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Study · Non-randomized trial · n = 24 · 1995

7 results

Diagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature.

Pihoker C, Middleton R, Reynolds GA, Bowers CY, Badger TM

The Journal of clinical endocrinology and metabolism1 Oct 1995Cited by 24 (Europe PMC)

PMID7559885 (opens in a new tab)DOI10.1210/jcem.80.10.7559885 (opens in a new tab)PepBankPUB-07559885
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In children evaluated for GH deficiency, GH responses to GHRP‑2 and GHRH were similar in each child, and both were equally reliable predictors of pituitary reserve.

    In plain wordsIn children evaluated for GH deficiency, GHRP‑2 and GHRH gave similar growth hormone responses and predicted pituitary reserve equally well.

    Peptide
    GHRP-2
    Outcome
    No significant changeGH responses to GHRP-2 versus GHRH
    Study

    n = 24

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    The GH responses to GHRH or GHRP-2 were similar in each child, and both were equally reliable predictors of pituitary reserve.
    2 context sentences
    Summary · context
    GHRP-2 was administered iv or intranasally to children with short stature.
    Summary · context
    Twenty-four children undergoing evaluation for GH deficiency received at least one conventional agent (arginine, L-dopa/exercise, insulin) in addition to iv GHRH and GHRP-2.
  2. 02HumanNon-randomized trialEfficacy outcome

    In children evaluated for GH deficiency, conventional GH tests were less likely to predict pituitary GH capacity than GHRP‑2 or GHRH.

    In plain wordsIn children evaluated for GH deficiency, GHRP‑2 predicted the pituitary's growth hormone capacity better than conventional tests did.

    Peptide
    GHRP-2
    Outcome
    IncreasePredictive value of GHRP-2 test for pituitary GH capacity
    Study

    n = 24

    Comparator
    Conventional agents (arginine, L-dopa/exercise, insulin)
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    The conventional agents used in GH testing were less likely to predict the capacity of the pituitary to release GH than were either GHRH or GHRP-2.
    2 context sentences
    Summary · context
    GHRP-2 was administered iv or intranasally to children with short stature.
    Summary · context
    Twenty-four children undergoing evaluation for GH deficiency received at least one conventional agent (arginine, L-dopa/exercise, insulin) in addition to iv GHRH and GHRP-2.
  3. 03HumanNon-randomized trialEfficacy outcome

    In children evaluated for GH deficiency, maximal GH response to standard tests did not correlate with GH responses to GHRH or GHRP‑2.

    In plain wordsIn children evaluated for GH deficiency, results of standard tests did not match growth hormone responses to GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    No significant changeCorrelation of GHRP-2 GH response with standard tests
    Study

    n = 24

    Comparator
    Standard GH tests
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    There was no correlation between maximal GH response to standard tests with GH responses to GHRH or GHRP-2.
    2 context sentences
    Summary · context
    GHRP-2 was administered iv or intranasally to children with short stature.
    Summary · context
    Twenty-four children undergoing evaluation for GH deficiency received at least one conventional agent (arginine, L-dopa/exercise, insulin) in addition to iv GHRH and GHRP-2.
  4. 04HumanNon-randomized trialEfficacy outcome

    In children of short stature, all 15 children had a significant GH response to intranasal GHRP‑2 over a dose range of 5-20 micrograms/kg per dose.

    In plain wordsIn children of short stature, nasal GHRP‑2 produced a significant growth hormone response in all 15 children tested.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH response to intranasal GHRP-2
    Study

    n = 15

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5-20 micrograms/kg per dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    All 15 of these children had a significant GH response to intranasal GHRP-2 over a dose range of 5-20 micrograms/kg per dose.
    2 context sentences
    Summary · context
    GHRP-2 was administered iv or intranasally to children with short stature.
    Summary · context
    Twenty-four children undergoing evaluation for GH deficiency received at least one conventional agent (arginine, L-dopa/exercise, insulin) in addition to iv GHRH and GHRP-2.
  5. 05HumanNon-randomized trialEfficacy outcome

    In children of short stature, the mean peak GH response to intranasal GHRP‑2 at 15 micrograms/kg was 31.3 micrograms/L.

    In plain wordsIn children of short stature, nasal GHRP‑2 at 15 micrograms/kg produced a mean peak growth hormone level of 31.3 micrograms/L.

    Peptide
    GHRP-2
    Outcome
    IncreaseMean peak GH after intranasal GHRP-2 at 15 micrograms/kg
    Study

    n = 15

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    15 micrograms/kg · intranasalAs given in this study (human).

    Measurements

    Mean peak GH
    31.3 micrograms/L
    15 micrograms/kg intranasal

    Source sentences

    Summary
    The mean peak GH response to 15 micrograms/kg was 31.3 micrograms/L.
    2 context sentences
    Summary · context
    GHRP-2 was administered iv or intranasally to children with short stature.
    Summary · context
    Twenty-four children undergoing evaluation for GH deficiency received at least one conventional agent (arginine, L-dopa/exercise, insulin) in addition to iv GHRH and GHRP-2.
  6. 06HumanNon-randomized trialSafety outcome

    In children of short stature, the intranasal GHRP‑2 preparation was well tolerated.

    In plain wordsIn children of short stature, the nasal GHRP‑2 preparation was well tolerated.

    Peptide
    GHRP-2
    Outcome
    Not applicableTolerability of intranasal GHRP-2
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    The intranasal preparation was well tolerated.
    2 context sentences
    Summary · context
    GHRP-2 was administered iv or intranasally to children with short stature.
    Summary · context
    Twenty-four children undergoing evaluation for GH deficiency received at least one conventional agent (arginine, L-dopa/exercise, insulin) in addition to iv GHRH and GHRP-2.

Studies that did not test the peptide alone1

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 07HumanNot a test of GHRP-2 aloneNon-randomized trialEfficacy outcome

    In children of short stature with a robust response to GHRP‑2, the GH response to GHRH plus GHRP‑2 was synergistic.

    In plain wordsIn children of short stature, GHRH and GHRP‑2 given together produced a larger growth hormone response than expected from each alone.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH response to GHRH+GHRP-2
    Study

    n = 12

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The GH response to GHRH+GHRP-2 was synergistic in this group of 12 children, similar to previously reported observations in adults of normal stature.
    2 context sentences
    Summary · context
    GHRP-2 was administered iv or intranasally to children with short stature.
    Summary · context
    Twenty-four children undergoing evaluation for GH deficiency received at least one conventional agent (arginine, L-dopa/exercise, insulin) in addition to iv GHRH and GHRP-2.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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