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Study · Not a test of the peptide alone · 1994

2 results

Reduction of responses to angiotensin II by antidepressant drugs.

Gard PR, Mandy A, Whiting JM, Nickels DP, Meakin AJ

European journal of pharmacology1 Nov 1994Cited by 15 (Europe PMC)

PMID7698168 (opens in a new tab)DOI10.1016/0014-2999(94)00481-1 (opens in a new tab)PepBankPUB-07698168
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In isolated rat uterus, desipramine, fluoxetine, tranylcypromine and cocaine each reduced the contractile response to oxytocin.

    In plain wordsIn lab tests on rat uterus, antidepressants and cocaine reduced the response to oxytocin. Oxytocin served only as a test tool.

    Peptide
    Oxytocin
    Outcome
    DecreaseUterine contractile response to oxytocin
    Study

    ratn: not reported in source

    isolated rat uterus
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    In vitro, all of the drugs reduced the effects of not only angiotensin but also acetylcholine and oxytocin on the uterus.
    1 context sentence
    Summary · context
    The effects of the antidepressant drugs desipramine, fluoxetine and tranylcypromine and the non-antidepressant control cocaine on angiotensin II function were determined in vivo by use of angiotensin-induced drinking in rats and in vitro using contractile responses of the rat uterus.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In isolated rat uterus, the inhibition by the drugs of the responses to angiotensin, acetylcholine and oxytocin appeared non-competitive in all cases.

    In plain wordsIn lab tests on rat uterus, the drugs blocked the responses in a non-competitive way. Oxytocin served only as a test tool.

    Peptide
    Oxytocin
    Outcome
    Not applicableType of inhibition of uterine responses
    Study

    ratn: not reported in source

    isolated rat uterus
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    The inhibition appeared to be non-competitive in all cases.
    2 context sentences
    Summary · context
    In vitro, all of the drugs reduced the effects of not only angiotensin but also acetylcholine and oxytocin on the uterus.
    Summary · context
    The effects of the antidepressant drugs desipramine, fluoxetine and tranylcypromine and the non-antidepressant control cocaine on angiotensin II function were determined in vivo by use of angiotensin-induced drinking in rats and in vitro using contractile responses of the rat uterus.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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