.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH response to KP-102 after cysteamine pretreatment
    Study

    ratn: not reported in source

    Adult male rats
    Comparator
    No cysteamine pretreatment
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The GH response to KP-102 alone or KP-102 with GRF was significantly augmented when cysteamine HCl was previously administered.
    1 context sentence
    Summary · context
    The effect of a newly developed hexapeptide; D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion was studied in adult male rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  3. 06AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome

    In rats, KP-102 and GRF acted synergistically on GH secretion in control animals and additively in cysteamine-administered rats.

    In plain wordsIn rats, KP-102 and GRF together worked synergistically on growth hormone release in controls, but only additively after cysteamine.

    Peptide
    GHRP-2
    Outcome
    MixedInteraction of KP-102 and GRF on GH secretion in control versus cysteamine rats
    Study

    ratn: not reported in source

    Adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Although KP-102 and GRF acted synergistically on GH secretion in control animals, they acted additively in cysteamine-administered rats.
    1 context sentence
    Summary · context
    The effect of a newly developed hexapeptide; D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion was studied in adult male rats.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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