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Study · Measured the body's own peptide · 1994

3 results

Decreased delta-sleep and plasma delta-sleep-inducing peptide in patients with Cushing syndrome.

Friedman TC, García-Borreguero D, Hardwick D, Akuete CN, Doppman JL, Dorn LD, Barker CN, Yanovski JA, Chrousos GP

Neuroendocrinology1 Dec 1994Cited by 19 (Europe PMC)

PMID7700506 (opens in a new tab)DOI10.1159/000126806 (opens in a new tab)PepBankPUB-07700506
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with Cushing syndrome, plasma DSIP-like immunoreactivity at 08.00 h was significantly lower than in normal volunteers.

    In plain wordsIn people with Cushing syndrome, the body's own DSIP-like levels were lower than in healthy volunteers.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreasePlasma DSIP-LI at 08.00 h
    Study

    n = 114

    Comparator
    Normal volunteers
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Measurements

    DSIP-LI at 08.00 h
    797 pmol/l
    Cushing syndrome
    DSIP-LI at 08.00 h
    1.062 pmol/l
    normal volunteers

    Source sentences

    Summary
    The 08.00 h DSIP-LI concentrations of 797 +/- 57 pmol/l (mean +/- SEM) in the patients with Cushing syndrome were significantly reduced compared to the level of 1,062 +/- 99 pmol/l found in the normal volunteers (p < 0.05)
    2 context sentences
    Summary · context
    In study 2, we measured plasma levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) at 08.00 h in 65 patients with Cushing syndrome and 49 normal volunteers.
    Summary · context
    To evaluate the sleep disturbances of patients with Cushing syndrome and to examine the relationship between the sleep disturbances and plasma levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI), we performed three polysomnographic/endocrinological studies in patients with Cushing syndrome.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In patients with Cushing syndrome, the circadian rhythm of plasma DSIP-LI was similar to that in normal volunteers.

    In plain wordsIn people with Cushing syndrome, the daily rhythm of the body's own DSIP-like levels was similar to that in healthy volunteers.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeCircadian rhythm of plasma DSIP-LI
    Study

    n = 21

    Comparator
    Normal volunteers
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The circadian rhythm of plasma DSIP-LI was found to be similar in Cushing patients and normal volunteers.
    2 context sentences
    Summary · context
    In addition, DSIP-LI was measured every 30 min for 24 h in 9 patients with Cushing syndrome and 12 normal volunteers.
    Summary · context
    To evaluate the sleep disturbances of patients with Cushing syndrome and to examine the relationship between the sleep disturbances and plasma levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI), we performed three polysomnographic/endocrinological studies in patients with Cushing syndrome.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In patients with Cushing syndrome, the amount of delta sleep correlated negatively with 08.00 h DSIP-LI.

    In plain wordsIn people with Cushing syndrome, more delta sleep was linked to lower body's own DSIP-like levels; this does not show cause.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableCorrelation between delta sleep amount and 08.00 h DSIP-LI
    Study

    n: not reported in source

    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Measurements

    Correlation coefficient r
    −0.43 r
    delta sleep vs 08.00 h DSIP-LI

    Source sentences

    Summary
    There was a significant negative correlation between amount of delta sleep and 08.00 h DSIP-LI (r = -0.43, p < 0.05), which is against the notion of a causal relationship between DSIP-LI and delta sleep.
    1 context sentence
    Summary · context
    To evaluate the sleep disturbances of patients with Cushing syndrome and to examine the relationship between the sleep disturbances and plasma levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI), we performed three polysomnographic/endocrinological studies in patients with Cushing syndrome.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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