Skip to content

Study · Animal study (in vivo) · rat · 1995

2 results

Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion.

Buerke M, Murohara T, Skurk C, Nuss C, Tomaselli K, Lefer AM

Proceedings of the National Academy of Sciences of the United States of America1 Aug 1995Cited by 269 (Europe PMC)

PMID7644533 (opens in a new tab)PMCIDPMC41280 (opens in a new tab)DOI10.1073/pnas.92.17.8031 (opens in a new tab)PepBankPUB-07644533
Source linkPubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In myocardial ischemia reperfusion, des-(1-3)-IGF-I did not show the myocardial injury protection observed with IGF-I.

    In plain wordsIn rats, des-(1-3)-IGF-I did not show the heart injury protection seen with IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeMyocardial injury protection
    Study

    ratn: not reported in source

    Myocardial ischemia reperfusion
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This protective effect of IGF-I was not observed with des-(1-3)-IGF-I.
    2 context sentences
    Summary · context
    IGF-I (1-10 micrograms per rat) administered 1 hr prior to ischemia significantly attenuated myocardial injury (i.e., creatine kinase loss) compared to vehicle (P < 0.001).
    Summary · context
    In the present study, the cardioprotective effects of insulin-like growth factor I (IGF-I) were examined in a murine model of myocardial ischemia reperfusion (i.e., 20 min + 24 hr).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In myocardial ischemia reperfusion, des-(1-3)-IGF-I did not show the protective attenuation of cardiac myeloperoxidase activity reported for IGF-I.

    In plain wordsIn rats, des-(1-3)-IGF-I did not show the reduction in cardiac myeloperoxidase activity reported for IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeCardiac myeloperoxidase attenuation
    Study

    ratn: not reported in source

    Myocardial ischemia reperfusion
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This protective effect of IGF-I was not observed with des-(1-3)-IGF-I.
    2 context sentences
    Summary · context
    In addition, cardiac myeloperoxidase activity, an index of neutrophil accumulation, in the ischemic area was significantly attenuated by IGF-I (P < 0.001).
    Summary · context
    In the present study, the cardioprotective effects of insulin-like growth factor I (IGF-I) were examined in a murine model of myocardial ischemia reperfusion (i.e., 20 min + 24 hr).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.