Plasma clearance and tissue distribution of labelled insulin-like growth factor-I (IGF-I) and an analogue LR3IGF-I in pregnant rats.

Bastian SE, Walton PE, Wallace JC, Ballard FJ

The Journal of endocrinology1 Aug 1993Cited by 27 (Europe PMC)

PMID7693845DOI10.1677/joe.0.1380327PepBankPUB-07693845

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Pharmacokinetics
In rats, LR3IGF-I was cleared from plasma more rapidly than IGF-I.
In plain wordsIn rats, LR3IGF-I left the blood faster than regular IGF-I.
Peptide
IGF-1 LR3
Outcome
IncreasePlasma clearance of LR3IGF-I compared with IGF-I
Study
ratn: not reported in source
Catheterized virgin and day-18 pregnant rats
Comparator
IGF-I
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · intravenous bolusAs given in this study (rat).
Source sentences
Summary
Although LR3IGF-I was cleared more rapidly than IGF-I from plasma
1 context sentence(design, population, supporting numbers)
Summary · context
Intravenous boluses of radiolabelled growth factors were administered to catheterized virgin and age-matched pregnant rats on day 18 of gestation when plasma IGFBPs, in particular IGFBP-3, are dramatically reduced.
Report a problemFND-0769384501
02AnimalAnimal study (in vivo)Pharmacokinetics
In rats, LR3IGF-I clearance rates were similar in pregnant and virgin animals.
In plain wordsIn rats, LR3IGF-I cleared from the blood at a similar rate in pregnant and non-pregnant animals.
Peptide
IGF-1 LR3
Outcome
No significant changeLR3IGF-I metabolic clearance rate, pregnant versus virgin rats
Study
ratn: not reported in source
Catheterized virgin and day-18 pregnant rats
Comparator
Virgin rats
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · intravenous bolusAs given in this study (rat).
Measurements
Metabolic clearance rate
9.19 ml/min per kg
pregnant rats
Metabolic clearance rate
9.84 ml/min per kg
virgin rats
Source sentences
Summary
similar clearance rates for the analogue were obtained in both pregnant and virgin animals, MCR = 9.19 +/- 0.15 and 9.84 +/- 0.28 ml/min per kg respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Intravenous boluses of radiolabelled growth factors were administered to catheterized virgin and age-matched pregnant rats on day 18 of gestation when plasma IGFBPs, in particular IGFBP-3, are dramatically reduced.
Report a problemFND-0769384502
03AnimalAnimal study (in vivo)Pharmacokinetics
In rat plasma, the majority of LR3IGF-I was detected as free peptide.
In plain wordsIn rats, most LR3IGF-I in the blood was free and not bound to carrier proteins.
Peptide
IGF-1 LR3
Outcome
Not applicablePlasma binding form of LR3IGF-I
Study
ratn: not reported in source
Catheterized virgin and day-18 pregnant rats
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · intravenous bolusAs given in this study (rat).
Source sentences
Summary
The majority of LR3IGF-I was detected as free peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
Intravenous boluses of radiolabelled growth factors were administered to catheterized virgin and age-matched pregnant rats on day 18 of gestation when plasma IGFBPs, in particular IGFBP-3, are dramatically reduced.
Report a problemFND-0769384503
04AnimalAnimal study (in vivo)Pharmacokinetics
In rats, a larger proportion of tracer was found as small breakdown products in plasma when LR3IGF-I was the labelled tracer, which suggests greater degradation.
In plain wordsIn rats, more of the LR3IGF-I tracer appeared as small breakdown products, which suggests faster degradation.
Peptide
IGF-1 LR3
Outcome
IncreasePlasma breakdown products with LR3IGF-I tracer
Study
ratn: not reported in source
Catheterized virgin and day-18 pregnant rats
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · intravenous bolusAs given in this study (rat).
Source sentences
Summary
A larger proportion of the tracer was detected as small M(r) breakdown products in plasma from rats under conditions of reduced binding to IGFBPs, e.g. during pregnancy or when LR3IGF-I was the labelled tracer, suggesting greater rates of IGF degradation.
1 context sentence(design, population, supporting numbers)
Summary · context
Intravenous boluses of radiolabelled growth factors were administered to catheterized virgin and age-matched pregnant rats on day 18 of gestation when plasma IGFBPs, in particular IGFBP-3, are dramatically reduced.
Report a problemFND-0769384504
05AnimalAnimal study (in vivo)Pharmacokinetics
In rats, more LR3IGF-I than IGF-I tracer was detected in kidneys, ovaries and adrenals of virgin rats and in ovaries and adrenals of pregnant rats.
In plain wordsIn rats, more LR3IGF-I than regular IGF-I reached the kidneys, ovaries and adrenals.
Peptide
IGF-1 LR3
Outcome
IncreaseTissue distribution: kidneys, ovaries and adrenals
Study
ratn: not reported in source
Catheterized virgin and day-18 pregnant rats
Comparator
IGF-I
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · intravenous bolusAs given in this study (rat).
Source sentences
Summary
More LR3IGF-I tracer was detected in kidneys, ovaries and adrenals of virgin rats and in the ovaries and adrenals of pregnant rats, compared with IGF-I tracer.
1 context sentence(design, population, supporting numbers)
Summary · context
Intravenous boluses of radiolabelled growth factors were administered to catheterized virgin and age-matched pregnant rats on day 18 of gestation when plasma IGFBPs, in particular IGFBP-3, are dramatically reduced.
Report a problemFND-0769384505
06AnimalAnimal study (in vivo)Pharmacokinetics
In rats, less LR3IGF-I than IGF-I tracer was detected in caecum, brain, liver and heart of virgin rats, and in kidneys, caecum, brain, liver, heart, placenta, fetus and fetal plasma of pregnant rats.
In plain wordsIn rats, less LR3IGF-I than regular IGF-I reached the gut, brain, liver, heart, placenta and fetus.
Peptide
IGF-1 LR3
Outcome
DecreaseTissue distribution: caecum, brain, liver, heart, placenta and fetus
Study
ratn: not reported in source
Catheterized virgin and day-18 pregnant rats
Comparator
IGF-I
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · intravenous bolusAs given in this study (rat).
Source sentences
Summary
IGF-I radioactivity was greater than LR3IGF-I in caecum, brain, liver and heart in virgin rats and in kidneys, caecum, brain, liver, heart, placenta, fetus and fetal plasma of the pregnant rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Intravenous boluses of radiolabelled growth factors were administered to catheterized virgin and age-matched pregnant rats on day 18 of gestation when plasma IGFBPs, in particular IGFBP-3, are dramatically reduced.
Report a problemFND-0769384506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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