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Study · Not a test of the peptide alone · 1995

12 results

Responses of plasma adrenocortical steroids to low dose ACTH in normal subjects.

Daidoh H, Morita H, Mune T, Murayama M, Hanafusa J, Ni H, Shibata H, Yasuda K

Clinical endocrinology1 Sept 1995Cited by 79 (Europe PMC)

PMID7586600 (opens in a new tab)DOI10.1111/j.1365-2265.1995.tb02037.x (opens in a new tab)PepBankPUB-07586600
Publisher pagePubMedAsk about this study
Jump to 12 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone12

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

  1. 01HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, cortisol, aldosterone and DHEA responded to physiological tetracosactide doses in a dose-dependent manner.

    In plain wordsIn healthy volunteers, cortisol, aldosterone and DHEA responses varied with physiological tetracosactide doses.

    Peptide
    Cosyntropin
    Outcome
    Direction not reportedDose-dependent adrenocortical steroid responses
    Study

    n = 7

    Outcome group
    Adrenal Response · Endocrine and hormones

    Source sentences

    Summary
    Each steroid responded to physiological doses of ACTH in a dose dependent manner.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  2. 02HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, 0.5 micrograms tetracosactide was the minimum dose matching peak cortisol with 250 micrograms.

    In plain wordsIn healthy volunteers, 0.5 micrograms tetracosactide matched peak cortisol with 250 micrograms.

    Peptide
    Cosyntropin
    Outcome
    Not applicableMinimum dose for equivalent cortisol peak
    Study

    n = 7

    Comparator
    250 micrograms ACTH
    Outcome group
    Adrenal Response · Endocrine and hormones

    Measurements

    Minimum dose equivalent to 250 micrograms
    0.5 micrograms
    cortisol peak

    Source sentences

    Summary
    The minimum dose inducing an equivalent response to 250 micrograms ACTH was 0.5 micrograms for peak and incremental values in cortisol and DHEA, while that for aldosterone was 0.1 microgram.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  3. 03HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, 0.5 micrograms tetracosactide was the minimum dose matching the cortisol increment with 250 micrograms.

    In plain wordsIn healthy volunteers, 0.5 micrograms tetracosactide matched the cortisol increase with 250 micrograms.

    Peptide
    Cosyntropin
    Outcome
    Not applicableMinimum dose for equivalent cortisol increment
    Study

    n = 7

    Comparator
    250 micrograms ACTH
    Outcome group
    Adrenal Response · Endocrine and hormones

    Measurements

    Minimum dose equivalent to 250 micrograms
    0.5 micrograms
    cortisol increment

    Source sentences

    Summary
    The minimum dose inducing an equivalent response to 250 micrograms ACTH was 0.5 micrograms for peak and incremental values in cortisol and DHEA, while that for aldosterone was 0.1 microgram.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  4. 04HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, 0.5 micrograms tetracosactide was the minimum dose matching peak DHEA with 250 micrograms.

    In plain wordsIn healthy volunteers, 0.5 micrograms tetracosactide matched peak DHEA with 250 micrograms.

    Peptide
    Cosyntropin
    Outcome
    Not applicableMinimum dose for equivalent DHEA peak
    Study

    n = 7

    Comparator
    250 micrograms ACTH
    Outcome group
    Adrenal Response · Endocrine and hormones

    Measurements

    Minimum dose equivalent to 250 micrograms
    0.5 micrograms
    DHEA peak

    Source sentences

    Summary
    The minimum dose inducing an equivalent response to 250 micrograms ACTH was 0.5 micrograms for peak and incremental values in cortisol and DHEA, while that for aldosterone was 0.1 microgram.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  5. 05HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, 0.5 micrograms tetracosactide was the minimum dose matching the DHEA increment with 250 micrograms.

    In plain wordsIn healthy volunteers, 0.5 micrograms tetracosactide matched the DHEA increase with 250 micrograms.

    Peptide
    Cosyntropin
    Outcome
    Not applicableMinimum dose for equivalent DHEA increment
    Study

    n = 7

    Comparator
    250 micrograms ACTH
    Outcome group
    Adrenal Response · Endocrine and hormones

    Measurements

    Minimum dose equivalent to 250 micrograms
    0.5 micrograms
    DHEA increment

    Source sentences

    Summary
    The minimum dose inducing an equivalent response to 250 micrograms ACTH was 0.5 micrograms for peak and incremental values in cortisol and DHEA, while that for aldosterone was 0.1 microgram.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  6. 06HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, 0.1 microgram tetracosactide was the minimum dose matching peak aldosterone with 250 micrograms.

    In plain wordsIn healthy volunteers, 0.1 microgram tetracosactide matched peak aldosterone with 250 micrograms.

    Peptide
    Cosyntropin
    Outcome
    Not applicableMinimum dose for equivalent aldosterone peak
    Study

    n = 7

    Comparator
    250 micrograms ACTH
    Outcome group
    Adrenal Response · Endocrine and hormones

    Measurements

    Minimum dose equivalent to 250 micrograms
    0.1 micrograms
    aldosterone peak

    Source sentences

    Summary
    The minimum dose inducing an equivalent response to 250 micrograms ACTH was 0.5 micrograms for peak and incremental values in cortisol and DHEA, while that for aldosterone was 0.1 microgram.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  7. 07HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, 0.1 microgram tetracosactide was the minimum dose matching the aldosterone increment with 250 micrograms.

    In plain wordsIn healthy volunteers, 0.1 microgram tetracosactide matched the aldosterone increase with 250 micrograms.

    Peptide
    Cosyntropin
    Outcome
    Not applicableMinimum dose for equivalent aldosterone increment
    Study

    n = 7

    Comparator
    250 micrograms ACTH
    Outcome group
    Adrenal Response · Endocrine and hormones

    Measurements

    Minimum dose equivalent to 250 micrograms
    0.1 micrograms
    aldosterone increment

    Source sentences

    Summary
    The minimum dose inducing an equivalent response to 250 micrograms ACTH was 0.5 micrograms for peak and incremental values in cortisol and DHEA, while that for aldosterone was 0.1 microgram.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  8. 08HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, cortisol peaked later as the tetracosactide dose increased.

    In plain wordsIn healthy volunteers, cortisol peaked later with higher tetracosactide doses.

    Peptide
    Cosyntropin
    Outcome
    IncreaseCortisol time to peak
    Study

    n = 7

    Outcome group
    Adrenal Response · Endocrine and hormones

    Source sentences

    Summary
    The time to peak for each steroid was delayed as the dose increased.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  9. 09HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, aldosterone peaked later as the tetracosactide dose increased.

    In plain wordsIn healthy volunteers, aldosterone peaked later with higher tetracosactide doses.

    Peptide
    Cosyntropin
    Outcome
    IncreaseAldosterone time to peak
    Study

    n = 7

    Outcome group
    Adrenal Response · Endocrine and hormones

    Source sentences

    Summary
    The time to peak for each steroid was delayed as the dose increased.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  10. 10HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, DHEA peaked later as the tetracosactide dose increased.

    In plain wordsIn healthy volunteers, DHEA peaked later with higher tetracosactide doses.

    Peptide
    Cosyntropin
    Outcome
    IncreaseDHEA time to peak
    Study

    n = 7

    Outcome group
    Adrenal Response · Endocrine and hormones

    Source sentences

    Summary
    The time to peak for each steroid was delayed as the dose increased.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  11. 11HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, aldosterone peaked earlier than cortisol in 1-5 micrograms tetracosactide tests.

    In plain wordsIn healthy volunteers, aldosterone peaked earlier than cortisol in 1-5 micrograms tetracosactide tests.

    Peptide
    Cosyntropin
    Outcome
    DecreaseAldosterone versus cortisol peak timing
    Study

    n = 7

    Comparator
    Cortisol peak timing
    Outcome group
    Adrenal Response · Endocrine and hormones

    Source sentences

    Summary
    Plasma aldosterone and DHEA peaked significantly earlier than plasma cortisol in 1-5 micrograms and 0.5-5-micrograms ACTH tests, respectively.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  12. 12HumanNot a test of Cosyntropin aloneNon-randomized trialOther

    In healthy volunteers, DHEA peaked earlier than cortisol in 0.5-5-micrograms tetracosactide tests.

    In plain wordsIn healthy volunteers, DHEA peaked earlier than cortisol in 0.5-5-micrograms tetracosactide tests.

    Peptide
    Cosyntropin
    Outcome
    DecreaseDHEA versus cortisol peak timing
    Study

    n = 7

    Comparator
    Cortisol peak timing
    Outcome group
    Adrenal Response · Endocrine and hormones

    Source sentences

    Summary
    Plasma aldosterone and DHEA peaked significantly earlier than plasma cortisol in 1-5 micrograms and 0.5-5-micrograms ACTH tests, respectively.
    2 context sentences
    Summary · context
    We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of ACTH (ACTH 1-24, tetracosactide, Cortrosyn) and determined the minimal dose which induces a response equivalent to that induced by a pharma…
    Summary · context
    Rapid ACTH tests at various physiological (0-1, 0.5, 1 and 5 micrograms) and standard pharmacological (250 micrograms) intravenous doses.SubjectsSeven healthy normal volunteers.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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