In cortical slices from young rats, des (1-3) insulin-like growth factor-1 increased protein synthesis.
In plain wordsIn lab tests with young rat brain slices, des (1-3) insulin-like growth factor-1 increased protein synthesis.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- IncreaseProtein synthesis in young cortical slices
- Study
ratn: not reported in source
Cerebral cortical slices- Outcome group
- Aging markers · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
Stimulation of cortical slices in vitro with insulin-like growth factor-1, des (1-3) insulin-like growth factor-1, or insulin increased protein synthesis rates in young animals, but the response to these growth factors was blunted in old animals.
1 context sentence(design, population, supporting numbers)
Male Brown Norway rats (5-7 and 27-28 months old) were used to determine (1) whether in vivo protein synthesis in cortex, hippocampus, hypothalamus and cerebellum decreases with age and (2) whether these deficiencies are associated with age-related alterations in response to insulin-like growth fact…