Randomized double-blind placebo-controlled trial of early octreotide in patients with postoperative enterocutaneous fistula.

Sancho JJ, di Costanzo J, Nubiola P, Larrad A, Beguiristain A, Roqueta F, Franch G, Oliva A, Gubern JM, Sitges-Serra A

The British journal of surgery1 May 1995Cited by 68 (Europe PMC)

PMID7613936DOI10.1002/bjs.1800820521PepBankPUB-07613936

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialEfficacy outcome
In patients with postoperative fistulas, output reduction at 24 h was similar with octreotide and placebo: 66(43) versus 68(47) per cent (P = 0.9).
In plain wordsIn patients with postoperative fistulas, octreotide and placebo produced similar output reductions at 24 h.
Peptide
Octreotide
Outcome
No significant changeFistula output reduction at 24 h
Study
n = 31
Comparator
Parenteral nutrition plus placebo
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
100 micrograms every 8 h · subcutaneousAs given in this study (human).
Measurements
Reduction in fistula output at 24 h
66%
octreotide plus parenteral nutrition; SD 43
Reduction in fistula output at 24 h
68%
placebo plus parenteral nutrition; SD 47
Source sentences
Summary
Mean(s.d.) reduction in output was similar after octreotide and placebo at 24 h (66(43) versus 68(47) per cent, P = 0.9), 48 h (60(46) versus 57(43) per cent, P = 0.8) and 72 h (62(50) versus 66(49) per cent, P = 0.9) after starting the combined treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The present trial was undertaken to test whether early combined treatment with parenteral nutrition and octreotide 100 micrograms every 8 h by subcutaneous injection had a beneficial effect compared with parenteral nutrition plus placebo.
Summary · context
Thirty-one patients with post-operative gastrointestinal or pancreatic fistula were randomly assigned to receive parenteral nutrition plus octreotide (14 patients) or placebo (17) within 8 days of fistula onset.
Report a problemFND-0761393601
02HumanRandomized controlled trialEfficacy outcome
In patients with postoperative fistulas, output reduction at 48 h was similar with octreotide and placebo: 60(46) versus 57(43) per cent (P = 0.8).
In plain wordsIn patients with postoperative fistulas, octreotide and placebo produced similar output reductions at 48 h.
Peptide
Octreotide
Outcome
No significant changeFistula output reduction at 48 h
Study
n = 31
Comparator
Parenteral nutrition plus placebo
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
100 micrograms every 8 h · subcutaneousAs given in this study (human).
Measurements
Reduction in fistula output at 48 h
60%
octreotide plus parenteral nutrition; SD 46
Reduction in fistula output at 48 h
57%
placebo plus parenteral nutrition; SD 43
Source sentences
Summary
Mean(s.d.) reduction in output was similar after octreotide and placebo at 24 h (66(43) versus 68(47) per cent, P = 0.9), 48 h (60(46) versus 57(43) per cent, P = 0.8) and 72 h (62(50) versus 66(49) per cent, P = 0.9) after starting the combined treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The present trial was undertaken to test whether early combined treatment with parenteral nutrition and octreotide 100 micrograms every 8 h by subcutaneous injection had a beneficial effect compared with parenteral nutrition plus placebo.
Summary · context
Thirty-one patients with post-operative gastrointestinal or pancreatic fistula were randomly assigned to receive parenteral nutrition plus octreotide (14 patients) or placebo (17) within 8 days of fistula onset.
Report a problemFND-0761393602
03HumanRandomized controlled trialEfficacy outcome
In patients with postoperative fistulas, output reduction at 72 h was similar with octreotide and placebo: 62(50) versus 66(49) per cent (P = 0.9).
In plain wordsIn patients with postoperative fistulas, octreotide and placebo produced similar output reductions at 72 hours.
Peptide
Octreotide
Outcome
No significant changeFistula output reduction at 72 h
Study
n = 31
Comparator
Parenteral nutrition plus placebo
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
100 micrograms every 8 h · subcutaneousAs given in this study (human).
Measurements
Output reduction at 72 h
62 per cent
octreotide plus parenteral nutrition
SD of output reduction at 72 h
50 per cent
octreotide plus parenteral nutrition
Output reduction at 72 h
66 per cent
placebo plus parenteral nutrition
SD of output reduction at 72 h
49 per cent
placebo plus parenteral nutrition
P value
0.9
72 h
Source sentences
Summary
Mean(s.d.) reduction in output was similar after octreotide and placebo at 24 h (66(43) versus 68(47) per cent, P = 0.9), 48 h (60(46) versus 57(43) per cent, P = 0.8) and 72 h (62(50) versus 66(49) per cent, P = 0.9) after starting the combined treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The present trial was undertaken to test whether early combined treatment with parenteral nutrition and octreotide 100 micrograms every 8 h by subcutaneous injection had a beneficial effect compared with parenteral nutrition plus placebo.
Summary · context
Thirty-one patients with post-operative gastrointestinal or pancreatic fistula were randomly assigned to receive parenteral nutrition plus octreotide (14 patients) or placebo (17) within 8 days of fistula onset.
Report a problemFND-0761393603
04HumanRandomized controlled trialEfficacy outcome
In patients with postoperative fistulas, closure within 20 days occurred in eight of 14 with octreotide versus six of 17 with placebo (P = 0.4).
In plain wordsIn patients with postoperative fistulas, closure was numerically higher with octreotide than placebo, without statistical significance.
Peptide
Octreotide
Outcome
IncreaseSpontaneous fistula closure within 20 days
Study
n = 31
Comparator
Parenteral nutrition plus placebo
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
100 micrograms every 8 h · subcutaneousAs given in this study (human).
Measurements
Fistulas closed within 20 days
8 of 14 fistulas
octreotide plus parenteral nutrition
Fistulas closed within 20 days
6 of 17 fistulas
placebo plus parenteral nutrition
P value
0.4
closure within 20 days
Source sentences
Summary
Closure within 20 days was observed in eight of 14 fistulas in patients given octreotide and in six of 17 in those receiving placebo (P = 0.4).
2 context sentences(design, population, supporting numbers)
Summary · context
The present trial was undertaken to test whether early combined treatment with parenteral nutrition and octreotide 100 micrograms every 8 h by subcutaneous injection had a beneficial effect compared with parenteral nutrition plus placebo.
Summary · context
Thirty-one patients with post-operative gastrointestinal or pancreatic fistula were randomly assigned to receive parenteral nutrition plus octreotide (14 patients) or placebo (17) within 8 days of fistula onset.
Report a problemFND-0761393604

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

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