Absence of growth hormone (GH) secretion after the administration of either GH-releasing hormone (GHRH), GH-releasing peptide (GHRP-6), or GHRH plus GHRP-6 in children with neonatal pituitary stalk transection.

Pombo M, Barreiro J, Peñalva A, Peino R, Dieguez C, Casanueva FF

The Journal of clinical endocrinology and metabolism1 Nov 1995Cited by 37 (Europe PMC)

PMID7593423DOI10.1210/jcem.80.11.7593423PepBankPUB-07593423

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. 4 results from people.

01HumanNon-randomized trialEfficacy outcome
In normal control subjects, GHRP‑6 elicited a GH secretion (area under the curve) of 1221 +/- 345 micrograms per L/90 min.
In plain wordsIn healthy control subjects, GHRP‑6 caused a rise in growth hormone.
Peptide
GHRP-6
Outcome
Not applicableGH secretion (AUC) after GHRP-6 in normal subjects
Study
n = 7
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microgram/kg · intravenousAs given in this study (human).
Measurements
GH AUC
1221 micrograms per L/90 min
GHRP-6, normal subjects
Source sentences
Summary
In normal subjects, GH secretion was 1029 +/- 202 after GHRH treatment, 1221 +/- 345 after GHRP-6, and 3542 +/- 650 after GHRH plus GHRP-6; the latter value was significantly (P < 0.05) higher than the secretion elicited by GHRH or GHRP-6 alone.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven patients with GH deficiency and different degrees of panhypopituitarism due to perinatal pituitary stalk transection and 7 age- and sex-matched normal controls were studied.
Summary · context
The subjects underwent 3 different tests on separate occasions, being challenged with GHRH (1 microgram/kg, iv), GHRP-6 (1 microgram/kg, iv), or GHRH plus GHRP-6.
Report a problemFND-0759342301
02HumanNon-randomized trialEfficacy outcome
In patients with perinatal pituitary stalk transection, GH after GHRP‑6 was even lower than the already reduced GH after GHRH.
In plain wordsIn patients with pituitary stalk transection, GHRP‑6 caused less growth hormone release than GHRH, which was already low.
Peptide
GHRP-6
Outcome
DecreaseGH secretion (AUC) after GHRP-6 versus GHRH in pituitary stalk transection
Study
n = 7
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microgram/kg · intravenousAs given in this study (human).
Measurements
GH AUC
37 micrograms per L/90 min
GHRP-6, stalk transection
GH AUC
116 micrograms per L/90 min
GHRH, stalk transection
Source sentences
Summary
In the group of patients with perinatal pituitary stalk transection, the level of GH after GHRH treatment was 116 +/- 22 and was even more reduced (P < 0.05) after GHRP-6 treatment (37 +/- 8).
2 context sentences(design, population, supporting numbers)
Summary · context
Seven patients with GH deficiency and different degrees of panhypopituitarism due to perinatal pituitary stalk transection and 7 age- and sex-matched normal controls were studied.
Summary · context
The subjects underwent 3 different tests on separate occasions, being challenged with GHRH (1 microgram/kg, iv), GHRP-6 (1 microgram/kg, iv), or GHRH plus GHRP-6.
Report a problemFND-0759342303
03HumanNon-randomized trialEfficacy outcome
In normal control subjects, GHRH plus GHRP‑6 produced a significantly higher GH secretion than GHRH alone.
In plain wordsIn healthy control subjects, GHRH and GHRP‑6 together raised growth hormone more than GHRH alone.
Peptide
GHRP-6
Outcome
IncreaseGH secretion (AUC) after GHRH plus GHRP-6 versus GHRH alone in normal subjects
Study
n = 7
Comparator
GHRH alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microgram/kg · intravenousAs given in this study (human).
Measurements
GH AUC
3542 micrograms per L/90 min
GHRH plus GHRP-6, normal subjects
GH AUC
1029 micrograms per L/90 min
GHRH alone, normal subjects
Source sentences
Summary
In normal subjects, GH secretion was 1029 +/- 202 after GHRH treatment, 1221 +/- 345 after GHRP-6, and 3542 +/- 650 after GHRH plus GHRP-6; the latter value was significantly (P < 0.05) higher than the secretion elicited by GHRH or GHRP-6 alone.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven patients with GH deficiency and different degrees of panhypopituitarism due to perinatal pituitary stalk transection and 7 age- and sex-matched normal controls were studied.
Summary · context
The subjects underwent 3 different tests on separate occasions, being challenged with GHRH (1 microgram/kg, iv), GHRP-6 (1 microgram/kg, iv), or GHRH plus GHRP-6.
Report a problemFND-0759342306
04HumanNon-randomized trialEfficacy outcome
In patients with perinatal pituitary stalk transection, GHRH plus GHRP‑6 produced a significantly higher GH secretion than GHRH alone.
In plain wordsIn patients with pituitary stalk transection, GHRH and GHRP‑6 together raised growth hormone more than GHRH alone.
Peptide
GHRP-6
Outcome
IncreaseGH secretion (AUC) after GHRH plus GHRP-6 versus GHRH alone in pituitary stalk transection
Study
n = 7
Comparator
GHRH alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microgram/kg · intravenousAs given in this study (human).
Measurements
GH AUC
177 micrograms per L/90 min
GHRH plus GHRP-6, stalk transection
GH AUC
116 micrograms per L/90 min
GHRH alone, stalk transection
Source sentences
Summary
After GHRH plus GHRP-6, GH secretion in those patients was 177 +/- 27, significantly higher (P < 0.05) than the secretion induced by either GHRH or GHRP-6 alone.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven patients with GH deficiency and different degrees of panhypopituitarism due to perinatal pituitary stalk transection and 7 age- and sex-matched normal controls were studied.
Summary · context
The subjects underwent 3 different tests on separate occasions, being challenged with GHRH (1 microgram/kg, iv), GHRP-6 (1 microgram/kg, iv), or GHRH plus GHRP-6.
Report a problemFND-0759342307

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

05HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In normal control subjects, GHRH plus GHRP‑6 produced a GH secretion significantly higher than GHRH alone or GHRP‑6 alone, pooled.
In plain wordsIn healthy control subjects, GHRH and GHRP‑6 together raised growth hormone more than either one alone.
Peptide
GHRP-6
Outcome
IncreaseGH secretion (AUC) after GHRH plus GHRP-6 in normal subjects
Study
n = 7
Comparator
GHRH alone or GHRP-6 alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
3542 micrograms per L/90 min
GHRH plus GHRP-6, normal subjects
Source sentences
Summary
In normal subjects, GH secretion was 1029 +/- 202 after GHRH treatment, 1221 +/- 345 after GHRP-6, and 3542 +/- 650 after GHRH plus GHRP-6; the latter value was significantly (P < 0.05) higher than the secretion elicited by GHRH or GHRP-6 alone.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven patients with GH deficiency and different degrees of panhypopituitarism due to perinatal pituitary stalk transection and 7 age- and sex-matched normal controls were studied.
Summary · context
The subjects underwent 3 different tests on separate occasions, being challenged with GHRH (1 microgram/kg, iv), GHRP-6 (1 microgram/kg, iv), or GHRH plus GHRP-6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0759342302
06HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In patients with perinatal pituitary stalk transection, GHRH plus GHRP‑6 produced a GH secretion significantly higher than GHRH alone or GHRP‑6 alone, pooled.
In plain wordsIn patients with pituitary stalk transection, GHRH and GHRP‑6 together raised growth hormone more than either alone, but the level stayed low.
Peptide
GHRP-6
Outcome
IncreaseGH secretion (AUC) after GHRH plus GHRP-6 in pituitary stalk transection
Study
n = 7
Comparator
GHRH alone or GHRP-6 alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
177 micrograms per L/90 min
GHRH plus GHRP-6, stalk transection
Source sentences
Summary
After GHRH plus GHRP-6, GH secretion in those patients was 177 +/- 27, significantly higher (P < 0.05) than the secretion induced by either GHRH or GHRP-6 alone.
2 context sentences(design, population, supporting numbers)
Summary · context
Seven patients with GH deficiency and different degrees of panhypopituitarism due to perinatal pituitary stalk transection and 7 age- and sex-matched normal controls were studied.
Summary · context
The subjects underwent 3 different tests on separate occasions, being challenged with GHRH (1 microgram/kg, iv), GHRP-6 (1 microgram/kg, iv), or GHRH plus GHRP-6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0759342304
07HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In patients with perinatal pituitary stalk transection, none showed GH secretion greater than 5 micrograms/L after GHRH plus GHRP‑6.
In plain wordsIn patients with pituitary stalk transection, none reached a growth hormone level above 5 micrograms/L after GHRH and GHRP‑6 together.
Peptide
GHRP-6
Outcome
No significant changeProportion of patients with GH above 5 micrograms/L after GHRH plus GHRP-6
Study
n = 7
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH secretion
> 5 micrograms/L
none of the patients, GHRH plus GHRP-6
Source sentences
Summary
Individually examined, none of the patients tested with the most potent stimulus known to date (GHRH plus GHRP-6) exhibited GH secretion greater than 5 micrograms/L
2 context sentences(design, population, supporting numbers)
Summary · context
Seven patients with GH deficiency and different degrees of panhypopituitarism due to perinatal pituitary stalk transection and 7 age- and sex-matched normal controls were studied.
Summary · context
The subjects underwent 3 different tests on separate occasions, being challenged with GHRH (1 microgram/kg, iv), GHRP-6 (1 microgram/kg, iv), or GHRH plus GHRP-6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0759342305

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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