Luteinizing hormone-releasing hormone agonist inhibits cyclophosphamide-induced ovarian follicular depletion in rhesus monkeys.

Ataya K, Rao LV, Lawrence E, Kimmel R

Biology of reproduction1 Feb 1995Cited by 179 (Europe PMC)

PMID7711205DOI10.1095/biolreprod52.2.365PepBankPUB-07711205

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys, primordial follicle loss was lower with Lupron plus cyclophosphamide than cyclophosphamide control (28.9 +/- 9.1% versus 64.6 +/- 2.8%, p < 0.05).
In plain wordsIn rhesus monkeys, leuprolide reduced primordial follicle loss compared with cyclophosphamide control.
Peptide
Leuprolide
Outcome
DecreasePrimordial follicle loss
Study
rhesus monkeyn = 6
Adult female rhesus monkeys receiving cyclophosphamide after unilateral ovariectomy
Comparator
Cyclophosphamide plus placebo vehicle
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · injectionAs given in this study (rhesus monkey).
Measurements
Primordial follicle loss
28.9%
Lupron plus cyclophosphamide
Primordial follicle loss
64.6%
cyclophosphamide control
Source sentences
Summary
During the treatment period, 64.6 +/- 2.8% of the total primordial follicles were lost in the CTX group compared to only 28.9 +/- 9.1% in the LHRHa+CTX group (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Six adult female rhesus monkeys underwent unilateral ovariectomy and were divided into two groups that received monthly injections of either Lupron depot (LHRHa) or placebo vehicle.
Summary · context
Both groups received cyclophosphamide (CTX) injections.
Report a problemFND-0771120502
02AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys, daily follicle decline was lower with Lupron plus cyclophosphamide than cyclophosphamide control (0.057 +/- 0.019 versus 0.120 +/- 0.012, p < 0.05).
In plain wordsIn rhesus monkeys, daily follicle loss was lower with leuprolide than cyclophosphamide control.
Peptide
Leuprolide
Outcome
DecreaseDaily primordial follicle decline
Study
rhesus monkeyn = 6
Adult female rhesus monkeys receiving cyclophosphamide after unilateral ovariectomy
Comparator
Cyclophosphamide plus placebo vehicle
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · injectionAs given in this study (rhesus monkey).
Measurements
Daily follicle decline
0.057 % per day
Lupron plus cyclophosphamide
Daily follicle decline
0.12 % per day
cyclophosphamide control
Source sentences
Summary
The percentage rate of decline per day was 0.120 +/- 0.012 for the CTX group compared to 0.057 +/- 0.019 (p < 0.05) for the LHRHa+CTX group.
2 context sentences(design, population, supporting numbers)
Summary · context
Six adult female rhesus monkeys underwent unilateral ovariectomy and were divided into two groups that received monthly injections of either Lupron depot (LHRHa) or placebo vehicle.
Summary · context
Both groups received cyclophosphamide (CTX) injections.
Report a problemFND-0771120503
03AnimalAnimal study (in vivo)Efficacy outcome
In rhesus monkeys receiving cyclophosphamide, mean serum FSH decreased significantly during Lupron depot treatment.
In plain wordsIn rhesus monkeys receiving cyclophosphamide, FSH decreased significantly during leuprolide treatment.
Peptide
Leuprolide
Outcome
DecreaseSerum FSH
Study
rhesus monkeyn: not reported in source
Adult female rhesus monkeys receiving cyclophosphamide after unilateral ovariectomy
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · injectionAs given in this study (rhesus monkey).
Source sentences
Summary
Mean serum FSH levels significantly increased in the CTX group and significantly decreased in the LHRHa+CTX group.
2 context sentences(design, population, supporting numbers)
Summary · context
Six adult female rhesus monkeys underwent unilateral ovariectomy and were divided into two groups that received monthly injections of either Lupron depot (LHRHa) or placebo vehicle.
Summary · context
Both groups received cyclophosphamide (CTX) injections.
Report a problemFND-0771120501

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 stopped early · source ClinicalTrials.gov (opens in a new tab)

WithdrawnPhase 3NCT00888082

Protection of Ovarian Function With Goserelin Acetate in Premenopausal Early Breast Cancer Patients With Chemotherapy

AstraZenecan = 102Completion est. Apr 2012

Breast Cancer · Ovarian Function

Trial page ClinicalTrials.govUpdated 10 Dec 2010

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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