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Study · In vitro (cells) · bovine and ovine · 1995

6 results

Insulin-like growth factor binding proteins (IGF-BPs) in bovine articular and ovine growth-plate chondrocyte cultures: their regulation by IGFs and modulation of proteoglycan synthesis.

Sunic D, Belford DA, McNeil JD, Wiebkin OW

Biochimica et biophysica acta1 Aug 1995Cited by 17 (Europe PMC)

PMID7544626 (opens in a new tab)DOI10.1016/0304-4165(95)00076-n (opens in a new tab)PepBankPUB-07544626
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In bovine articular chondrocytes, des(1‑3)IGF-I stimulated IGF-binding protein production.

    In plain wordsIn cells, des(1‑3)IGF-I increased IGF-binding protein production in bovine articular chondrocytes.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGF-binding protein production in articular chondrocytes
    Study

    bovinen: not reported in source

    Bovine articular chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both growth factors stimulated the production of IGF-BPs in articular and growth-plate chondrocyte monolayers.
    1 context sentence
    Summary · context
    To investigate the biological effects of IGFs and IGF-BPs, isolated bovine articular and ovine growth-plate chondrocytes were cultured at high density in the presence of IGF-1, and its truncated form, des (1-3) IGF-I.
  2. 02LabIn vitro (cells)Efficacy outcome

    In ovine growth-plate chondrocytes, des(1‑3)IGF-I stimulated IGF-binding protein production.

    In plain wordsIn cells, des(1‑3)IGF-I increased IGF-binding protein production in ovine growth-plate chondrocytes.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGF-binding protein production in growth-plate chondrocytes
    Study

    ovinen: not reported in source

    Ovine growth-plate chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both growth factors stimulated the production of IGF-BPs in articular and growth-plate chondrocyte monolayers.
    1 context sentence
    Summary · context
    To investigate the biological effects of IGFs and IGF-BPs, isolated bovine articular and ovine growth-plate chondrocytes were cultured at high density in the presence of IGF-1, and its truncated form, des (1-3) IGF-I.
  3. 03LabIn vitro (cells)Efficacy outcome

    In bovine articular chondrocytes, des(1‑3)IGF-I stimulated total proteoglycan synthesis up to 1.5-fold.

    In plain wordsIn cells, des(1‑3)IGF-I increased total proteoglycan synthesis up to 1.5-fold in bovine articular chondrocytes.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseTotal articular proteoglycan synthesis
    Study

    bovinen: not reported in source

    Bovine articular chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Proteoglycan synthesis stimulation
    1.5 fold
    up to; articular chondrocytes

    Source sentences

    Summary
    IGF-I and des (1-3) IGF-I stimulated total proteoglycan synthesis by articular chondrocytes up to 1.5-fold.
  4. 04LabIn vitro (cells)Efficacy outcome

    In bovine articular chondrocytes, des(1‑3)IGF-I was more potent than IGF-I at lower concentrations in stimulating proteoglycan synthesis.

    In plain wordsIn cells, des(1‑3)IGF-I stimulated proteoglycan synthesis more potently than IGF-I at lower concentrations.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseProteoglycan synthesis potency at lower concentrations
    Study

    bovinen: not reported in source

    Bovine articular chondrocytes
    Comparator
    IGF-I
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The truncated analogue was more potent at lower concentrations, particularly in stimulating incorporation of newly synthesized proteoglycans into the cell-layer.
    1 context sentence
    Summary · context
    IGF-I and des (1-3) IGF-I stimulated total proteoglycan synthesis by articular chondrocytes up to 1.5-fold.
  5. 05LabIn vitro (cells)Efficacy outcome

    In bovine articular chondrocytes, des(1‑3)IGF-I more potently stimulated proteoglycan incorporation into the cell layer than IGF-I at lower concentrations.

    In plain wordsIn cells, des(1‑3)IGF-I increased proteoglycan incorporation into the cell layer more potently than IGF-I at lower concentrations.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseCell-layer incorporation of newly synthesized proteoglycans
    Study

    bovinen: not reported in source

    Bovine articular chondrocytes
    Comparator
    IGF-I
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The truncated analogue was more potent at lower concentrations, particularly in stimulating incorporation of newly synthesized proteoglycans into the cell-layer.
    1 context sentence
    Summary · context
    IGF-I and des (1-3) IGF-I stimulated total proteoglycan synthesis by articular chondrocytes up to 1.5-fold.
  6. 06LabIn vitro (cells)Efficacy outcome

    In ovine growth-plate chondrocytes, maximal proteoglycan synthesis stimulation was 3-fold with des(1‑3)IGF-I versus 2-fold with IGF-I over the tested concentrations.

    In plain wordsIn cells, des(1‑3)IGF-I increased proteoglycan synthesis up to 3-fold, compared with 2-fold for IGF-I in ovine growth-plate chondrocytes.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseGrowth-plate proteoglycan synthesis
    Study

    ovinen: not reported in source

    Ovine growth-plate chondrocytes
    Comparator
    IGF-I
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Maximal proteoglycan synthesis stimulation
    3 fold
    des(1-3)IGF-I
    Proteoglycan synthesis stimulation
    2 fold
    IGF-I; over the concentrations used

    Source sentences

    Summary
    The maximal stimulation of proteoglycan synthesis in ovine growth-plate chondrocyte culture was 3-fold with des (1-3) IGF-I, while IGF-I enhanced proteoglycan production by only 2-fold over the concentrations used.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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