Total and regional bone mineral content and fracture rate in postmenopausal osteoporosis treated with salmon calcitonin: a prospective study.

Rico H, Revilla M, Hernández ER, Villa LF, Alvarez de Buergo M

Calcified tissue international1 Mar 1995Cited by 44 (Europe PMC)

PMID7750020DOI10.1007/bf00298606PepBankPUB-07750020

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanNon-randomized trialEfficacy outcome
In postmenopausal osteoporotic women, vertebral fracture incidence was 0.07 per patient-year with salmon calcitonin versus 0.45 with calcium alone.
In plain wordsIn postmenopausal osteoporotic women, vertebral fracture incidence was lower with salmon calcitonin than calcium alone.
Peptide
Calcitonin-salmon
Outcome
DecreaseVertebral fracture incidence
Study
n = 72
Comparator
Calcium alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day for 10 days each month · intramuscular · 24 monthsAs given in this study (human).
Measurements
Fracture incidence
0.07 per patient-year
calcitonin
Fracture incidence
0.45 per patient-year
calcium
Source sentences
Summary
The incidence of vertebral fractures was 0.07 per patient-year in the group treated with calcitonin and 0.45 per patient-year in the group treated with calcium (P < 0.001).
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied.
Summary · context
Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month.
Summary · context
The remaining 36 patients, aged 69.6 +/- 1.4 years (19 +/- 3 YSM), were given only 500 mg of elemental calcium for 10 days each month.
Report a problemFND-0775002002
02HumanNon-randomized trialEfficacy outcome
In postmenopausal osteoporotic women, salmon calcitonin reduced new fractures by 60% at 24 months.
In plain wordsIn postmenopausal osteoporotic women, new fractures decreased by 60% during salmon calcitonin treatment.
Peptide
Calcitonin-salmon
Outcome
DecreaseNumber of new fractures
Study
n = 36
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day for 10 days each month · intramuscular · 24 monthsAs given in this study (human).
Measurements
New fracture reduction
60%
calcitonin
Source sentences
Summary
At 24 months, the calcitonin group showed a 60% reduction in the number of new fractures and the group receiving only calcium had a 45% increase (P < 0.001).
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied.
Summary · context
Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month.
Summary · context
The remaining 36 patients, aged 69.6 +/- 1.4 years (19 +/- 3 YSM), were given only 500 mg of elemental calcium for 10 days each month.
Report a problemFND-0775002001
03HumanNon-randomized trialEfficacy outcome
In postmenopausal osteoporotic women, salmon calcitonin increased cortical bone mass by 12%.
In plain wordsIn postmenopausal osteoporotic women, salmon calcitonin increased cortical bone mass from baseline.
Peptide
Calcitonin-salmon
Outcome
IncreaseCortical bone mass
Study
n = 36
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day for 10 days each month · intramuscular · 24 monthsAs given in this study (human).
Measurements
Cortical bone mass change
12%
calcitonin
Source sentences
Summary
At 2 years, the calcitonin group showed a 12% increase in cortical bone mass on metacarpal radiogrammetry, a 16% increase in the axial skeleton on trunk densitometry, a 3.5% increase in total body bone mineral content, a 30.7% increase in pelvic bone mineral content, and a 6.2% increase in arm bone…
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied.
Summary · context
Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month.
Summary · context
The remaining 36 patients, aged 69.6 +/- 1.4 years (19 +/- 3 YSM), were given only 500 mg of elemental calcium for 10 days each month.
Report a problemFND-0775002003
04HumanNon-randomized trialEfficacy outcome
In postmenopausal osteoporotic women, salmon calcitonin increased axial skeleton bone mass by 16%.
In plain wordsIn postmenopausal osteoporotic women, salmon calcitonin increased axial skeleton bone mass from baseline.
Peptide
Calcitonin-salmon
Outcome
IncreaseAxial skeleton bone mass
Study
n = 36
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day for 10 days each month · intramuscular · 24 monthsAs given in this study (human).
Measurements
Axial skeleton change
16%
calcitonin
Source sentences
Summary
At 2 years, the calcitonin group showed a 12% increase in cortical bone mass on metacarpal radiogrammetry, a 16% increase in the axial skeleton on trunk densitometry, a 3.5% increase in total body bone mineral content, a 30.7% increase in pelvic bone mineral content, and a 6.2% increase in arm bone…
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied.
Summary · context
Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month.
Summary · context
The remaining 36 patients, aged 69.6 +/- 1.4 years (19 +/- 3 YSM), were given only 500 mg of elemental calcium for 10 days each month.
Report a problemFND-0775002004
05HumanNon-randomized trialEfficacy outcome
In postmenopausal osteoporotic women, salmon calcitonin increased total body bone mineral content by 3.5%.
In plain wordsIn postmenopausal osteoporotic women, salmon calcitonin increased total body bone mineral content from baseline.
Peptide
Calcitonin-salmon
Outcome
IncreaseTotal body bone mineral content
Study
n = 36
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day for 10 days each month · intramuscular · 24 monthsAs given in this study (human).
Measurements
Total body bone mineral content change
3.5%
calcitonin
Source sentences
Summary
At 2 years, the calcitonin group showed a 12% increase in cortical bone mass on metacarpal radiogrammetry, a 16% increase in the axial skeleton on trunk densitometry, a 3.5% increase in total body bone mineral content, a 30.7% increase in pelvic bone mineral content, and a 6.2% increase in arm bone…
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied.
Summary · context
Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month.
Summary · context
The remaining 36 patients, aged 69.6 +/- 1.4 years (19 +/- 3 YSM), were given only 500 mg of elemental calcium for 10 days each month.
Report a problemFND-0775002005
06HumanNon-randomized trialEfficacy outcome
In postmenopausal osteoporotic women, salmon calcitonin increased pelvic bone mineral content by 30.7%.
In plain wordsIn postmenopausal osteoporotic women, salmon calcitonin increased pelvic bone mineral content from baseline.
Peptide
Calcitonin-salmon
Outcome
IncreasePelvic bone mineral content
Study
n = 36
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day for 10 days each month · intramuscular · 24 monthsAs given in this study (human).
Measurements
Pelvic bone mineral content change
30.7%
calcitonin
Source sentences
Summary
At 2 years, the calcitonin group showed a 12% increase in cortical bone mass on metacarpal radiogrammetry, a 16% increase in the axial skeleton on trunk densitometry, a 3.5% increase in total body bone mineral content, a 30.7% increase in pelvic bone mineral content, and a 6.2% increase in arm bone…
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied.
Summary · context
Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month.
Summary · context
The remaining 36 patients, aged 69.6 +/- 1.4 years (19 +/- 3 YSM), were given only 500 mg of elemental calcium for 10 days each month.
Report a problemFND-0775002006
07HumanNon-randomized trialEfficacy outcome
In postmenopausal osteoporotic women, salmon calcitonin increased arm bone mineral content by 6.2%.
In plain wordsIn postmenopausal osteoporotic women, salmon calcitonin increased arm bone mineral content from baseline.
Peptide
Calcitonin-salmon
Outcome
IncreaseArm bone mineral content
Study
n = 36
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 IU/day for 10 days each month · intramuscular · 24 monthsAs given in this study (human).
Measurements
Arm bone mineral content change
6.2%
calcitonin
Source sentences
Summary
At 2 years, the calcitonin group showed a 12% increase in cortical bone mass on metacarpal radiogrammetry, a 16% increase in the axial skeleton on trunk densitometry, a 3.5% increase in total body bone mineral content, a 30.7% increase in pelvic bone mineral content, and a 6.2% increase in arm bone…
3 context sentences(design, population, supporting numbers)
Summary · context
Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied.
Summary · context
Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month.
Summary · context
The remaining 36 patients, aged 69.6 +/- 1.4 years (19 +/- 3 YSM), were given only 500 mg of elemental calcium for 10 days each month.
Report a problemFND-0775002007

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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