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Study · Randomized controlled trial · n = 5 · 1995

11 results

Short-term endocrine response to gonadotropin-releasing hormone agonist initiated in the early follicular, midluteal, or late luteal phase in normally cycling women.

Gelety TJ, Pearlstone AC, Surrey ES

Fertility and sterility1 Dec 1995Cited by 24 (Europe PMC)

PMID7589655 (opens in a new tab)DOI10.1016/s0015-0282(16)57963-1 (opens in a new tab)PepBankPUB-07589655
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In cycling women, leuprolide-associated LH elevations did not differ by initiation phase and were 4- to 10-fold greater than FSH elevations.

    In plain wordsIn cycling women, LH elevations with leuprolide did not differ between initiation phases.

    Peptide
    Leuprolide
    Outcome
    No significant changeLH elevation by initiation phase
    Study

    n = 5

    Comparator
    Other initiation phases
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Measurements

    LH elevation relative to FSH
    4 to 10 fold
    LH relative to FSH

    Source sentences

    Summary
    Serum LH elevations, 4- to 10-fold greater than observed for FSH, did not differ by cycle day of GnRH-a initiation.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In cycling women, initial FSH increases with leuprolide did not differ by initiation phase.

    In plain wordsInitial FSH increases with leuprolide did not differ between initiation phases.

    Peptide
    Leuprolide
    Outcome
    No significant changeInitial FSH increase by initiation phase
    Study

    n = 5

    Comparator
    Other initiation phases
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Initial increases in FSH did not differ by cycle day, however, early follicular initiation resulted in a more pronounced suppression of FSH.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In cycling women, early follicular leuprolide initiation produced more pronounced FSH suppression than the other phases.

    In plain wordsEarly follicular leuprolide initiation suppressed FSH more than initiation in the other phases.

    Peptide
    Leuprolide
    Outcome
    DecreaseFSH suppression by initiation phase
    Study

    n = 5

    Comparator
    Other initiation phases
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Initial increases in FSH did not differ by cycle day, however, early follicular initiation resulted in a more pronounced suppression of FSH.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).
  4. 04HumanRandomized controlled trialEfficacy outcome

    In cycling women, LH pulse amplitude increased similarly across leuprolide initiation phases.

    In plain wordsLH pulse amplitude increased similarly across leuprolide initiation phases.

    Peptide
    Leuprolide
    Outcome
    Direction not reportedLH pulse amplitude by initiation phase
    Study

    n = 5

    Comparator
    Other initiation phases
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Mean LH pulse amplitude and frequency increased to a similar extent in all three groups, however, FSH pulse amplitude and frequency varied significantly by cycle day of GnRH-a initiation.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).
  5. 05HumanRandomized controlled trialEfficacy outcome

    In cycling women, LH pulse frequency increased similarly across leuprolide initiation phases.

    In plain wordsLH pulse frequency increased similarly across leuprolide initiation phases.

    Peptide
    Leuprolide
    Outcome
    Direction not reportedLH pulse frequency by initiation phase
    Study

    n = 5

    Comparator
    Other initiation phases
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Mean LH pulse amplitude and frequency increased to a similar extent in all three groups, however, FSH pulse amplitude and frequency varied significantly by cycle day of GnRH-a initiation.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).
  6. 06HumanRandomized controlled trialEfficacy outcome

    In cycling women, FSH pulse amplitude varied significantly with leuprolide initiation phase.

    In plain wordsFSH pulse amplitude differed between leuprolide initiation phases.

    Peptide
    Leuprolide
    Outcome
    Direction not reportedFSH pulse amplitude by initiation phase
    Study

    n = 5

    Comparator
    Other initiation phases
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Mean LH pulse amplitude and frequency increased to a similar extent in all three groups, however, FSH pulse amplitude and frequency varied significantly by cycle day of GnRH-a initiation.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).
  7. 07HumanRandomized controlled trialEfficacy outcome

    In cycling women, FSH pulse frequency varied significantly with leuprolide initiation phase.

    In plain wordsFSH pulse frequency differed between leuprolide initiation phases.

    Peptide
    Leuprolide
    Outcome
    Direction not reportedFSH pulse frequency by initiation phase
    Study

    n = 5

    Comparator
    Other initiation phases
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Mean LH pulse amplitude and frequency increased to a similar extent in all three groups, however, FSH pulse amplitude and frequency varied significantly by cycle day of GnRH-a initiation.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).
  8. 08HumanRandomized controlled trialEfficacy outcome

    In cycling women, early follicular leuprolide initiation increased E2, E1 and progesterone significantly compared with midluteal initiation.

    In plain wordsEarly follicular leuprolide initiation increased E2, E1 and progesterone more than midluteal initiation.

    Peptide
    Leuprolide
    Outcome
    IncreaseE2, E1 and progesterone with early follicular initiation
    Study

    n = 5

    Comparator
    Midluteal initiation
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Gonadotropin-releasing hormone agonist initiated in the early follicular phase resulted in significant increases in E2, E1, and P levels compared with both midluteal or late luteal.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).
  9. 09HumanRandomized controlled trialEfficacy outcome

    In cycling women, early follicular leuprolide initiation increased E2, E1 and progesterone significantly compared with late luteal initiation.

    In plain wordsEarly follicular leuprolide initiation increased E2, E1 and progesterone more than late luteal initiation.

    Peptide
    Leuprolide
    Outcome
    IncreaseE2, E1 and progesterone with early follicular initiation
    Study

    n = 5

    Comparator
    Late luteal initiation
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Gonadotropin-releasing hormone agonist initiated in the early follicular phase resulted in significant increases in E2, E1, and P levels compared with both midluteal or late luteal.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).
  10. 10HumanRandomized controlled trialEfficacy outcome

    In cycling women, androgen increases were significantly greater with early follicular than midluteal leuprolide initiation.

    In plain wordsAndrogens increased more with early follicular than midluteal leuprolide initiation.

    Peptide
    Leuprolide
    Outcome
    IncreaseSerum androgen increase with early follicular initiation
    Study

    n = 5

    Comparator
    Midluteal initiation
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Increases in serum androgens were significantly greater after early follicular and late luteal initiation as compared with midluteal GnRH-a initiation.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).
  11. 11HumanRandomized controlled trialEfficacy outcome

    In cycling women, androgen increases were significantly greater with late luteal than midluteal leuprolide initiation.

    In plain wordsAndrogens increased more with late luteal than midluteal leuprolide initiation.

    Peptide
    Leuprolide
    Outcome
    IncreaseSerum androgen increase with late luteal initiation
    Study

    n = 5

    Comparator
    Midluteal initiation
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 mg daily · SC · 5 daysAs given in this study (human).

    Source sentences

    Summary
    Increases in serum androgens were significantly greater after early follicular and late luteal initiation as compared with midluteal GnRH-a initiation.
    2 context sentences
    Summary · context
    Prospective, randomized, controlled crossover study of five regularly cycling women.
    Summary · context
    The GnRH-a, leuprolide acetate (LA), was administered 1 mg SC daily for 5 days beginning on cycle day 3 (early follicular); 8 days post-LH surge (midluteal); or 13 days post-LH surge (late-luteal).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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