The anabolic effect of human PTH (1-34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate--is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system?

Delmas PD, Vergnaud P, Arlot ME, Pastoureau P, Meunier PJ, Nilssen MH

Bone1 Jun 1995Cited by 111 (Europe PMC)

PMID7669436DOI10.1016/8756-3282(95)00113-rPepBankPUB-07669436

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In old female sheep, PTH(1-34) significantly increased urinary pyridinoline.
In plain wordsIn sheep, PTH increased urinary pyridinoline, a bone breakdown marker.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseUrinary pyridinoline
Study
sheepn: not reported in source
Old female sheep
Outcome group
Bone and joint · Musculoskeletal
Studied dose
500 IU/d · 3 monthsAs given in this study (sheep).
Source sentences
Summary
As expected, PTH (1-34) induced a significant increase of urinary pyridinoline and hydroxyproline (reflecting bone resorption), and of serum osteocalcin and alkaline phosphatase (reflecting bone formation), that were consistent with an increase of resorption and tetracycline-based formation of bone…
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed the effects of PTH (1-34) (500 IU/d) with or without the bisphosphonate tiludronate (1 mg/kg per day) for 3 months on biochemical and histological indices of bone turnover in old female sheep, an animal model which has a slow bone remodeling activity that resembles the one of elderly women.
Report a problemFND-0766943601
02AnimalAnimal study (in vivo)Efficacy outcome
In old female sheep, PTH(1-34) significantly increased urinary hydroxyproline.
In plain wordsIn sheep, PTH increased urinary hydroxyproline, a bone breakdown marker.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseUrinary hydroxyproline
Study
sheepn: not reported in source
Old female sheep
Outcome group
Bone and joint · Musculoskeletal
Studied dose
500 IU/d · 3 monthsAs given in this study (sheep).
Source sentences
Summary
As expected, PTH (1-34) induced a significant increase of urinary pyridinoline and hydroxyproline (reflecting bone resorption), and of serum osteocalcin and alkaline phosphatase (reflecting bone formation), that were consistent with an increase of resorption and tetracycline-based formation of bone…
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed the effects of PTH (1-34) (500 IU/d) with or without the bisphosphonate tiludronate (1 mg/kg per day) for 3 months on biochemical and histological indices of bone turnover in old female sheep, an animal model which has a slow bone remodeling activity that resembles the one of elderly women.
Report a problemFND-0766943602
03AnimalAnimal study (in vivo)Efficacy outcome
In old female sheep, PTH(1-34) significantly increased serum osteocalcin.
In plain wordsIn sheep, PTH increased serum osteocalcin, a bone formation marker.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum osteocalcin
Study
sheepn: not reported in source
Old female sheep
Outcome group
Bone and joint · Musculoskeletal
Studied dose
500 IU/d · 3 monthsAs given in this study (sheep).
Source sentences
Summary
As expected, PTH (1-34) induced a significant increase of urinary pyridinoline and hydroxyproline (reflecting bone resorption), and of serum osteocalcin and alkaline phosphatase (reflecting bone formation), that were consistent with an increase of resorption and tetracycline-based formation of bone…
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed the effects of PTH (1-34) (500 IU/d) with or without the bisphosphonate tiludronate (1 mg/kg per day) for 3 months on biochemical and histological indices of bone turnover in old female sheep, an animal model which has a slow bone remodeling activity that resembles the one of elderly women.
Report a problemFND-0766943603
04AnimalAnimal study (in vivo)Efficacy outcome
In old female sheep, PTH(1-34) significantly increased serum alkaline phosphatase.
In plain wordsIn sheep, PTH increased serum alkaline phosphatase, a bone formation marker.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum alkaline phosphatase
Study
sheepn: not reported in source
Old female sheep
Outcome group
Bone and joint · Musculoskeletal
Studied dose
500 IU/d · 3 monthsAs given in this study (sheep).
Source sentences
Summary
As expected, PTH (1-34) induced a significant increase of urinary pyridinoline and hydroxyproline (reflecting bone resorption), and of serum osteocalcin and alkaline phosphatase (reflecting bone formation), that were consistent with an increase of resorption and tetracycline-based formation of bone…
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed the effects of PTH (1-34) (500 IU/d) with or without the bisphosphonate tiludronate (1 mg/kg per day) for 3 months on biochemical and histological indices of bone turnover in old female sheep, an animal model which has a slow bone remodeling activity that resembles the one of elderly women.
Report a problemFND-0766943604
05AnimalAnimal study (in vivo)Efficacy outcome
In old female sheep, PTH(1-34) increased bone resorption on iliac crest biopsy.
In plain wordsIn sheep, PTH increased bone breakdown measured by biopsy.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseHistological bone resorption
Study
sheepn: not reported in source
Old female sheep
Outcome group
Bone and joint · Musculoskeletal
Studied dose
500 IU/d · 3 monthsAs given in this study (sheep).
Source sentences
Summary
As expected, PTH (1-34) induced a significant increase of urinary pyridinoline and hydroxyproline (reflecting bone resorption), and of serum osteocalcin and alkaline phosphatase (reflecting bone formation), that were consistent with an increase of resorption and tetracycline-based formation of bone…
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed the effects of PTH (1-34) (500 IU/d) with or without the bisphosphonate tiludronate (1 mg/kg per day) for 3 months on biochemical and histological indices of bone turnover in old female sheep, an animal model which has a slow bone remodeling activity that resembles the one of elderly women.
Report a problemFND-0766943605
06AnimalAnimal study (in vivo)Efficacy outcome
In old female sheep, PTH(1-34) increased tetracycline-based bone formation on iliac crest biopsy.
In plain wordsIn sheep, PTH increased bone formation measured by biopsy.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTetracycline-based bone formation
Study
sheepn: not reported in source
Old female sheep
Outcome group
Bone and joint · Musculoskeletal
Studied dose
500 IU/d · 3 monthsAs given in this study (sheep).
Source sentences
Summary
As expected, PTH (1-34) induced a significant increase of urinary pyridinoline and hydroxyproline (reflecting bone resorption), and of serum osteocalcin and alkaline phosphatase (reflecting bone formation), that were consistent with an increase of resorption and tetracycline-based formation of bone…
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed the effects of PTH (1-34) (500 IU/d) with or without the bisphosphonate tiludronate (1 mg/kg per day) for 3 months on biochemical and histological indices of bone turnover in old female sheep, an animal model which has a slow bone remodeling activity that resembles the one of elderly women.
Report a problemFND-0766943606

Studies that did not test the peptide alone1

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In old female sheep, PTH plus tiludronate did not change biochemical or histological turnover indices versus control groups.
In plain wordsIn sheep, PTH plus tiludronate did not change bone turnover indices versus control groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeCombined therapy bone turnover indices
Study
sheepn: not reported in source
Old female sheep
Comparator
Control groups
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Surprisingly, in the combined therapy group, biochemical and histological indices of both resorption and formation did not differ from the control groups.
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed the effects of PTH (1-34) (500 IU/d) with or without the bisphosphonate tiludronate (1 mg/kg per day) for 3 months on biochemical and histological indices of bone turnover in old female sheep, an animal model which has a slow bone remodeling activity that resembles the one of elderly women.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-0766943607

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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