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Study · Animal study (in vivo) · rat · 1995

6 results

[The effect of the intranigral use of the delta sleep-inducing peptide and its analogs on the motor and seizure activities of rats].

Shandra AA, Godlevskiĭ LS, Vast'ianov RS, Brusentsov AI, Mikhaleva II, Prudchenko IA, Zaporozhan VN

Fiziologicheskii zhurnal imeni I.M. Sechenova1 Feb 1995Cited by 1 (Europe PMC)

PMID7581535 (opens in a new tab)PepBankPUB-07581535
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intranigral microinjection of delta-sleep-inducing peptide, as well as its analogues DSIP-1 to DSIP-4, decreased horizontal locomotor activity.

    In plain wordsIn rats, delta sleep-inducing peptide injected into the substantia nigra reduced horizontal movement.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseHorizontal locomotor activity
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranigral microinjectionAs given in this study (rat).

    Source sentences

    Summary
    It was shown that intranigral microinjection of DSIP as well as DSIP-1-DSIP-4 caused decreasing of horizontal, vertical locomotor activity and attendance of central sectors of the "open field".
    1 context sentence
    Summary · context
    The effects of delta-sleep inducing peptide (DSIP) and its analogues (1-4) administered into substantia nigra pars reticulata on locomotor and seizure activity were estimated in experiments in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intranigral microinjection of delta-sleep-inducing peptide, as well as its analogues DSIP-1 to DSIP-4, decreased vertical locomotor activity.

    In plain wordsIn rats, delta sleep-inducing peptide injected into the substantia nigra reduced vertical movement.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseVertical locomotor activity
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranigral microinjectionAs given in this study (rat).

    Source sentences

    Summary
    It was shown that intranigral microinjection of DSIP as well as DSIP-1-DSIP-4 caused decreasing of horizontal, vertical locomotor activity and attendance of central sectors of the "open field".
    1 context sentence
    Summary · context
    The effects of delta-sleep inducing peptide (DSIP) and its analogues (1-4) administered into substantia nigra pars reticulata on locomotor and seizure activity were estimated in experiments in rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intranigral microinjection of delta-sleep-inducing peptide, as well as its analogues DSIP-1 to DSIP-4, decreased attendance of central sectors of the open field.

    In plain wordsIn rats, delta sleep-inducing peptide injected into the substantia nigra reduced visits to the centre of the open field.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseAttendance of central sectors of the open field
    Study

    ratn: not reported in source

    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranigral microinjectionAs given in this study (rat).

    Source sentences

    Summary
    It was shown that intranigral microinjection of DSIP as well as DSIP-1-DSIP-4 caused decreasing of horizontal, vertical locomotor activity and attendance of central sectors of the "open field".
    1 context sentence
    Summary · context
    The effects of delta-sleep inducing peptide (DSIP) and its analogues (1-4) administered into substantia nigra pars reticulata on locomotor and seizure activity were estimated in experiments in rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, delta-sleep-inducing peptide, DSIP-2 and DSIP-3 lengthened the latent period of the first picrotoxin-induced convulsion.

    In plain wordsIn rats, delta sleep-inducing peptide delayed the first picrotoxin-induced convulsion.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLatent period of the first picrotoxin-induced convulsion
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranigral microinjectionAs given in this study (rat).

    Source sentences

    Summary
    Antiseizure effects, i.e. the first and clonic-tonic picrotoxin-induced convulsive latent period lengthening and their intensity decreasing, revealed DSIP, DSIP-2 and DSIP-3.
    1 context sentence
    Summary · context
    The effects of delta-sleep inducing peptide (DSIP) and its analogues (1-4) administered into substantia nigra pars reticulata on locomotor and seizure activity were estimated in experiments in rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, delta-sleep-inducing peptide, DSIP-2 and DSIP-3 lengthened the latent period of the clonic-tonic picrotoxin-induced convulsion.

    In plain wordsIn rats, delta sleep-inducing peptide delayed the clonic-tonic picrotoxin-induced convulsion.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLatent period of clonic-tonic picrotoxin-induced convulsion
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranigral microinjectionAs given in this study (rat).

    Source sentences

    Summary
    Antiseizure effects, i.e. the first and clonic-tonic picrotoxin-induced convulsive latent period lengthening and their intensity decreasing, revealed DSIP, DSIP-2 and DSIP-3.
    1 context sentence
    Summary · context
    The effects of delta-sleep inducing peptide (DSIP) and its analogues (1-4) administered into substantia nigra pars reticulata on locomotor and seizure activity were estimated in experiments in rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, delta-sleep-inducing peptide, DSIP-2 and DSIP-3 decreased the intensity of picrotoxin-induced convulsions.

    In plain wordsIn rats, delta sleep-inducing peptide reduced the intensity of picrotoxin-induced convulsions.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseIntensity of picrotoxin-induced convulsions
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intranigral microinjectionAs given in this study (rat).

    Source sentences

    Summary
    Antiseizure effects, i.e. the first and clonic-tonic picrotoxin-induced convulsive latent period lengthening and their intensity decreasing, revealed DSIP, DSIP-2 and DSIP-3.
    1 context sentence
    Summary · context
    The effects of delta-sleep inducing peptide (DSIP) and its analogues (1-4) administered into substantia nigra pars reticulata on locomotor and seizure activity were estimated in experiments in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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