Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig.

Conlon MA, Tomas FM, Owens PC, Wallace JC, Howarth GS, Ballard FJ

The Journal of endocrinology1 Aug 1995Cited by 16 (Europe PMC)

PMID7561636DOI10.1677/joe.0.1460247PepBankPUB-07561636

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In female guinea pigs, 7 days of long R3 IGF-I infusion did not significantly change body weight gain.
In plain wordsIn guinea pigs, long R3 IGF-I infusion did not significantly change weight gain.
Peptide
IGF-1 LR3
Outcome
No significant changeBody weight gain
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Body weight · Metabolic and weight
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Summary
Nevertheless, body weight gain, feed intake, feed conversion efficiency and carcass composition were not significantly affected by any treatment (significance was deemed to be P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163601
02AnimalAnimal study (in vivo)Efficacy outcome
In female guinea pigs, 7 days of long R3 IGF-I infusion did not significantly change feed intake.
In plain wordsIn guinea pigs, long R3 IGF-I infusion did not significantly change food intake.
Peptide
IGF-1 LR3
Outcome
No significant changeFeed intake
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Summary
Nevertheless, body weight gain, feed intake, feed conversion efficiency and carcass composition were not significantly affected by any treatment (significance was deemed to be P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163602
03AnimalAnimal study (in vivo)Efficacy outcome
In female guinea pigs, 7 days of long R3 IGF-I infusion did not significantly change feed conversion efficiency.
In plain wordsIn guinea pigs, long R3 IGF-I infusion did not significantly change how well food turned into weight.
Peptide
IGF-1 LR3
Outcome
No significant changeFeed conversion efficiency
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Body weight · Metabolic and weight
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Summary
Nevertheless, body weight gain, feed intake, feed conversion efficiency and carcass composition were not significantly affected by any treatment (significance was deemed to be P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163603
04AnimalAnimal study (in vivo)Efficacy outcome
In female guinea pigs, 7 days of long R3 IGF-I infusion did not significantly change carcass composition.
In plain wordsIn guinea pigs, long R3 IGF-I infusion did not significantly change body composition.
Peptide
IGF-1 LR3
Outcome
No significant changeCarcass composition
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Body weight · Metabolic and weight
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Summary
Nevertheless, body weight gain, feed intake, feed conversion efficiency and carcass composition were not significantly affected by any treatment (significance was deemed to be P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163604
05AnimalAnimal study (in vivo)Efficacy outcome
In female guinea pigs, long R3 IGF-I significantly increased the fractional weight of the adrenals, but overall growth was not stimulated.
In plain wordsIn guinea pigs, long R3 IGF-I increased adrenal weight relative to body weight, but overall growth did not rise.
Peptide
IGF-1 LR3
Outcome
IncreaseFractional adrenal weight
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Body composition · Whole body
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Summary
However, the fractional weight of adrenals, gut, kidneys and spleen were significantly increased by LR3IGF-I, but again overall growth was not stimulated.
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163605
06AnimalAnimal study (in vivo)Efficacy outcome
In female guinea pigs, long R3 IGF-I significantly increased the fractional weight of the gut, but overall growth was not stimulated.
In plain wordsIn guinea pigs, long R3 IGF-I increased gut weight relative to body weight, but overall growth did not rise.
Peptide
IGF-1 LR3
Outcome
IncreaseFractional gut weight
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Body composition · Whole body
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Summary
However, the fractional weight of adrenals, gut, kidneys and spleen were significantly increased by LR3IGF-I, but again overall growth was not stimulated.
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163606
07AnimalAnimal study (in vivo)Efficacy outcome
In female guinea pigs, long R3 IGF-I significantly increased the fractional weight of the kidneys, but overall growth was not stimulated.
In plain wordsIn guinea pigs, long R3 IGF-I increased kidney weight relative to body weight, but overall growth did not rise.
Peptide
IGF-1 LR3
Outcome
IncreaseFractional kidney weight
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Body composition · Whole body
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Summary
However, the fractional weight of adrenals, gut, kidneys and spleen were significantly increased by LR3IGF-I, but again overall growth was not stimulated.
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163607
08AnimalAnimal study (in vivo)Efficacy outcome
In female guinea pigs, long R3 IGF-I significantly increased the fractional weight of the spleen, but overall growth was not stimulated.
In plain wordsIn guinea pigs, long R3 IGF-I increased spleen weight relative to body weight, but overall growth did not rise.
Peptide
IGF-1 LR3
Outcome
IncreaseFractional spleen weight
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Body composition · Whole body
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Summary
However, the fractional weight of adrenals, gut, kidneys and spleen were significantly increased by LR3IGF-I, but again overall growth was not stimulated.
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163608
09AnimalAnimal study (in vivo)Efficacy outcome
In guinea pigs, long R3 IGF-I infusion reduced plasma IGF-I concentrations.
In plain wordsIn guinea pigs, long R3 IGF-I infusion lowered the body's own IGF-I in the blood.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma IGF-I
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Title
Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig.
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163609
10AnimalAnimal study (in vivo)Efficacy outcome
In guinea pigs, long R3 IGF-I infusion reduced plasma IGF-II concentrations.
In plain wordsIn guinea pigs, long R3 IGF-I infusion lowered the body's own IGF-II in the blood.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma IGF-II
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Title
Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig.
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163610
11AnimalAnimal study (in vivo)Efficacy outcome
In guinea pigs, long R3 IGF-I infusion reduced plasma IGF binding protein concentrations.
In plain wordsIn guinea pigs, long R3 IGF-I infusion lowered IGF binding protein levels in the blood.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma IGF binding protein
Study
guinea pign: not reported in source
Female guinea pigs, 350 g
Comparator
Vehicle-infused animals
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
120 micrograms/day · 7 daysAs given in this study (guinea pig).
Source sentences
Title
Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig.
1 context sentence(design, population, supporting numbers)
Summary · context
Female guinea pigs of 350 g body weight were continuously infused for 7 days with recombinant guinea pig IGF-I or -II (120 or 360 micrograms/day) or long R3 IGF-I (LR3IGF-I) (120 micrograms/day), an analogue which has much reduced affinities for IGF binding proteins.
Report a problemFND-0756163611

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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