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Study · Animal study (in vivo) · rat · 1995

1 result

Degradation of IGF-I in the adult rat gastrointestinal tract is limited by a specific antiserum or the dietary protein casein.

Xian CJ, Shoubridge CA, Read LC

The Journal of endocrinology1 Aug 1995Cited by 31 (Europe PMC)

PMID7561632 (opens in a new tab)DOI10.1677/joe.0.1460215 (opens in a new tab)PepBankPUB-07561632
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In adult rats, the extension peptide on the analogue LR3IGF-I did not protect IGF-I from degradation in the upper gut.

    In plain wordsIn rats, the added tail on LR3IGF-I did not protect IGF-I from breakdown in the upper gut.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeGut survival of IGF-I with the LR3IGF-I extension peptide
    Study

    ratn: not reported in source

    Ligated gut segments of fasted adult rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the extension peptide on the analogue, LR3IGF-I did not protect IGF-I
    1 context sentence
    Summary · context
    To investigate the potential of IGF-I peptides as therapeutics in the gut, the survival profiles of a bolus of 125I-labelled IGF-I (8.6 ng) in vivo in various ligated gut segments of fasted adult rats have been examined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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