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Study · Randomized controlled trial · n = 18 · 1995

7 results

Growth hormone secretion after the administration of GHRP-6 or GHRH combined with GHRP-6 does not decline in late adulthood.

Micic D, Popovic V, Kendereski A, Macut D, Casanueva FF, Dieguez C

Clinical endocrinology1 Feb 1995Cited by 18 (Europe PMC)

PMID7734029 (opens in a new tab)DOI10.1111/j.1365-2265.1995.tb01861.x (opens in a new tab)PepBankPUB-07734029
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    GH responses to GHRP‑6 did not differ significantly between healthy young and older adults.

    In plain wordsGrowth hormone responses to GHRP‑6 were not significantly different between healthy young and older adults.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH response to GHRP-6, young versus older adults
    Study

    n = 18

    Comparator
    Young adults
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    90 micrograms · intravenous bolusAs given in this study (human).

    Source sentences

    Summary
    In contrast, GH responses to either GHRP-6 (F = 0.71, P = NS)
    3 context sentences
    Summary · context
    In order to gain a further insight into disrupted GH secretion in late adulthood, we evaluated GH responses to GHRP-6 or GHRH, administered either alone or in combination, in healthy young and late adulthood groups of subjects.
    Summary · context
    GHRH (100 micrograms), GHRP-6 (90 micrograms) either alone or in combination were administered as an i.v. bolus.
    Summary · context
    Groups of healthy young (mean +/- SEM 22 +/- 1.1 years, n = 9) and older adult subjects (59.5 +/- 1.7 years, n = 9) were studied.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy young adults, GHRH plus GHRP‑6 elicited a greater GH increase than GHRH alone.

    In plain wordsIn healthy young adults, GHRH with GHRP‑6 raised growth hormone more than GHRH alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response to GHRH plus GHRP-6 versus GHRH alone, young adults
    Study

    n = 9

    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    90 micrograms · intravenous bolusAs given in this study (human).

    Source sentences

    Summary
    In the group of young adult subjects the combined administration of GHRH and GHRP-6 elicited a greater GH increase than GHRH alone (F = 21.9, P < 0.001) or GHRP-6 alone (F = 6.2, P = 0.01).
    3 context sentences
    Summary · context
    In order to gain a further insight into disrupted GH secretion in late adulthood, we evaluated GH responses to GHRP-6 or GHRH, administered either alone or in combination, in healthy young and late adulthood groups of subjects.
    Summary · context
    GHRH (100 micrograms), GHRP-6 (90 micrograms) either alone or in combination were administered as an i.v. bolus.
    Summary · context
    Groups of healthy young (mean +/- SEM 22 +/- 1.1 years, n = 9) and older adult subjects (59.5 +/- 1.7 years, n = 9) were studied.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy older adults, GHRH plus GHRP‑6 produced a greater GH response than GHRH alone.

    In plain wordsIn healthy older adults, GHRH with GHRP‑6 raised growth hormone more than GHRH alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response to GHRH plus GHRP-6 versus GHRH alone, late adulthood
    Study

    n = 9

    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    90 micrograms · intravenous bolusAs given in this study (human).

    Source sentences

    Summary
    Similarly, the response to the combined stimuli was also greater than with GHRH alone (F = 21.8, P < 0.001) or GHRP-6 alone (F = 23.9, P < 0.001) in the late adulthood group of subjects.
    3 context sentences
    Summary · context
    In order to gain a further insight into disrupted GH secretion in late adulthood, we evaluated GH responses to GHRP-6 or GHRH, administered either alone or in combination, in healthy young and late adulthood groups of subjects.
    Summary · context
    GHRH (100 micrograms), GHRP-6 (90 micrograms) either alone or in combination were administered as an i.v. bolus.
    Summary · context
    Groups of healthy young (mean +/- SEM 22 +/- 1.1 years, n = 9) and older adult subjects (59.5 +/- 1.7 years, n = 9) were studied.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy older adults, GH responses to GHRP‑6 were much greater than to GHRH.

    In plain wordsIn healthy older adults, GHRP‑6 raised growth hormone much more than GHRH did.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response to GHRP-6 versus GHRH, late adulthood
    Study

    n = 9

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    90 micrograms · intravenous bolusAs given in this study (human).

    Source sentences

    Summary
    These data show that GH responses to GHRP-6 are much greater than to GHRH in late adulthood.
    3 context sentences
    Summary · context
    In order to gain a further insight into disrupted GH secretion in late adulthood, we evaluated GH responses to GHRP-6 or GHRH, administered either alone or in combination, in healthy young and late adulthood groups of subjects.
    Summary · context
    GHRH (100 micrograms), GHRP-6 (90 micrograms) either alone or in combination were administered as an i.v. bolus.
    Summary · context
    Groups of healthy young (mean +/- SEM 22 +/- 1.1 years, n = 9) and older adult subjects (59.5 +/- 1.7 years, n = 9) were studied.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 05HumanNot a test of GHRP-6 aloneRandomized controlled trialEfficacy outcome

    GH responses to combined GHRH plus GHRP‑6 did not differ significantly between healthy young and older adults.

    In plain wordsGrowth hormone responses to GHRH with GHRP‑6 were not significantly different between healthy young and older adults.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH response to GHRH plus GHRP-6, young versus older adults
    Study

    n = 18

    Comparator
    Young adults
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    or combined GHRH plus GHRP-6 administration (F = 0.68, P = NS) were not significantly different between the two groups.
    3 context sentences
    Summary · context
    In order to gain a further insight into disrupted GH secretion in late adulthood, we evaluated GH responses to GHRP-6 or GHRH, administered either alone or in combination, in healthy young and late adulthood groups of subjects.
    Summary · context
    GHRH (100 micrograms), GHRP-6 (90 micrograms) either alone or in combination were administered as an i.v. bolus.
    Summary · context
    Groups of healthy young (mean +/- SEM 22 +/- 1.1 years, n = 9) and older adult subjects (59.5 +/- 1.7 years, n = 9) were studied.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 06HumanNot a test of GHRP-6 aloneRandomized controlled trialEfficacy outcome

    In healthy young adults, GHRH plus GHRP‑6 elicited a greater GH increase than GHRP‑6 alone.

    In plain wordsIn healthy young adults, GHRH with GHRP‑6 raised growth hormone more than GHRP‑6 alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response to GHRH plus GHRP-6 versus GHRP-6 alone, young adults
    Study

    n = 9

    Comparator
    GHRP-6 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    In the group of young adult subjects the combined administration of GHRH and GHRP-6 elicited a greater GH increase than GHRH alone (F = 21.9, P < 0.001) or GHRP-6 alone (F = 6.2, P = 0.01).
    3 context sentences
    Summary · context
    In order to gain a further insight into disrupted GH secretion in late adulthood, we evaluated GH responses to GHRP-6 or GHRH, administered either alone or in combination, in healthy young and late adulthood groups of subjects.
    Summary · context
    GHRH (100 micrograms), GHRP-6 (90 micrograms) either alone or in combination were administered as an i.v. bolus.
    Summary · context
    Groups of healthy young (mean +/- SEM 22 +/- 1.1 years, n = 9) and older adult subjects (59.5 +/- 1.7 years, n = 9) were studied.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 07HumanNot a test of GHRP-6 aloneRandomized controlled trialEfficacy outcome

    In healthy older adults, GHRH plus GHRP‑6 produced a greater GH response than GHRP‑6 alone.

    In plain wordsIn healthy older adults, GHRH with GHRP‑6 raised growth hormone more than GHRP‑6 alone.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response to GHRH plus GHRP-6 versus GHRP-6 alone, late adulthood
    Study

    n = 9

    Comparator
    GHRP-6 alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Similarly, the response to the combined stimuli was also greater than with GHRH alone (F = 21.8, P < 0.001) or GHRP-6 alone (F = 23.9, P < 0.001) in the late adulthood group of subjects.
    3 context sentences
    Summary · context
    In order to gain a further insight into disrupted GH secretion in late adulthood, we evaluated GH responses to GHRP-6 or GHRH, administered either alone or in combination, in healthy young and late adulthood groups of subjects.
    Summary · context
    GHRH (100 micrograms), GHRP-6 (90 micrograms) either alone or in combination were administered as an i.v. bolus.
    Summary · context
    Groups of healthy young (mean +/- SEM 22 +/- 1.1 years, n = 9) and older adult subjects (59.5 +/- 1.7 years, n = 9) were studied.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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