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Study · Animal study (in vivo) · chicken · 1994

4 results

Oxytocin antagonist blocks the vasodepressor but not the vasopressor effect of neurohypophysial peptides in chickens.

Robinzon B, Koike TI, Marks PA

Peptides1 Jan 1994Cited by 15 (Europe PMC)

PMID7700844 (opens in a new tab)DOI10.1016/0196-9781(94)90116-3 (opens in a new tab)PepBankPUB-07700844
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cockerels, intravenous oxytocin had a short-lasting vasodepressor effect, with potency in the order OT = MT > AVT > AVP.

    In plain wordsIn chickens, oxytocin briefly lowered blood pressure, with potency like mesotocin and above vasotocin and vasopressin.

    Peptide
    Oxytocin
    Outcome
    DecreaseVasodepressor effect
    Study

    chickenn: not reported in source

    cockerels with arterial and venous cannulas in slings
    Comparator
    Other neurohypophysial peptides
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    2 nmol/kg · intravenous · six injections at 6-min intervalsAs given in this study (chicken).

    Source sentences

    Summary
    Arginine vasopressin (AVP), oxytocin (OT), and mesotocin (MT) had short-lasting VDP effect in the following order of potency: OT = MT > AVT > AVP.
    2 context sentences
    Summary · context
    Cockerels with permanent cannulas in the brachial artery and vein were put into isolated slings.
    Summary · context
    In each cockerel 2 nmol/kg of the tested neurohypophysial peptide (NPs) or analogue was IV injected six times at 6-min intervals.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In cockerels, oxytocin did not cause a vasopressor response; only AVT and AVP did.

    In plain wordsIn chickens, oxytocin did not raise blood pressure; only vasotocin and vasopressin did.

    Peptide
    Oxytocin
    Outcome
    No significant changeVasopressor response
    Study

    chickenn: not reported in source

    cockerels with arterial and venous cannulas in slings
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    2 nmol/kg · intravenous · six injections at 6-min intervalsAs given in this study (chicken).

    Source sentences

    Summary
    Only AVT and, more effectively, AVP, caused a VP response.
    2 context sentences
    Summary · context
    Cockerels with permanent cannulas in the brachial artery and vein were put into isolated slings.
    Summary · context
    In each cockerel 2 nmol/kg of the tested neurohypophysial peptide (NPs) or analogue was IV injected six times at 6-min intervals.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In cockerels, the vasodepressor effect of oxytocin declined on repeated injections.

    In plain wordsIn chickens, the blood pressure lowering effect of oxytocin became smaller with repeated injections.

    Peptide
    Oxytocin
    Outcome
    DecreaseVasodepressor effect on repeated injection
    Study

    chickenn: not reported in source

    cockerels with arterial and venous cannulas in slings
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    2 nmol/kg · intravenous · six injections at 6-min intervalsAs given in this study (chicken).

    Source sentences

    Summary
    The VDP effect of MT and OT declined on repeated injections.
    2 context sentences
    Summary · context
    Cockerels with permanent cannulas in the brachial artery and vein were put into isolated slings.
    Summary · context
    In each cockerel 2 nmol/kg of the tested neurohypophysial peptide (NPs) or analogue was IV injected six times at 6-min intervals.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In cockerels, pretreatment with an oxytocin antagonist abolished the vasodepressor effect of all tested neurohypophysial peptides.

    In plain wordsIn chickens, an oxytocin blocker removed the blood pressure lowering effect of all tested neurohypophysial peptides, oxytocin included.

    Peptide
    Oxytocin
    Outcome
    DecreaseVasodepressor effect after oxytocin antagonist pretreatment
    Study

    chickenn: not reported in source

    cockerels with arterial and venous cannulas in slings
    Comparator
    No antagonist
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Pretreatment with OT antagonist, [d(CH2)5-O-Me-Tyr2-Thr4.Tyr9.Orn8]VT, abolished the VDP effect of all NPs.
    2 context sentences
    Summary · context
    Cockerels with permanent cannulas in the brachial artery and vein were put into isolated slings.
    Summary · context
    In each cockerel 2 nmol/kg of the tested neurohypophysial peptide (NPs) or analogue was IV injected six times at 6-min intervals.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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