In skeletal muscle cells, dexamethasone enhanced the actions of the IGF-I analogue long R3IGF-I, similar to its effects on insulin and PDGF-BB, so IGF-binding proteins did not explain it.
In plain wordsIn muscle cells in the lab, dexamethasone boosted the action of long R3IGF-I, just as it did for insulin and PDGF-BB.
- Peptide
- IGF-1 LR3
- Outcome
- IncreaseDexamethasone effect on the action of long R3IGF-I
- Study
n: not reported in source
Skeletal muscle cells- Outcome group
- Muscle injury and repair · Musculoskeletal
Source sentences
The effect of dexamethasone is not mediated by changes in IGF-binding proteins, as evidenced by similar effects of dexamethasone on the actions of insulin, PDGF-BB, and the IGF-I analogue long R3IGF-I.
2 context sentences(design, population, supporting numbers)
IGF-I stimulation of cell proliferation and c-Fos expression in skeletal muscle cells is markedly enhanced by dexamethasone.
Dexamethasone enhances insulin-like growth factor-I effects on skeletal muscle cell proliferation. Role of specific intracellular signaling pathways.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.