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Study · In vitro (cells) · mouse · 1994

3 results

Vasoactive intestinal polypeptide stimulates cyclic AMP production in mouse N1E-115 neuroblastoma cells: modulation by a protein kinase C activator and ionomycin.

Inukai T, Chik CL, Ho AK

Peptides1 Jan 1994Cited by 4 (Europe PMC)

PMID7535423 (opens in a new tab)DOI10.1016/0196-9781(94)90109-0 (opens in a new tab)PepBankPUB-07535423
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In mouse N1E-115 neuroblastoma cells, VIP treatment caused a 55-fold increase in cAMP accumulation.

    In plain wordsIn mouse nerve-tumour cells grown in the lab, VIP raised cAMP, an internal signal molecule, 55-fold.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreasecAMP accumulation
    Study

    mousen: not reported in source

    N1E-115 neuroblastoma cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    cAMP accumulation
    55 fold
    VIP-treated N1E-115 cells

    Source sentences

    Summary
    VIP treatment caused a 55-fold increase in cAMP accumulation.
    1 context sentence
    Summary · context
    In this study, we investigated the vasoactive intestinal polypeptide (VIP)-stimulated cAMP production and its interaction with protein kinase C activation and elevation of intracellular Ca2+ in N1E-115 neuroblastoma cells.

Studies that did not test the peptide alone2

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  1. 02LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Mechanism

    In mouse N1E-115 cells, 4 beta-phorbol 12-myristate 13-acetate, a protein kinase C activator, reduced the VIP-stimulated cAMP response.

    In plain wordsIn mouse nerve-tumour cells, a chemical that switches on protein kinase C lowered the cAMP response to VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseEffect of phorbol ester (PMA) on VIP-stimulated cAMP
    Study

    mousen: not reported in source

    N1E-115 neuroblastoma cells
    Comparator
    No PMA
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Addition of 4 beta-phorbol 12-myristate 13-acetate reduced VIP- but not forskolin-stimulated cAMP response.
    1 context sentence
    Summary · context
    In this study, we investigated the vasoactive intestinal polypeptide (VIP)-stimulated cAMP production and its interaction with protein kinase C activation and elevation of intracellular Ca2+ in N1E-115 neuroblastoma cells.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  2. 03LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Mechanism

    In mouse N1E-115 cells, ionomycin potentiated the VIP-induced cAMP accumulation.

    In plain wordsIn mouse nerve-tumour cells, ionomycin made the cAMP response to VIP stronger.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseEffect of ionomycin on VIP-stimulated cAMP
    Study

    mousen: not reported in source

    N1E-115 neuroblastoma cells
    Comparator
    No ionomycin
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    ionomycin potentiated both VIP- and forskolin-induced cAMP accumulation.
    1 context sentence
    Summary · context
    In this study, we investigated the vasoactive intestinal polypeptide (VIP)-stimulated cAMP production and its interaction with protein kinase C activation and elevation of intracellular Ca2+ in N1E-115 neuroblastoma cells.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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