In corticosteroid-treated patients receiving calcitriol and calcium, lumbar bone changes were -0.2% per year with salmon calcitonin versus -1.3% without calcitonin.
In plain wordsIn corticosteroid-treated patients receiving calcitriol and calcium, lumbar bone loss was numerically smaller with calcitonin than without it.
- Peptide
- Calcitonin-salmon
- Outcome
- Direction not reportedFirst-year lumbar spine bone loss with versus without calcitonin
- Study
n: not reported in source
- Comparator
- Calcitriol plus calcium with placebo nasal spray
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- 400 IU per day · intranasal · 1 yearAs given in this study (human).
Measurements
- Lumbar spine bone density rate of change
- −0.2 % per year
- calcitriol plus calcitonin
- Lumbar spine bone density rate of change
- −1.3 % per year
- calcitriol without calcitonin
- Lumbar spine bone density rate of change
- −4.3 % per year
- calcium alone
Source sentences
Calcitriol (mean dose, 0.6 microgram per day), with or without calcitonin, prevented more bone loss from the lumbar spine (mean rates of change, -0.2 and -1.3 percent per year, respectively) than calcium alone (-4.3 percent per year, P = 0.0035).
1 context sentence(design, population, supporting numbers)
One hundred three patients starting long-term corticosteroid therapy were randomly assigned to receive 1000 mg of calcium per day orally and either calcitriol (0.5 to 1.0 microgram per day orally) plus salmon calcitonin (400 IU per day intranasally), calcitriol plus a placebo nasal spray, or double…