Search for the structures initiating seizures triggered by intraventricular injection of the mu opioid agonist dermorphin in rats.

Gioanni Y, Greco B, Prevost J

Epilepsia1 Sept 1995Cited by 3 (Europe PMC)

PMID7649132DOI10.1111/j.1528-1157.1995.tb01636.xPepBankPUB-07649132

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Safety outcome
In free-moving rats, intravenous dermorphin did not induce epileptiform activity.
In plain wordsIn rats, intravenous dermorphin did not induce seizure-like electrical activity.
Peptide
Dermorphin
Outcome
No significant changeIntravenous epileptiform activity
Study
ratn: not reported in source
Free-moving rats
Outcome group
Adverse events · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
The intravenous injections of DRM did not induce epileptiform activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Free-moving rats received intraventricular (i.c.v.) or intravenous (i.v.) injections of the mu opioid agonist dermorphin (DRM).
Report a problemFND-0764913201
02AnimalAnimal study (in vivo)Safety outcome
In free-moving rats, intracerebroventricular dermorphin triggered several types of electrical seizures.
In plain wordsIn rats, dermorphin injected into a brain ventricle triggered electrical seizures.
Peptide
Dermorphin
Outcome
IncreaseElectrical seizures
Study
ratn: not reported in source
Free-moving rats
Outcome group
Adverse events · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The intracerebroventricular injections of DRM triggered several types of electrical seizures and interictal spikes.
1 context sentence(design, population, supporting numbers)
Summary · context
Free-moving rats received intraventricular (i.c.v.) or intravenous (i.v.) injections of the mu opioid agonist dermorphin (DRM).
Report a problemFND-0764913202
03AnimalAnimal study (in vivo)Safety outcome
In free-moving rats, intracerebroventricular dermorphin triggered interictal spikes.
In plain wordsIn rats, dermorphin injected into a brain ventricle triggered electrical spikes between seizures.
Peptide
Dermorphin
Outcome
IncreaseInterictal spikes
Study
ratn: not reported in source
Free-moving rats
Outcome group
Adverse events · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The intracerebroventricular injections of DRM triggered several types of electrical seizures and interictal spikes.
1 context sentence(design, population, supporting numbers)
Summary · context
Free-moving rats received intraventricular (i.c.v.) or intravenous (i.v.) injections of the mu opioid agonist dermorphin (DRM).
Report a problemFND-0764913203
04AnimalAnimal study (in vivo)Mechanism
In rats given dermorphin, generalized epileptiform discharges appeared first in ventral hippocampal CA3, followed immediately by CA1, entorhinal cortex and amygdala.
In plain wordsIn rats, dermorphin-related electrical discharges appeared first in ventral hippocampal CA3 and immediately involved other brain regions.
Peptide
Dermorphin
Outcome
Not applicableOrigin and spread of epileptiform discharges
Study
ratn: not reported in source
Free-moving rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Epileptiform discharges, at once generalized, appeared first in the CA3 area of the ventral hippocampus, with involvement of the CA1 area of ventral hippocampus, the entorhinal cortex and the amygdala following immediately.
1 context sentence(design, population, supporting numbers)
Summary · context
Free-moving rats received intraventricular (i.c.v.) or intravenous (i.v.) injections of the mu opioid agonist dermorphin (DRM).
Report a problemFND-0764913204

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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