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Study · In vitro (cells) · 1995

3 results

Neurokinin receptor antagonists inhibit the binding of growth hormone-releasing peptide to EP-1 human neuroblastoma cells.

Tai S, Kaji H, Okimura Y, Abe H, Chihara K

Biochemical and biophysical research communications1 Sept 1995Cited by 1 (Europe PMC)

PMID7677751 (opens in a new tab)DOI10.1006/bbrc.1995.2308 (opens in a new tab)PepBankPUB-07677751
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured human EP-1 neuroblastoma cells, KP-102 bound specifically, with a Kd comparable to that in rat pituitary and hypothalamus membranes.

    In plain wordsIn human nerve-cell-line cultures, KP-102 bound specifically to the cells, similar to its binding in rat brain tissue membranes.

    Peptide
    GHRP-2
    Outcome
    Not applicableSpecific binding of KP-102 to EP-1 cells
    Study

    humann: not reported in source

    EP-1 human neuroblastoma cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-102, a second generation growth hormone-releasing peptide, specifically bound to the human neuroblastoma cell line, EP-1, cultured in vitro
    2 context sentences
    Summary · context
    with a Kd value comparable to that in cell membranes of rat pituitary and hypothalamus.
    Summary · context
    KP-102, a second generation growth hormone-releasing peptide, specifically bound to the human neuroblastoma cell line, EP-1, cultured in vitro with a Kd value comparable to that in cell membranes of rat pituitary and hypothalamus.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured human EP-1 neuroblastoma cells, the KP-102-receptor complex had a molecular size of approximately 80 kDa.

    In plain wordsIn human nerve-cell-line cultures, the complex of KP-102 and its binding molecule measured about 80 kDa.

    Peptide
    GHRP-2
    Outcome
    Not applicableMolecular size of KP-102-receptor complex
    Study

    humann: not reported in source

    EP-1 human neuroblastoma cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Molecular size of KP-102-receptor complex
    ≈ 80 kDa
    EP-1 cells

    Source sentences

    Summary
    By crosslinking study, the molecular size of the KP-102-receptor complex was found to be approximately 80kDa.
    1 context sentence
    Summary · context
    KP-102, a second generation growth hormone-releasing peptide, specifically bound to the human neuroblastoma cell line, EP-1, cultured in vitro with a Kd value comparable to that in cell membranes of rat pituitary and hypothalamus.
  3. 03LabIn vitro (cells)Activity measurement

    In cultured human EP-1 cells, a substance P analogue and nonpeptidyl neurokinin receptor antagonists competed with KP-102 for binding, but substance P and substance K did not.

    In plain wordsIn human nerve-cell-line cultures, some neurokinin receptor blockers competed with KP-102 for binding, but substance P and substance K did not.

    Peptide
    GHRP-2
    Outcome
    Not applicableCompetition of neurokinin receptor ligands with KP-102 binding
    Study

    humann: not reported in source

    EP-1 human neuroblastoma cells
    Comparator
    Substance P analogue and neurokinin receptor antagonists
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Substance P analogue, as well as nonpeptidyl antagonists of the neurokinin receptor, competed with KP-102 in its binding to EP-1 cells, although neither substance P nor substance K affected the binding.
    1 context sentence
    Summary · context
    KP-102, a second generation growth hormone-releasing peptide, specifically bound to the human neuroblastoma cell line, EP-1, cultured in vitro with a Kd value comparable to that in cell membranes of rat pituitary and hypothalamus.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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