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Study · In vitro (cells) · 1993

2 results

Cytokines modulate the sensitivity of human fibroblasts to stimulation with insulin-like growth factor-I (IGF-I) by altering endogenous IGF-binding protein production.

Yateman ME, Claffey DC, Cwyfan Hughes SC, Frost VJ, Wass JA, Holly JM

The Journal of endocrinology1 Apr 1993Cited by 58 (Europe PMC)

PMID7684061 (opens in a new tab)DOI10.1677/joe.0.1370151 (opens in a new tab)PepBankPUB-07684061
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human dermal fibroblasts, Long-R3-IGF-I was approximately 20-fold more potent than IGF-I in stimulating growth in an MTT proliferation assay.

    In plain wordsIn cells, Long-R3-IGF-I stimulated fibroblast growth about 20 times more strongly than regular IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseFibroblast growth stimulation potency relative to IGF-I
    Study

    humann: not reported in source

    Human dermal fibroblasts
    Comparator
    IGF-I
    Outcome group
    Cell proliferation and differentiation · Skin and wound
    Studied dose
    Dose not stated

    Measurements

    Relative potency vs IGF-I
    ≈ 20 fold
    human dermal fibroblasts

    Source sentences

    Summary
    The IGF-I analogue Long-R3-IGF-I which has little affinity for the IGFBPs was approximately 20-fold more potent in this assay
    1 context sentence
    Summary · context
    Fibroblast proliferation was examined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric cytochemical bioassay.
  2. 02LabIn vitro (cells)Mechanism

    In human dermal fibroblasts, the growth-stimulating activity of Long-R3-IGF-I was unaffected by exogenous IGFBP-3.

    In plain wordsIn cells, adding IGFBP-3 did not change how well Long-R3-IGF-I stimulated fibroblast growth.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeEffect of exogenous IGFBP-3 on Long-R3-IGF-I activity
    Study

    humann: not reported in source

    Human dermal fibroblasts
    Outcome group
    Cell proliferation and differentiation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and was unaffected by exogenous IGFBP-3
    1 context sentence
    Summary · context
    Fibroblast proliferation was examined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric cytochemical bioassay.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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