Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat.

Haanwinckel MA, Elias LK, Favaretto AL, Gutkowska J, McCann SM, Antunes-Rodrigues J

Proceedings of the National Academy of Sciences of the United States of America1 Aug 1995Cited by 145 (Europe PMC)

PMID7644511PMCIDPMC41254DOI10.1073/pnas.92.17.7902PepBankPUB-07644511

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, intraperitoneal oxytocin caused dose-dependent increases in urinary osmolality, sodium excretion and potassium excretion.
In plain wordsIn rats, oxytocin injected into the belly increased urine concentration and the loss of sodium and potassium in urine, with higher doses giving larger effects.
Peptide
Oxytocin
Outcome
IncreaseUrinary osmolality, natriuresis and kaliuresis
Study
ratn: not reported in source
Outcome group
Electrolyte balance · Kidney and urinary
Studied dose
1-10 nmol · intraperitonealAs given in this study (rat).
Source sentences
Summary
Oxytocin (1-10 nmol) injected i.p. caused significant, dose-dependent increases in urinary osmolality, natriuresis, and kaliuresis.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present research we investigated the possible role of oxytocin, one of the two principal neurohypophysial hormones, in the mediation of ANP release.
Report a problemFND-0764451101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, intraperitoneal oxytocin also produced a delayed antidiuretic effect.
In plain wordsIn rats, oxytocin injected into the belly also reduced urine output after a delay.
Peptide
Oxytocin
Outcome
DecreaseDelayed antidiuretic effect
Study
ratn: not reported in source
Outcome group
Electrolyte balance · Kidney and urinary
Studied dose
1-10 nmol · intraperitonealAs given in this study (rat).
Source sentences
Summary
A delayed antidiuretic effect was also observed.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present research we investigated the possible role of oxytocin, one of the two principal neurohypophysial hormones, in the mediation of ANP release.
Report a problemFND-0764451102
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, intraperitoneal oxytocin increased plasma atrial natriuretic peptide nearly 4-fold at 20 min, with no change in control rats.
In plain wordsIn rats, oxytocin injected into the belly raised blood levels of the heart hormone ANP, while control rats showed no change.
Peptide
Oxytocin
Outcome
IncreasePlasma ANP after intraperitoneal oxytocin
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Cardiovascular
Studied dose
10 nmol · intraperitonealAs given in this study (rat).
Measurements
Plasma ANP increase
≈ 4 fold
oxytocin 10 nmol i.p., 20 min
Source sentences
Summary
Plasma ANP concentrations increased nearly 4-fold (P < 0.01) 20 min after i.p. oxytocin (10 nmol), but there was no change in plasma ANP values in control rats.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present research we investigated the possible role of oxytocin, one of the two principal neurohypophysial hormones, in the mediation of ANP release.
Report a problemFND-0764451103
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, intravenous oxytocin induced a dose-related increase in plasma ANP at 5 min.
In plain wordsIn rats, oxytocin given into a vein raised blood levels of the heart hormone ANP, with larger doses giving larger rises.
Peptide
Oxytocin
Outcome
IncreasePlasma ANP after intravenous oxytocin
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Cardiovascular
Studied dose
1 or 10 nmol · intravenousAs given in this study (rat).
Source sentences
Summary
When oxytocin (1 or 10 nmol) was injected i.v., it also induced a dose-related increase in plasma ANP at 5 min (P < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present research we investigated the possible role of oxytocin, one of the two principal neurohypophysial hormones, in the mediation of ANP release.
Report a problemFND-0764451104

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

05AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, blood volume expansion with isotonic saline rapidly increased plasma oxytocin.
In plain wordsIn rats, adding fluid to the blood quickly raised the body's own oxytocin level.
Peptide
Oxytocin
Outcome
IncreasePlasma oxytocin after isotonic blood volume expansion
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
BVE by intra-atrial injection of isotonic saline induced a rapid (5 min postinjection) increase in plasma oxytocin and ANP concentrations
1 context sentence(design, population, supporting numbers)
Summary · context
In the present research we investigated the possible role of oxytocin, one of the two principal neurohypophysial hormones, in the mediation of ANP release.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0764451105
06AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, hypertonic volume expansion produced similar results, including a rise in plasma oxytocin.
In plain wordsIn rats, adding salty fluid to the blood gave a similar rise in the body's own oxytocin.
Peptide
Oxytocin
Outcome
IncreasePlasma oxytocin after hypertonic volume expansion
Study
ratn: not reported in source
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
BVE by intra-atrial injection of isotonic saline induced a rapid (5 min postinjection) increase in plasma oxytocin and ANP concentrations and a concomitant decrease in plasma arginine vasopressin concentration. Results were similar with hypertonic volume expansion, except that this induced a transie…
1 context sentence(design, population, supporting numbers)
Summary · context
In the present research we investigated the possible role of oxytocin, one of the two principal neurohypophysial hormones, in the mediation of ANP release.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0764451106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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