Cyclic nucleotides and vasoactive intestinal peptide production in a rabbit model of Escherichia coli septicemia.

Broner CW, O'Dorisio MS, Rosenberg RB, O'Dorisio TM

The American journal of the medical sciences1 May 1995Cited by 7 (Europe PMC)

PMID7537447DOI10.1097/00000441-199530950-00006PepBankPUB-07537447

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, infusion of VIP produced profound hypotension.
In plain wordsIn rabbits, giving VIP by infusion caused a strong fall in blood pressure.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseBlood pressure during VIP infusion
Study
rabbitn: not reported in source
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · infusionAs given in this study (rabbit).
Source sentences
Summary
Infusion of VIP produced profound hypotension and lactic acidemia.
2 context sentences(design, population, supporting numbers)
Summary · context
Cyclic nucleotides and VIP were evaluated during Escherichia coli septicemia in two groups of rabbits; 1) sepsis alone and 2) sepsis and a competitive inhibitor of nitric oxide synthase, NG-monomethyl-L-arginine.
Summary · context
Arterial blood was obtained for determination of bacteremia, lactic acidemia, nucleotides, nitrites, and VIP levels.
Report a problemFND-0753744703
02AnimalAnimal study (in vivo)Safety outcome
In rabbits, infusion of VIP produced lactic acidemia.
In plain wordsIn rabbits, giving VIP by infusion caused a build-up of lactic acid in the blood.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseLactic acidemia during VIP infusion
Study
rabbitn: not reported in source
Outcome group
Metabolic pathways and metabolomics · Metabolic and weight
Studied dose
Dose not stated · infusionAs given in this study (rabbit).
Source sentences
Summary
Infusion of VIP produced profound hypotension and lactic acidemia.
2 context sentences(design, population, supporting numbers)
Summary · context
Cyclic nucleotides and VIP were evaluated during Escherichia coli septicemia in two groups of rabbits; 1) sepsis alone and 2) sepsis and a competitive inhibitor of nitric oxide synthase, NG-monomethyl-L-arginine.
Summary · context
Arterial blood was obtained for determination of bacteremia, lactic acidemia, nucleotides, nitrites, and VIP levels.
Report a problemFND-0753744704

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

03AnimalEndogenous levelAnimal study (in vivo)Other
In rabbits with E. coli septicemia, circulating VIP levels increased with the development of shock.
In plain wordsIn rabbits with severe infection, the body's own VIP in blood rose as shock developed.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseCirculating VIP during septic shock
Study
rabbitn: not reported in source
Escherichia coli septicemia
Outcome group
Endogenous peptide levels · Infection
Source sentences
Summary
Circulating blood levels of cGMP, nitrites, cAMP, and VIP (P < 0.005) increased with development of shock.
2 context sentences(design, population, supporting numbers)
Summary · context
Cyclic nucleotides and VIP were evaluated during Escherichia coli septicemia in two groups of rabbits; 1) sepsis alone and 2) sepsis and a competitive inhibitor of nitric oxide synthase, NG-monomethyl-L-arginine.
Summary · context
Arterial blood was obtained for determination of bacteremia, lactic acidemia, nucleotides, nitrites, and VIP levels.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0753744701
04AnimalEndogenous levelAnimal study (in vivo)Other
In rabbits with E. coli septicemia, animals treated with NG-monomethyl-L-arginine produced less VIP than animals with sepsis alone.
In plain wordsIn rabbits with severe infection, an inhibitor of nitric oxide production lowered the rise in the body's own VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP production with nitric oxide synthase inhibitor
Study
rabbitn: not reported in source
Escherichia coli septicemia
Comparator
Sepsis alone
Outcome group
Endogenous peptide levels · Infection
Source sentences
Summary
The NG-monomethyl-L-arginine treated animals had less cGMP, nitrites, cAMP, and VIP produced (P < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Cyclic nucleotides and VIP were evaluated during Escherichia coli septicemia in two groups of rabbits; 1) sepsis alone and 2) sepsis and a competitive inhibitor of nitric oxide synthase, NG-monomethyl-L-arginine.
Summary · context
Arterial blood was obtained for determination of bacteremia, lactic acidemia, nucleotides, nitrites, and VIP levels.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0753744702

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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