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Study · In vitro (cells) · 1995

4 results

Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells.

Lei T, Buchfelder M, Fahlbusch R, Adams EF

Journal of molecular endocrinology1 Feb 1995Cited by 38 (Europe PMC)

PMID7772238 (opens in a new tab)DOI10.1677/jme.0.0140135 (opens in a new tab)PepBankPUB-07772238
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human somatotrophinoma cells, GHRP‑6 stimulated PI turnover dose-dependently, with increases in all examined tumours.

    In plain wordsIn cells from human pituitary tumours, GHRP‑6 increased PI turnover as the dose increased.

    Peptide
    GHRP-6
    Outcome
    IncreasePI turnover
    Study

    humann = 8

    Human pituitary somatotrophinoma cell cultures
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    PI turnover increase
    2.1 to 7.9 fold
    8 of 8 tumours

    Source sentences

    Summary
    PI turnover was stimulated by GHRP-6 in 8 of 8 tumours examined, effects ranging from 2.1 - 7.9 fold increases.
    2 context sentences
    Summary · context
    Incubation of somatotrophinoma cells with GHRP-6 led to a dose-dependent stimulation of rate of PI turnover.
    Summary · context
    We have used cell cultures of human pituitary somatotrophinomas to demonstrate powerful effects of GHRP-6 on membrane phosphatidylinositol (PI) turnover, a second messenger system which leads to activation of PKC and mobilisation of intracellular Ca2+ reserves.
  2. 02LabIn vitro (cells)Mechanism

    In human somatotrophinoma cells, GHRP‑6 increased GH secretion in parallel with PI turnover.

    In plain wordsIn cells from human pituitary tumours, GHRP‑6 increased growth hormone release alongside PI turnover.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH secretion
    Study

    humann: not reported in source

    Human pituitary somatotrophinoma cell cultures
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GH secretion was increased in parallel.
    2 context sentences
    Summary · context
    Incubation of somatotrophinoma cells with GHRP-6 led to a dose-dependent stimulation of rate of PI turnover.
    Summary · context
    We have used cell cultures of human pituitary somatotrophinomas to demonstrate powerful effects of GHRP-6 on membrane phosphatidylinositol (PI) turnover, a second messenger system which leads to activation of PKC and mobilisation of intracellular Ca2+ reserves.
  3. 03LabIn vitro (cells)Mechanism

    In human somatotrophinoma cultures, GHRP‑6 effects appeared after 15 minutes and reached a maximum at 2 hours.

    In plain wordsIn cells from human pituitary tumours, GHRP‑6 effects appeared after 15 minutes and peaked at 2 hours.

    Peptide
    GHRP-6
    Outcome
    IncreaseTime course of cellular effects
    Study

    humann: not reported in source

    Human pituitary somatotrophinoma cell cultures
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Effects were discernable after only 15 minutes incubation and rose to a maximum at 2 hours.
    2 context sentences
    Summary · context
    Incubation of somatotrophinoma cells with GHRP-6 led to a dose-dependent stimulation of rate of PI turnover. GH secretion was increased in parallel.
    Summary · context
    We have used cell cultures of human pituitary somatotrophinomas to demonstrate powerful effects of GHRP-6 on membrane phosphatidylinositol (PI) turnover, a second messenger system which leads to activation of PKC and mobilisation of intracellular Ca2+ reserves.
  4. 04LabIn vitro (cells)Mechanism

    In human somatotrophinoma cells, GHRP‑6 stimulation of GH secretion was independent of gsp oncogene presence.

    In plain wordsIn cells from human pituitary tumours, GHRP‑6 stimulated growth hormone release regardless of gsp oncogene presence.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH secretion dependence on gsp oncogenes
    Study

    humann: not reported in source

    Human pituitary somatotrophinoma cell cultures
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Stimulation of GH secretion by GHRP-6 was independent of presence of gsp oncogenes, emphasising the cAMP-independent nature of its effects.
    1 context sentence
    Summary · context
    We have used cell cultures of human pituitary somatotrophinomas to demonstrate powerful effects of GHRP-6 on membrane phosphatidylinositol (PI) turnover, a second messenger system which leads to activation of PKC and mobilisation of intracellular Ca2+ reserves.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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