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Study · Animal study (in vivo) · sheep · 1995

15 results

Metabolic response of sheep skin to a chronic infusion of a variant of insulin-like growth factor I.

Hocking Edwards JE, Khalaf SK, Sinclaire BR, Lee J, Prosser CG, Harris PM

The Biochemical journal1 Jun 1995Cited by 1 (Europe PMC)

PMID7772021 (opens in a new tab)PMCIDPMC1136941 (opens in a new tab)DOI10.1042/bj3080411 (opens in a new tab)PepBankPUB-07772021
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, by day 7 of LR3IGF-I infusion, circulating endogenous IGF-I in plasma was significantly lower than in control sheep.

    In plain wordsIn sheep, the body's own IGF-I in the blood was lower than in control sheep by day 7 of LR3IGF-I infusion.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseCirculating endogenous IGF-I, day 7
    Study

    sheepn = 12

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    By day 7 of the 21-day infusion there was a significant (P < 0.05) decrease in circulating endogenous IGF-I in plasma of treated sheep compared with that of control sheep
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, circulating endogenous IGF-I rose significantly between day 7 and day 21 of LR3IGF-I infusion.

    In plain wordsIn sheep, the body's own IGF-I in the blood rose again between day 7 and day 21 of LR3IGF-I infusion.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseCirculating endogenous IGF-I, day 7 to 21
    Study

    sheepn = 12

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    followed by a significant (P < 0.05) increase between day 7 and 21.
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, plasma insulin levels followed a similar pattern to endogenous IGF-I during LR3IGF-I infusion, lower first and then higher.

    In plain wordsIn sheep, blood insulin followed the same pattern as the body's own IGF-I during LR3IGF-I infusion.

    Peptide
    IGF-1 LR3
    Outcome
    MixedPlasma insulin over 21 days
    Study

    sheepn = 12

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    Plasma insulin levels followed a similar pattern.
    2 context sentences
    Summary · context
    By day 7 of the 21-day infusion there was a significant (P < 0.05) decrease in circulating endogenous IGF-I in plasma of treated sheep compared with that of control sheep, followed by a significant (P < 0.05) increase between day 7 and 21.
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, skin infusion of LR3IGF-I caused an initial (4-24 h) reduction in plasma amino acids, especially tyrosine, valine and lysine.

    In plain wordsIn sheep, LR3IGF-I infused into the skin briefly lowered amino acids in the blood.

    Peptide
    IGF-1 LR3
    Outcome
    DecreasePlasma amino acids at 4-24 h
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    LR3IGF-I caused an initial (4-24 h) reduction in the plasma concentrations of amino acids, especially tyrosine, valine and lysine
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, LR3IGF-I infusion significantly reduced blood oxygen concentration after 24 h.

    In plain wordsIn sheep, LR3IGF-I infused into the skin lowered blood oxygen after 24 hours.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseBlood oxygen after 24 h
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    after 24 h, significant (P < 0.05) reductions in blood oxygen and plasma glucose concentrations.
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, LR3IGF-I infusion significantly reduced plasma glucose concentration after 24 h.

    In plain wordsIn sheep, LR3IGF-I infused into the skin lowered blood glucose after 24 hours.

    Peptide
    IGF-1 LR3
    Outcome
    DecreasePlasma glucose after 24 h
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    after 24 h, significant (P < 0.05) reductions in blood oxygen and plasma glucose concentrations.
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, after 4 h of LR3IGF-I infusion, blood flow through the infused skin increased significantly.

    In plain wordsIn sheep, LR3IGF-I infused into the skin raised blood flow there after 4 hours.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseSkin blood flow after 4 h
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    After 4 h of LR3IGF-I infusion, there was a significant increase in blood flow (P < 0.05) and oxygen uptake (P < 0.05), and net uptake of amino acids [which was significant (P < 0.05) for valine and phenylalanine] by the LR3IGF-I-infused skin was increased.
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, after 4 h of LR3IGF-I infusion, oxygen uptake by the infused skin increased significantly.

    In plain wordsIn sheep, LR3IGF-I infused into the skin raised oxygen use by the skin after 4 hours.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseSkin oxygen uptake after 4 h
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    After 4 h of LR3IGF-I infusion, there was a significant increase in blood flow (P < 0.05) and oxygen uptake (P < 0.05), and net uptake of amino acids [which was significant (P < 0.05) for valine and phenylalanine] by the LR3IGF-I-infused skin was increased.
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, after 4 h of LR3IGF-I infusion, net amino acid uptake by the infused skin increased, significantly for valine and phenylalanine.

    In plain wordsIn sheep, LR3IGF-I infused into the skin raised amino acid uptake by the skin after 4 hours.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseSkin net amino acid uptake after 4 h
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    After 4 h of LR3IGF-I infusion, there was a significant increase in blood flow (P < 0.05) and oxygen uptake (P < 0.05), and net uptake of amino acids [which was significant (P < 0.05) for valine and phenylalanine] by the LR3IGF-I-infused skin was increased.
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, LR3IGF-I infusion significantly increased phenylalanine uptake for skin protein synthesis after 4 and 24 h.

    In plain wordsIn sheep, LR3IGF-I infused into the skin raised the use of phenylalanine for skin protein at 4 and 24 hours.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseSkin phenylalanine uptake for protein synthesis
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    Total uptake of phenylalanine for skin protein synthesis, measured using [3H]phenylalanine uptake, was also significantly increased after 4 and 24 h of infusion.
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, after 48 h of LR3IGF-I infusion, all LR3IGF-I-dependent metabolic measures had fallen to preinfusion values.

    In plain wordsIn sheep, the skin metabolic changes from LR3IGF-I were gone after 48 hours.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeMetabolic measures after 48 h
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Metabolic pathways and metabolomics · Skin and wound
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    After 48 h of infusion all LR3IGF-I-dependent measurements of metabolic parameters had fallen to preinfusion values.
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, after 21 days of LR3IGF-I skin infusion, wool-follicle-bulb-cell mitotic rate did not change.

    In plain wordsIn sheep, 21 days of LR3IGF-I in the skin did not change the division rate of wool follicle cells.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeWool-follicle-bulb-cell mitotic rate
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    After 21 days of infusion there was no effect of LR3IGF-I on wool-follicle-bulb-cell mitotic rate, bulb diameter or wool production.(ABSTRACT TRUNCATED AT 400 WORDS)
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, after 21 days of LR3IGF-I skin infusion, wool follicle bulb diameter did not change.

    In plain wordsIn sheep, 21 days of LR3IGF-I in the skin did not change wool follicle size.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeWool follicle bulb diameter
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    After 21 days of infusion there was no effect of LR3IGF-I on wool-follicle-bulb-cell mitotic rate, bulb diameter or wool production.(ABSTRACT TRUNCATED AT 400 WORDS)
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In sheep, after 21 days of LR3IGF-I skin infusion, wool production did not change.

    In plain wordsIn sheep, 21 days of LR3IGF-I in the skin did not change wool production.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeWool production
    Study

    sheepn = 6

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    After 21 days of infusion there was no effect of LR3IGF-I on wool-follicle-bulb-cell mitotic rate, bulb diameter or wool production.(ABSTRACT TRUNCATED AT 400 WORDS)
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In two LR3IGF-I-infused sheep tested, plasma IGF-binding proteins did not change at any stage of infusion.

    In plain wordsIn two sheep given LR3IGF-I, IGF-binding proteins in the blood did not change.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changePlasma IGF-binding proteins
    Study

    sheepn = 2

    Well-fed castrated Romney sheep, skin arteriovenous preparation
    Comparator
    Saline-infused flank or control sheep
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · continuous skin infusion · 21 daysAs given in this study (sheep).

    Source sentences

    Summary
    There was no change at any stage of infusion in IGF-binding proteins in the plasma of the two LR3IGF-I-infused sheep tested
    1 context sentence
    Summary · context
    A bilateral arteriovenous preparation was used to infuse LR3IGF-I continuously into the skin on one abdominal flank and saline into the other abdominal flank of six sheep; a further six sheep had one flank infused with saline (controls).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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