In rat pituitary cultures, four novel compound classes did not further increase GH release in combination with GHRP‑6.
In plain wordsIn cells from rats, four novel compound classes did not further increase growth hormone release when combined with GHRP‑6.
- Peptide
- GHRP-6
- Outcome
- No significant changeGH release with novel compounds
- Study
ratn: not reported in source
primary pituitary cell cultures- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
All four new classes further increased GH release in combination with GHRH, but not with GHRP-6.
2 context sentences(design, population, supporting numbers)
The EC50 values for these compounds, determined by GH dose-response curves using primary cultures of rat pituitary cells, were 0.18, 0.34, 10.6, and 0.43 nM, respectively.
To demonstrate that these compounds were acting at the putative GHRP receptor, challenges were made using combinations that included GHRP-6 and GH-releasing hormone (GHRH).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.