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Study · Animal study (in vivo) · rat · 1995

4 results

Central actions of peptide and non-peptide growth hormone secretagogues in the rat.

Dickson SL, Leng G, Dyball RE, Smith RG

Neuroendocrinology1 Jan 1995Cited by 63 (Europe PMC)

PMID7731496 (opens in a new tab)DOI10.1159/000126825 (opens in a new tab)PepBankPUB-07731496
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, intracerebroventricular GHRP‑6 induced dense ventral arcuate nuclear Fos staining compared with vehicle.

    In plain wordsIn rats, GHRP‑6 injected into the brain increased ventral arcuate Fos staining compared with vehicle.

    Peptide
    GHRP-6
    Outcome
    IncreaseArcuate nuclear Fos staining versus vehicle
    Study

    ratn: not reported in source

    Conscious male rats
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Dense nuclear Fos staining was induced throughout the ventral arcuate nucleus of rats injected intracerebroventricularly with low doses of GHRP-6 but not in rats injected with the endogenous GH-releasing hormone GHRH or in vehicle-treated controls.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, intracerebroventricular GHRP‑6 induced dense ventral arcuate nuclear Fos staining that GHRH did not induce.

    In plain wordsIn rats, GHRP‑6 injected into the brain induced ventral arcuate Fos staining, whereas GHRH did not.

    Peptide
    GHRP-6
    Outcome
    IncreaseArcuate nuclear Fos staining versus GHRH
    Study

    ratn: not reported in source

    Comparator
    GHRH
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Dense nuclear Fos staining was induced throughout the ventral arcuate nucleus of rats injected intracerebroventricularly with low doses of GHRP-6 but not in rats injected with the endogenous GH-releasing hormone GHRH or in vehicle-treated controls.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In anaesthetized male rats, intravenous GHRP‑6 predominantly excited putative neuroendocrine arcuate cells.

    In plain wordsIn anaesthetized rats, intravenous GHRP‑6 mainly increased activity in presumed neuroendocrine arcuate cells.

    Peptide
    GHRP-6
    Outcome
    IncreasePutative neuroendocrine neuronal activity
    Study

    ratn: not reported in source

    Pentobarbitone-anaesthetized male rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    In pentobarbitone-anaesthetized male rats, the effects of intravenous injection of GHRP-6 on the electrical activity of arcuate neurones was predominantly excitatory for putative neuroendocrine cells and inhibitory for the remaining unidentified cells.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In anaesthetized male rats, intravenous GHRP‑6 predominantly inhibited the remaining unidentified arcuate cells.

    In plain wordsIn anaesthetized rats, intravenous GHRP‑6 mainly reduced activity in the other unidentified arcuate cells.

    Peptide
    GHRP-6
    Outcome
    DecreaseUnidentified arcuate neuronal activity
    Study

    ratn: not reported in source

    Pentobarbitone-anaesthetized male rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    In pentobarbitone-anaesthetized male rats, the effects of intravenous injection of GHRP-6 on the electrical activity of arcuate neurones was predominantly excitatory for putative neuroendocrine cells and inhibitory for the remaining unidentified cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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