Effect of vasoactive intestinal polypeptide on porcine gastrointestinal electrical activity.

Wechsung E, Houvenaghel A

Peptides1 Jan 1994Cited by 2 (Europe PMC)

PMID7700839DOI10.1016/0196-9781(94)90111-2PepBankPUB-07700839

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In conscious piglets, intravenous VIP at both doses decreased antral electrical activity.
In plain wordsIn piglets, VIP given into a vein reduced the electrical activity of the stomach outlet at both doses.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseAntral electrical activity
Study
pign: not reported in source
conscious piglets with implanted electrodes
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
150 and 300 pmol/kg/min · intravenous infusionAs given in this study (pig).
Source sentences
Summary
Both doses resulted in a decrease in antral electrical activity.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intravenous infusion of VIP, 150 and 300 pmol/kg/min, on gastrointestinal electrical activity was studied in conscious piglets with electrodes implanted in the wall of the antrum pylori, duodenum, jejunum, and ileum.
Report a problemFND-0770083901
02AnimalAnimal study (in vivo)Efficacy outcome
In conscious piglets, the lower VIP dose shortened the irregular spiking activity phase in the jejunum and ileum.
In plain wordsIn piglets, the lower VIP dose shortened a phase of electrical activity in the small intestine.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseIrregular spiking activity phase in jejunum and ileum, lower dose
Study
pign: not reported in source
conscious piglets with implanted electrodes
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
150 pmol/kg/min · intravenous infusionAs given in this study (pig).
Source sentences
Summary
In the small intestine, only the lower dose caused a shortening of the irregular spiking activity phase in the jejunum and ileum.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intravenous infusion of VIP, 150 and 300 pmol/kg/min, on gastrointestinal electrical activity was studied in conscious piglets with electrodes implanted in the wall of the antrum pylori, duodenum, jejunum, and ileum.
Report a problemFND-0770083902
03AnimalAnimal study (in vivo)Efficacy outcome
In conscious piglets, the higher VIP dose did not change the irregular spiking activity phase in the small intestine; only the lower dose did.
In plain wordsIn piglets, the higher VIP dose did not change this phase of small-intestine activity; only the lower dose did.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeIrregular spiking activity phase in jejunum and ileum, higher dose
Study
pign: not reported in source
conscious piglets with implanted electrodes
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
300 pmol/kg/min · intravenous infusionAs given in this study (pig).
Source sentences
Summary
In the small intestine, only the lower dose caused a shortening of the irregular spiking activity phase in the jejunum and ileum.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intravenous infusion of VIP, 150 and 300 pmol/kg/min, on gastrointestinal electrical activity was studied in conscious piglets with electrodes implanted in the wall of the antrum pylori, duodenum, jejunum, and ileum.
Report a problemFND-0770083903
04AnimalAnimal study (in vivo)Efficacy outcome
In conscious piglets, the lower VIP dose reduced the migrating motor complex interval in the jejunum.
In plain wordsIn piglets, the lower VIP dose shortened the interval between waves of intestinal activity in the jejunum.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseMMC interval in jejunum
Study
pign: not reported in source
conscious piglets with implanted electrodes
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
150 pmol/kg/min · intravenous infusionAs given in this study (pig).
Source sentences
Summary
In the small intestine, only the lower dose caused a shortening of the irregular spiking activity phase in the jejunum and ileum. In the jejunum this resulted in a reduction of the MMC interval.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of intravenous infusion of VIP, 150 and 300 pmol/kg/min, on gastrointestinal electrical activity was studied in conscious piglets with electrodes implanted in the wall of the antrum pylori, duodenum, jejunum, and ileum.
Report a problemFND-0770083904

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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