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Study · Animal study (in vivo) · guinea pig · 1995

3 results

Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action.

Fairhall KM, Mynett A, Robinson IC

The Journal of endocrinology1 Mar 1995Cited by 49 (Europe PMC)

PMID7738479 (opens in a new tab)DOI10.1677/joe.0.1440555 (opens in a new tab)PepBankPUB-07738479
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anaesthetized guinea pigs, intracerebroventricular GHRP‑6 stimulated GH release more than tenfold after 30-40 minutes.

    In plain wordsIn guinea pigs, GHRP‑6 injected into the brain increased growth hormone release more than tenfold after 30-40 minutes.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH release after central injection
    Study

    guinea pign: not reported in source

    Anaesthetized guinea pigs
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.04-1 microgram · intracerebroventricularAs given in this study (guinea pig).

    Measurements

    GH release
    > 10 fold
    30-40 min after i.c.v. injection

    Source sentences

    Summary
    GHRP-6 (0.04-1 microgram) stimulated GH release > 10-fold 30-40 min after i.c.v. injection.
    1 context sentence
    Summary · context
    To evaluate the central actions of this peptide, we have studied GH release in response to direct i.c.v. injections in anaesthetized guinea pigs.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In anaesthetized guinea pigs, intravenous GHRP‑6 required more than twentyfold the central dose for the same GH response.

    In plain wordsIn guinea pigs, intravenous GHRP‑6 required over twenty times the brain injection dose for the same growth hormone response.

    Peptide
    GHRP-6
    Outcome
    IncreaseDose required for equal GH response
    Study

    guinea pign: not reported in source

    Anaesthetized guinea pigs
    Comparator
    Intracerebroventricular GHRP-6
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (guinea pig).

    Source sentences

    Summary
    The same GH response required > 20-fold more GHRP-6 when given by i.v. injection.
    2 context sentences
    Summary · context
    GHRP-6 (0.04-1 microgram) stimulated GH release > 10-fold 30-40 min after i.c.v. injection.
    Summary · context
    To evaluate the central actions of this peptide, we have studied GH release in response to direct i.c.v. injections in anaesthetized guinea pigs.

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In anaesthetized guinea pigs, central Sandostatin pretreatment blocked GH release elicited by GHRP‑6.

    In plain wordsIn guinea pigs, Sandostatin injected into the brain before GHRP‑6 blocked the growth hormone response.

    Peptide
    GHRP-6
    Outcome
    DecreaseSomatostatin blockade of GHRP-6-induced GH release
    Study

    guinea pign: not reported in source

    Anaesthetized guinea pigs
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    A long acting somatostatin analogue (Sandostatin, SMS 201-995, 10 micrograms i.c.v.) (SMS) given 20 min before 200 ng GHRP-6 blocked GH release.
    1 context sentence
    Summary · context
    To evaluate the central actions of this peptide, we have studied GH release in response to direct i.c.v. injections in anaesthetized guinea pigs.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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