Growth hormone-releasing effect of oral growth hormone-releasing peptide 6 (GHRP-6) administration in children with short stature.

Bellone J, Ghizzoni L, Aimaretti G, Volta C, Boghen MF, Bernasconi S, Ghigo E

European journal of endocrinology1 Oct 1995Cited by 19 (Europe PMC)

PMID7581965DOI10.1530/eje.0.1330425PepBankPUB-07581965

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

01HumanNon-randomized trialEfficacy outcome
In children with normal short stature, oral GHRP‑6 raised the GH peak above baseline.
In plain wordsIn children with normal short stature, oral GHRP‑6 raised growth hormone above the starting level.
Peptide
GHRP-6
Outcome
IncreaseGH peak after oral GHRP-6
Study
n = 7
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
300 micrograms/kg · oralAs given in this study (human).
Measurements
GH peak
18.8 micrograms/l
oral GHRP-6
GH baseline
1.1 micrograms/l
before GHRP-6
Source sentences
Summary
oral GHRP-6 administration induced a GH response (mean +/- SEM; peak at 60 min vs baseline: 18.8 +/- 3.0 vs 1.1 +/- 0.3 micrograms/l, p < 0.0006
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of oral GHRP-6 (300 micrograms/kg) was compared with that of the maximally effective dose of intravenous GH-releasing hormone (GHRH-29, 1 microgram/kg).
Summary · context
We studied 13 children (nine boys and four girls aged 6.2-10.5 years, pubertal stage I) with normal short stature (height less than -2 SD score; height velocity more than -2 SD score; normal bone age; insulin-like growth factor I > 70 micrograms/l).
Report a problemFND-0758196501
02HumanNon-randomized trialEfficacy outcome
In children with normal short stature, the GH response to oral GHRP‑6 was similar to that to intravenous GHRH.
In plain wordsIn children with normal short stature, oral GHRP‑6 raised growth hormone about as much as an injected GHRH dose.
Peptide
GHRP-6
Outcome
No significant changeGH response to oral GHRP-6 compared with intravenous GHRH
Study
n = 7
Comparator
Intravenous GHRH-29 1 microgram/kg
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
300 micrograms/kg · oralAs given in this study (human).
Measurements
GH AUC
1527.3 micrograms l-1 h-1
oral GHRP-6
GH AUC
1429.4 micrograms l-1 h-1
GHRH
Source sentences
Summary
oral GHRP-6 administration induced a GH response (mean +/- SEM; peak at 60 min vs baseline: 18.8 +/- 3.0 vs 1.1 +/- 0.3 micrograms/l, p < 0.0006; area under curve: 1527.3 +/- 263.9 micrograms l-1 h-1) which was similar to that elicited by GHRH (peak at 45 min vs baseline: 20.8 +/- 4.5 vs 2.2 +/- 0.9…
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of oral GHRP-6 (300 micrograms/kg) was compared with that of the maximally effective dose of intravenous GH-releasing hormone (GHRH-29, 1 microgram/kg).
Summary · context
We studied 13 children (nine boys and four girls aged 6.2-10.5 years, pubertal stage I) with normal short stature (height less than -2 SD score; height velocity more than -2 SD score; normal bone age; insulin-like growth factor I > 70 micrograms/l).
Report a problemFND-0758196502

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

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