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Study · Animal study (in vivo) · rat · 1995

3 results

Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat.

Mizutani T, Sakata M, Terakawa N

International journal of fertility and menopausal studies1 Mar 1995Cited by 4 (Europe PMC)

PMID7599657 (opens in a new tab)PepBankPUB-07599657
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, endometriosis volume was 1.7 +/- 0.1 cu.-mm after nafarelin (n = 12) versus 26.1 +/- 4.7 cu.-mm in intact controls (n = 13).

    In plain wordsIn rats, endometriosis volume was lower after nafarelin than in intact controls.

    Peptide
    Nafarelin
    Outcome
    DecreaseEndometriosis volume
    Study

    ratn = 25

    Experimental endometriosis under the renal capsule
    Comparator
    Intact control
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The volume of endometriosis in intact control was 26.1 +/- 4.7 cu.-mm (n = 13), 1.7 +/- 0.1 cu.-mm (n = 12) after therapy with nafarelin, 4.8 +/- 1.8 cu.- mm (n = 7) with buserelin, and 3.7 +/- 1.2 cu.-mm (n = 13) with leuprolide.
    1 context sentence
    Summary · context
    METHODS -- Endometriosis was induced in female rats by autotransplantation of endometrium to a site under the renal capsule.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, endometriosis volume after nafarelin was 1.7 +/- 0.1 cu.-mm (n = 12), comparable to castration at 1.9 +/- 0.5 cu.-mm (n = 10).

    In plain wordsIn rats, nafarelin effects on endometriosis volume were comparable to castration.

    Peptide
    Nafarelin
    Outcome
    No significant changeEndometriosis volume versus castration
    Study

    ratn = 22

    Experimental endometriosis under the renal capsule
    Comparator
    Castration
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effects of these compounds were comparable to that of castration (1.9 +/- 0.5 cu.-mm; n = 10).
    2 context sentences
    Summary · context
    The volume of endometriosis in intact control was 26.1 +/- 4.7 cu.-mm (n = 13), 1.7 +/- 0.1 cu.-mm (n = 12) after therapy with nafarelin, 4.8 +/- 1.8 cu.- mm (n = 7) with buserelin, and 3.7 +/- 1.2 cu.-mm (n = 13) with leuprolide.
    Summary · context
    METHODS -- Endometriosis was induced in female rats by autotransplantation of endometrium to a site under the renal capsule.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental endometriosis, nafarelin induced significant atrophy and regression.

    In plain wordsIn rats with experimental endometriosis, nafarelin significantly reduced endometriosis tissue.

    Peptide
    Nafarelin
    Outcome
    DecreaseEndometriosis atrophy and regression
    Study

    ratn: not reported in source

    Experimental endometriosis under the renal capsule
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    RESULTS -- The three GnRH agonists induced significant atrophy and regression of endometriosis.
    1 context sentence
    Summary · context
    METHODS -- Endometriosis was induced in female rats by autotransplantation of endometrium to a site under the renal capsule.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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