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Study · Randomized controlled trial · 1995

6 results

Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man.

Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, Steiger A

Neuroendocrinology1 May 1995Cited by 55 (Europe PMC)

PMID7617137 (opens in a new tab)DOI10.1159/000126883 (opens in a new tab)PepBankPUB-07617137
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In normal men, repeated intravenous GHRP boluses raised night-time GH concentration versus placebo.

    In plain wordsIn healthy men, GHRP‑6 raised night-time growth hormone more than placebo.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH concentration (22.00 to 03.00 h)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    4 x 50 micrograms · intravenousAs given in this study (human).

    Measurements

    GH concentration
    15.4 ng/ml
    after GHRP
    GH concentration
    5.5 ng/ml
    after placebo

    Source sentences

    Summary
    After GHRP, the GH concentration (22.00 to 03.00 h) increased (15.4 +/- 9.6 ng/ml after GHRP vs. 5.5 +/- 4.0 ng/ml after PL, p < 0.02), as did the ACTH level (22.00 to 02.00 h: 21.0 +/- 5.3 pg/ml after GHRP vs. 16.6 +/- 3.1 pg/ml after PL, p < 0.02).
    1 context sentence
    Summary · context
    We compared the effect of repetitive i.v. boluses (4 x 50 micrograms) of GHRP and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of GH, ACTH and cortisol (20.00 to 07.00 h) in normal male controls.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In normal men, repeated intravenous GHRP boluses raised the ACTH level versus placebo.

    In plain wordsIn healthy men, GHRP‑6 raised the stress hormone ACTH more than placebo.

    Peptide
    GHRP-6
    Outcome
    IncreaseACTH level (22.00 to 02.00 h)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    4 x 50 micrograms · intravenousAs given in this study (human).

    Measurements

    ACTH level
    21 pg/ml
    after GHRP
    ACTH level
    16.6 pg/ml
    after placebo

    Source sentences

    Summary
    After GHRP, the GH concentration (22.00 to 03.00 h) increased (15.4 +/- 9.6 ng/ml after GHRP vs. 5.5 +/- 4.0 ng/ml after PL, p < 0.02), as did the ACTH level (22.00 to 02.00 h: 21.0 +/- 5.3 pg/ml after GHRP vs. 16.6 +/- 3.1 pg/ml after PL, p < 0.02).
    1 context sentence
    Summary · context
    We compared the effect of repetitive i.v. boluses (4 x 50 micrograms) of GHRP and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of GH, ACTH and cortisol (20.00 to 07.00 h) in normal male controls.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In normal men, repeated intravenous GHRP boluses enhanced night-time cortisol secretion versus placebo.

    In plain wordsIn healthy men, GHRP‑6 raised night-time cortisol more than placebo.

    Peptide
    GHRP-6
    Outcome
    IncreaseCortisol secretion (22.00 to 03.00 h)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    4 x 50 micrograms · intravenousAs given in this study (human).

    Measurements

    Cortisol
    56 ng/ml
    after GHRP
    Cortisol
    25.2 ng/ml
    after placebo

    Source sentences

    Summary
    During the total night, and particularly during the first half of the night, cortisol secretion was enhanced (22.00 to 03.00 h: 56.0 +/- 31.0 ng/ml after GHRP vs. 25.2 +/- 9.0 ng/ml after PL, p < 0.02).
    1 context sentence
    Summary · context
    We compared the effect of repetitive i.v. boluses (4 x 50 micrograms) of GHRP and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of GH, ACTH and cortisol (20.00 to 07.00 h) in normal male controls.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In normal men, repeated intravenous GHRP boluses increased stage 2 sleep versus placebo.

    In plain wordsIn healthy men, GHRP‑6 increased the time in stage 2 sleep compared with placebo.

    Peptide
    GHRP-6
    Outcome
    IncreaseStage 2 sleep duration
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    4 x 50 micrograms · intravenousAs given in this study (human).

    Measurements

    Stage 2 sleep
    270.1 min
    after GHRP
    Stage 2 sleep
    245.4 min
    after placebo

    Source sentences

    Summary
    Stage 2 sleep increased (270.1 +/- 25.3 min after GHRP vs. 245.4 +/- 25.8 min after PL, p < 0.02)
    1 context sentence
    Summary · context
    We compared the effect of repetitive i.v. boluses (4 x 50 micrograms) of GHRP and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of GH, ACTH and cortisol (20.00 to 07.00 h) in normal male controls.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In normal men, repeated intravenous GHRP boluses did not change slow-wave sleep versus placebo.

    In plain wordsIn healthy men, GHRP‑6 did not change deep slow-wave sleep compared with placebo.

    Peptide
    GHRP-6
    Outcome
    No significant changeSlow-wave sleep
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    4 x 50 micrograms · intravenousAs given in this study (human).

    Source sentences

    Summary
    whereas other sleep-EEG variables including SWS remained unchanged.
    1 context sentence
    Summary · context
    We compared the effect of repetitive i.v. boluses (4 x 50 micrograms) of GHRP and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of GH, ACTH and cortisol (20.00 to 07.00 h) in normal male controls.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In normal men, repeated intravenous GHRP boluses did not change other sleep-EEG variables versus placebo.

    In plain wordsIn healthy men, GHRP‑6 did not change other sleep recording measures compared with placebo.

    Peptide
    GHRP-6
    Outcome
    No significant changeOther sleep-EEG variables
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    4 x 50 micrograms · intravenousAs given in this study (human).

    Source sentences

    Summary
    whereas other sleep-EEG variables including SWS remained unchanged.
    1 context sentence
    Summary · context
    We compared the effect of repetitive i.v. boluses (4 x 50 micrograms) of GHRP and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of GH, ACTH and cortisol (20.00 to 07.00 h) in normal male controls.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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