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Study · Animal study (in vivo) · guinea pig · 1995

7 results

[The efficacy of using thymogen in an experimental infection caused by Yersinia enterocolitica].

Iushchuk ND, Tseneva GIa, Alenushkina TV, Kuliashova LB

Zhurnal mikrobiologii, epidemiologii i immunobiologii1 May 1995

PMID7660690 (opens in a new tab)PepBankPUB-07660690
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In infected guinea pigs, thymogen decreased the polyclonal immune response.

    In plain wordsIn guinea pigs with infection, thymogen reduced the polyclonal immune response.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreasePolyclonal immune response
    Study

    guinea pign: not reported in source

    Yersinia enterocolitica infection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 micrograms/kg daily · injection · 4 daysAs given in this study (guinea pig).

    Source sentences

    Summary
    it decreased their polyclonal immune response, the development of autoimmune reactions
    2 context sentences
    Summary · context
    The effect of thymogen of the course of the infectious process caused by Y.enterocolitica serovars O3 and O9 in guinea pigs was studied.
    Summary · context
    Thymogen was introduced into the animals on day 2 after their infection with Y.enterocolitica O3 and O9, introduced in daily injections of 10 micrograms/kg of body weight for 4 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In infected guinea pigs, thymogen decreased the development of autoimmune reactions.

    In plain wordsIn guinea pigs with infection, thymogen reduced the development of autoimmune reactions.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseAutoimmune reactions
    Study

    guinea pign: not reported in source

    Yersinia enterocolitica infection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 micrograms/kg daily · injection · 4 daysAs given in this study (guinea pig).

    Source sentences

    Summary
    it decreased their polyclonal immune response, the development of autoimmune reactions
    2 context sentences
    Summary · context
    The effect of thymogen of the course of the infectious process caused by Y.enterocolitica serovars O3 and O9 in guinea pigs was studied.
    Summary · context
    Thymogen was introduced into the animals on day 2 after their infection with Y.enterocolitica O3 and O9, introduced in daily injections of 10 micrograms/kg of body weight for 4 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In guinea pigs infected enterally with Y. enterocolitica O9, thymogen promoted delayed hypersensitivity development.

    In plain wordsIn guinea pigs with enteral Y. enterocolitica O9 infection, thymogen promoted delayed hypersensitivity.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseDelayed hypersensitivity in O9 infection
    Study

    guinea pign: not reported in source

    Yersinia enterocolitica O9 enteral infection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 micrograms/kg daily · injection · 4 daysAs given in this study (guinea pig).

    Source sentences

    Summary
    and promoted the intensive development of delayed hypersensitivity (DH) after their enteral infection with Y.enterocolitica O9
    2 context sentences
    Summary · context
    The effect of thymogen of the course of the infectious process caused by Y.enterocolitica serovars O3 and O9 in guinea pigs was studied.
    Summary · context
    Thymogen was introduced into the animals on day 2 after their infection with Y.enterocolitica O3 and O9, introduced in daily injections of 10 micrograms/kg of body weight for 4 days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In guinea pigs infected with Y. enterocolitica O3, thymogen did not affect delayed hypersensitivity development.

    In plain wordsIn guinea pigs with Y. enterocolitica O3 infection, thymogen did not affect delayed hypersensitivity development.

    Peptide
    Thymogen (oglufanide)
    Outcome
    No significant changeDelayed hypersensitivity in O3 infection
    Study

    guinea pign: not reported in source

    Yersinia enterocolitica O3 infection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 micrograms/kg daily · injection · 4 daysAs given in this study (guinea pig).

    Source sentences

    Summary
    and had no effect on the development of DH in the animals infected with Y.enterocolitica O3
    2 context sentences
    Summary · context
    The effect of thymogen of the course of the infectious process caused by Y.enterocolitica serovars O3 and O9 in guinea pigs was studied.
    Summary · context
    Thymogen was introduced into the animals on day 2 after their infection with Y.enterocolitica O3 and O9, introduced in daily injections of 10 micrograms/kg of body weight for 4 days.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In infected guinea pigs, thymogen enhanced nonspecific resistance.

    In plain wordsIn guinea pigs with infection, thymogen increased nonspecific resistance.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseNonspecific resistance
    Study

    guinea pign: not reported in source

    Yersinia enterocolitica infection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 micrograms/kg daily · injection · 4 daysAs given in this study (guinea pig).

    Source sentences

    Summary
    it also enhanced the nonspecific resistance of the body,
    2 context sentences
    Summary · context
    The effect of thymogen of the course of the infectious process caused by Y.enterocolitica serovars O3 and O9 in guinea pigs was studied.
    Summary · context
    Thymogen was introduced into the animals on day 2 after their infection with Y.enterocolitica O3 and O9, introduced in daily injections of 10 micrograms/kg of body weight for 4 days.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In infected guinea pigs, thymogen decreased infective agent dissemination in organs and tissues.

    In plain wordsIn guinea pigs with infection, thymogen reduced the spread of infective agents through organs and tissues.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseInfective agent dissemination
    Study

    guinea pign: not reported in source

    Yersinia enterocolitica infection
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    10 micrograms/kg daily · injection · 4 daysAs given in this study (guinea pig).

    Source sentences

    Summary
    it also enhanced the nonspecific resistance of the body, thus leading to a decrease in the dissemination of the infective agents in different organs and tissues and to their subsequent elimination from the body.
    2 context sentences
    Summary · context
    The effect of thymogen of the course of the infectious process caused by Y.enterocolitica serovars O3 and O9 in guinea pigs was studied.
    Summary · context
    Thymogen was introduced into the animals on day 2 after their infection with Y.enterocolitica O3 and O9, introduced in daily injections of 10 micrograms/kg of body weight for 4 days.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In infected guinea pigs, thymogen promoted subsequent elimination of infective agents from the body.

    In plain wordsIn guinea pigs with infection, thymogen promoted subsequent elimination of infective agents.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseInfective agent elimination
    Study

    guinea pign: not reported in source

    Yersinia enterocolitica infection
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    10 micrograms/kg daily · injection · 4 daysAs given in this study (guinea pig).

    Source sentences

    Summary
    it also enhanced the nonspecific resistance of the body, thus leading to a decrease in the dissemination of the infective agents in different organs and tissues and to their subsequent elimination from the body.
    2 context sentences
    Summary · context
    The effect of thymogen of the course of the infectious process caused by Y.enterocolitica serovars O3 and O9 in guinea pigs was studied.
    Summary · context
    Thymogen was introduced into the animals on day 2 after their infection with Y.enterocolitica O3 and O9, introduced in daily injections of 10 micrograms/kg of body weight for 4 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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