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Study · In vitro (cells) · 1995

2 results

Differential regulation by TGF-beta 1 and insulin of insulin-like growth factor binding protein-2 in IEC-6 cells.

Guo YS, Townsend CM Jr, Jin GF, Beauchamp RD, Thompson JC

The American journal of physiology1 Jun 1995Cited by 12 (Europe PMC)

PMID7541944 (opens in a new tab)DOI10.1152/ajpendo.1995.268.6.e1199 (opens in a new tab)PepBankPUB-07541944
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In IEC-6 cells, des(1‑3)IGF-I stimulated proliferation.

    In plain wordsIn cells, des(1‑3)IGF-I increased cell growth.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIEC-6 cell proliferation
    Study

    n: not reported in source

    IEC-6 cells
    Outcome group
    Cell proliferation and differentiation · Gastrointestinal
    Studied dose
    50 ng/mlAs given in this study.

    Source sentences

    Summary
    In addition, des (1-3) IGF-I (50 ng/ml) and insulin stimulated the proliferation of IEC-6 cells.

Studies that did not test the peptide alone1

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 02LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    In IEC-6 cells, anti-IGFBP-2 antibodies partially blocked the growth-inhibitory role attributed to des(1‑3)IGF-I.

    In plain wordsIn cells, anti-IGFBP-2 antibodies partly blocked the growth inhibition attributed to des(1‑3)IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseAntibody blockade of growth inhibition
    Study

    n: not reported in source

    IEC-6 cells
    Outcome group
    Cell proliferation and differentiation · Gastrointestinal

    Source sentences

    Summary
    Anti-IGFBP-2 antibodies partially blocked the inhibitory role in IEC-6 cell growth evoked by des (1-3) IGF-I.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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