Stimulus-induced depletion of pro-enkephalins, oxytocin and vasopressin and pro-enkephalin interaction with posterior pituitary hormone release in vitro.

Leng G, Bicknell RJ, Brown D, Bowden C, Chapman C, Russell JA

Neuroendocrinology1 Dec 1994Cited by 13 (Europe PMC)

PMID7700499DOI10.1159/000126797PepBankPUB-07700499

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, acute stimulation of the neural lobe in vivo depleted the neural lobe content of the body's own oxytocin.
In plain wordsIn rats, stimulating the pituitary neural lobe lowered its stored natural oxytocin.
Peptide
Oxytocin
Outcome
DecreaseNeural lobe oxytocin content after stimulation
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
We now report that acute stimulation of the rat neural lobe in vivo results in depletion of the neural lobe content of OXT, AVP, dynorphin A1-17, dynorphin A1-8 and metenkephalin (Met-Enk).
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0770049901
02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, correlation analysis suggested that a significant portion of neural lobe dynorphin is co-secreted with the body's own oxytocin.
In plain wordsIn rats, part of the stored dynorphin seemed to be released together with the body's own oxytocin.
Peptide
Oxytocin
Outcome
Not applicableCo-secretion of dynorphin with oxytocin
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
The dynorphin content is depleted to a similar extent as that of OXT and AVP; a correlation analysis suggests that while most dynorphin is co-secreted with AVP, a significant portion is co-secreted with OXT, consistent with a co-localisation of dynorphin with OXT.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0770049902
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, naloxone-precipitated opioid withdrawal with selective hypersecretion of the body's own oxytocin also depleted Met-Enk, suggesting co-secretion of the two.
In plain wordsIn rats, opioid withdrawal that raised release of natural oxytocin also lowered stored Met-Enk, which suggests joint release.
Peptide
Oxytocin
Outcome
Not applicableMet-enkephalin depletion with selective oxytocin hypersecretion
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
However, depletion of Met-Enk was also observed following naloxone-precipitated opioid withdrawal accompanying selective hypersecretion of OXT, suggesting co-secretion of OXT and Met-Enk.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0770049903

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

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