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Study · In vitro (cells) · rat · 1993

5 results

Effect of pituitary adenylate cyclase activating polypeptide on vasopressin-induced proliferation of aortic smooth muscle cells: comparison with vasoactive intestinal polypeptide.

Oiso Y, Kotoyori J, Murase T, Ito Y, Kozawa O

Biochemistry and cell biology = Biochimie et biologie cellulaire1 Mar 1993Cited by 11 (Europe PMC)

PMID7691092 (opens in a new tab)DOI10.1139/o93-025 (opens in a new tab)PepBankPUB-07691092
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured rat aortic smooth muscle cells, VIP inhibited arginine vasopressin-stimulated DNA synthesis in a dose-dependent and cell-cycle-dependent way, with a maximum at late G1.

    In plain wordsIn cells from rat aorta, VIP reduced vasopressin-driven DNA synthesis as the dose rose, most strongly at late G1 phase.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseAVP-stimulated DNA synthesis
    Study

    ratn: not reported in source

    cultured rat aortic smooth muscle cells
    Comparator
    AVP alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vasoactive intestinal polypeptide (VIP), which shows a considerable homology with PACAP, also inhibited dose dependently the AVP-induced DNA synthesis in a cell cycle dependent manner. The maximum inhibition was also observed at the late G1 phase.
  2. 02LabIn vitro (cells)Mechanism

    In cultured rat aortic smooth muscle cells, VIP stimulated cAMP accumulation.

    In plain wordsIn cells from rat aorta, VIP raised cAMP levels inside the cells.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreasecAMP accumulation
    Study

    ratn: not reported in source

    cultured rat aortic smooth muscle cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    VIP also stimulated cAMP accumulation, and the accumulation by a combination of PACAP and VIP was not additive.
  3. 03LabIn vitro (cells)Mechanism

    In cultured rat aortic smooth muscle cells, VIP had little effect on phosphoinositide hydrolysis.

    In plain wordsIn cells from rat aorta, VIP had little effect on phosphoinositide breakdown.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changePhosphoinositide hydrolysis
    Study

    ratn: not reported in source

    cultured rat aortic smooth muscle cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both PACAP and VIP had little effect on phosphoinositide hydrolysis in these cells.

Studies that did not test the peptide alone2

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  1. 04LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Mechanism

    In cultured rat aortic smooth muscle cells, inhibition of DNA synthesis by a combination of PACAP and VIP was not additive.

    In plain wordsIn cells from rat aorta, PACAP and VIP together did not block DNA synthesis more than either alone.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeAVP-induced DNA synthesis with a combination of PACAP and VIP
    Study

    ratn: not reported in source

    cultured rat aortic smooth muscle cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    The patterns of both the dose-dependent inhibitions were similar, and the inhibition by a combination of PACAP and VIP was not additive.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  2. 05LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Mechanism

    In cultured rat aortic smooth muscle cells, suppression of DNA synthesis by PACAP or VIP was enhanced by the phosphodiesterase inhibitor IBMX.

    In plain wordsIn cells from rat aorta, the phosphodiesterase blocker IBMX made PACAP or VIP block DNA synthesis more strongly.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseSuppression of AVP-induced DNA synthesis with IBMX
    Study

    ratn: not reported in source

    cultured rat aortic smooth muscle cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    The suppression of the AVP-induced DNA synthesis by PACAP or VIP was enhanced by 3-isobutyl-1-methylxanthine, an inhibitor for phosphodiesterases.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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