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Study · Measured the body's own peptide · 1993

3 results

Substance P, calcitonin gene-related peptide, and vasoactive intestinal peptide increase in nasal secretions after allergen challenge in atopic patients.

Mosimann BL, White MV, Hohman RJ, Goldrich MS, Kaulbach HC, Kaliner MA

The Journal of allergy and clinical immunology1 Jul 1993Cited by 126 (Europe PMC)

PMID7687608 (opens in a new tab)DOI10.1016/0091-6749(93)90043-f (opens in a new tab)PepBankPUB-07687608
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelOther designOther

    In eight patients with allergic rhinitis, nasal VIP levels rose significantly above baseline after histamine challenge.

    In plain wordsIn eight patients with allergic rhinitis, the body's own VIP rose in nasal fluid after a histamine challenge.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP in nasal lavage after histamine challenge
    Study

    n = 8

    Comparator
    Baseline
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    whereas VIP did (p < 0.02).
    2 context sentences
    Summary · context
    Eight patients with allergic rhinitis were challenged nasally with 1 mg histamine or increasing doses of allergen.
    Summary · context
    Nasal lavages were collected into a cocktail of protease inhibitors in order to restrict neuropeptide degradation.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelOther designOther

    In eight patients with allergic rhinitis, nasal VIP levels rose significantly immediately after allergen challenge and returned to baseline within 2 hours.

    In plain wordsIn eight patients with allergic rhinitis, the body's own VIP rose in nasal fluid right after allergen exposure and returned to baseline within 2 hours.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP in nasal lavage immediately after allergen challenge
    Study

    n = 8

    Comparator
    Baseline
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    In contrast, SP, CGRP, and VIP all significantly increased immediately after allergen challenge and returned to baseline within 2 hours.
    2 context sentences
    Summary · context
    Eight patients with allergic rhinitis were challenged nasally with 1 mg histamine or increasing doses of allergen.
    Summary · context
    Nasal lavages were collected into a cocktail of protease inhibitors in order to restrict neuropeptide degradation.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelOther designOther

    In eight patients with allergic rhinitis, nasal VIP levels were not increased at the clinical peak of the late allergic reaction.

    In plain wordsIn eight patients with allergic rhinitis, the body's own VIP in nasal fluid did not rise during the late allergic reaction.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeVIP in nasal lavage at the late allergic reaction
    Study

    n = 8

    Comparator
    Baseline
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    At the clinical peak of the late allergic reaction, SP, but not CGRP or VIP, was increased slightly but significantly (p < 0.01).
    2 context sentences
    Summary · context
    Eight patients with allergic rhinitis were challenged nasally with 1 mg histamine or increasing doses of allergen.
    Summary · context
    Nasal lavages were collected into a cocktail of protease inhibitors in order to restrict neuropeptide degradation.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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